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RECRUITING Not applicable ClinicalTrials.gov

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation

Sponsor: M.D. Anderson Cancer Center • ClinicalTrials.gov ID: NCT05010109

Registry updated: 2026-09-16
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Description

This study assesses cardiovascular injury and cardiac fitness in patients with non-small cell lung cancer that has spread to nearby tissue or lymph nodes (locally advanced) receiving model based personalized chemoradiation. The goal of this study is to learn more about the risk of developing heart disease as a result of chemoradiation treatment for lung cancer. Researchers also want to learn if the risk can be reduced by using a patient's individual risk profile to guide cancer treatment and help protect the heart.

Interventions

  • 6 Minute Walk Functional Test (Procedure)
    Participate in 6 MWT
  • Biospecimen Collection (Procedure)
    Undergo blood and urine sample collection
  • Computed Tomography (Procedure)
    Undergo SPECT/CT
  • Echocardiography (Procedure)
    Undergo echocardiogram
  • Exercise Cardiac Stress Test (Procedure)
    Undergo stress test
  • Questionnaire Administration (Other)
    Complete questionnaires
  • Single Photon Emission Computed Tomography (Procedure)
    Undergo SPECT/CT

Eligibility criteria

Inclusion Criteria: 1. Patient with histologic diagnosis of non-small cell lung cancer, small cell lung cancer, or limited stage - small cell lung cancer (L-SCLC) 2. The recommended treatment is thoracic radiation therapy combined with concurrent systemic therapy (chemotherapy and/or immunotherapy) with or without neoadjuvant and/or adjuvant systemic therapy (chemotherapy, immunotherapy, targeted therapy) 3. \>/= 18 years of age 4. KPS \>/= 70 5. Willing and able to sign informed consents 6. Willing to perform 6minute walking test 7. Willing to preform required cardiac biomarker test for primary end point assessment. Exclusion criteria: 1. Unable or unwilling to give written informed consent 2. Previous history of RT to the thorax overlapping with the current treatment field. 3. Pregnant or breast-feeding 4. Renal failure necessitating dialysis 5. Unwilling to perform protocol tests 6. Contraindication for any protocol tests

Conditions

Locally Advanced Lung Non-Small Cell Carcinoma Stage III Lung Cancer AJCC v8 Stage IIIA Lung Cancer AJCC v8 Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8

Locations

  • M D Anderson Cancer Center — Houston, Texas, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record