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Assessing the Potential Role of the Gut Microbiome in Modulating Physical Abilities in Humans

Sponsor: Assaf-Harofeh Medical Center • ClinicalTrials.gov ID: NCT05024188

Registry updated: 2026-10-13

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Description

The intestinal microbiome is a microbial system that is influenced by host genetics and environmental exposures such as nutrition, stress and medications. There is a growing body of evidence indicating the significant contribution of the gut microbiome to host health and disease. Furthermore, it has been shown that exercise may modify the microbiome composition. However, important mechanistic questions related to the possible associations between exercise and the human gut microbiome remain unanswered. In this study, the investigators are using advanced state-of-the-art measurements of physical activity level and related metabolic parameters whether there is a connection between the microbiome and physical abilities in healthy participants and whether antibiotics consumption can influence host physical abilities and glycemic responses through changes induced in microbiome composition and function.

Interventions

Antibiotics (Drug)
Ciprofloxacin, 500 mg 2/day \& Metronidazole (Flagyl), 500 mg 3/day.
Autologous Fecal Microbiota Transplantation (Other)
Autologous Fecal Microbiota Transplantation( aFMT( stool taken from the participant, prior to antibiotic treatment)
Cellules Pills (Other)
7 days of cellules placebo pills.
placebo capsules (Other)
Placebo capsules consist of saline/glycerol (the same vehicle as in a FMT capsules)

Eligibility criteria

Inclusion Criteria: * Age - 20-55 * Are used to exercise in aerobic sports (running, swimming, 'zumba', ball games, functional training, surfing, tennis, wrestling ext.). * Exercise at least twice a week, for a minimum duration of the last 6 months. Exclusion Criteria: * Consumption of antibiotics (PO) or probiotics 3 months prior to the first day of the experiment. * Diagnosis of type 1 or type 2 diabetes. * Pregnancy, fertility treatments, breastfeeding women six months prior to enrollment and during the study. * Chronic disease-under the discretion of the study medical team (e.g. AIDS, Cushing syndrome, Chronic kidney disease (CKD), acromegaly, hyperthyroidism etc.) * Cancer and recent anticancer treatment * Psychiatric disorders * Coagulation disorders * Gastrointestinal disorders * Bariatric surgery * Alcohol or substance abuse * Any physical condition precluding the completion of a routine effort test * Allergy to Flagyl (Metronidazole) and/ or Ciprodex (Ciprofloxacin)

Conditions

Physical Abilities FMT

Locations

Weizmann Institute of Science — Rehovot, Israel

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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