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RECRUITING Not applicable ClinicalTrials.gov

Using Nicotine to Reverse Age-related Auditory Processing Deficits

Sponsor: University of California, Irvine • ClinicalTrials.gov ID: NCT04971954

Registry updated: 2026-10-19
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Description

The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.

Interventions

  • Nicotine gum (Other)
    Nicotine (6 mg) will be administered in the form of polacrilex gum that is available as an over-the-counter medication
  • Placebo gum (Other)
    The placebo will also be a commercially available gum that resembles the nicotine gum in flavor, size, shape, color, and texture.

Eligibility criteria

Inclusion Criteria: * between 18 and 85 years of age * non-smokers with a score of 0-2 out of 10 maximum on the Fagerström index of smoking dependency * cognitive performance within two standard deviations of the CERAD mean Exclusion Criteria: * less than 18 or greater than 85 years of age * deafness or excessive hearing loss * smokers with a score between 3 and 10 on the Fagerström index of smoking dependency * history of psychiatric illness, neurological disorders, diabetes mellitus, renal failure, or cardiovascular disease * regular use of prescription medications (excluding oral contraceptives) * drug dependency

Conditions

Auditory Perceptual Impairment Aging

Locations

  • Hearing and Speech Lab — Irvine, California, United States
  • San Diego State University — San Diego, California, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record