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RECRUITING Not applicable ClinicalTrials.gov

Platelet Rich Plasma for Uterine Scar

Sponsor: The University of Texas Health Science Center, Houston • ClinicalTrials.gov ID: NCT05224726

Registry updated: 2026-09-30
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Description

When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing. Platelet-rich plasma (PRP), a modification of fibrin glue made from autologous blood, is being used to deliver growth factors in high concentration to sites requiring wound healing. PRP is obtained from a sample of patients' blood drawn at the time of treatment. As the rate of cesarean deliveries has been rising, long-term adverse sequelae due to uterine scar defects have been increasing. PRP might be a simple preventive treatment that potentially can reduce morbidity following cesarean deliveries.

Interventions

  • Platelet Rich Plasma (Other)
    Injection of 5cc of PRP preparation at the myometrium around the uterine incision after it has been sutured.
  • Placebo (Other)
    Injection of 5cc of 0.9% Normal Saline at the myometrium around the uterine incision after it has been sutured.

Eligibility criteria

Inclusion criteria: * Women undergoing elective cesarean delivery * Term pregnancy (≥37 weeks of gestation) Exclusion criteria: * Thrombocytopenia (CBC Platelet count \<70,000) * Connective tissue disease * Uterine scars other than cesarean (s/p myomectomy, s/p cornual resection) * Malformed uterus (unicornuate, bicornuate, didelphic)

Conditions

Cesarean Section Complications Uterine Bleeding Pelvic Pain Menstrual Irregularity

Locations

  • Sheba Medical Center — Ramat Gan, Center, Israel
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record