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RECRUITING Phase 3 ClinicalTrials.gov

A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Sponsor: AbbVie • ClinicalTrials.gov ID: NCT04928846

Registry updated: 2026-10-19
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Description

Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. Non-small cell lung cancer (NSCLC) is a solid tumor, a disease in which cancer cells form in the tissues of the lung. The purpose of this study is to determine if telisotuzumab vedotin works better than docetaxel and to assess how safe telisotuzumab vedotin is in adult participants with NSCLC who have previously been treated. Change in disease activity and adverse events will be assessed. Telisotuzumab vedotin is an investigational drug being developed for the treatment of NSCLC. Participants will be randomly assigned a treatment of telisotuzumab vedotin or docetaxel at an 1:1 ratio. Each group receives intravenous (IV) infusion of telisotuzumab vedotin or IV infusion of docetaxel. Approximately 768 adult participants with c-Met overexpressing NSCLC will be enrolled in the study in approximately 330 sites worldwide. Participants will receive IV telisotuzumab vedotin every 2 weeks or docetaxel every 3 weeks until meeting study drug discontinuation criteria. At the conclusion of the study, participants who continue to demonstrate clinical benefit may be eligible to receive study treatment via an extension of the study, a rollover study, or through another mechanism. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

Interventions

  • Telisotuzumab Vedotin (Biological)
    Intravenous (IV) Infusion
  • Docetaxel (Drug)
    IV Infusion

Eligibility criteria

Inclusion Criteria: * Projected life expectancy of at least 12 weeks. * Participants must have c-Met overexpressing non-small cell lung cancer (NSCLC) as assessed by an AbbVie designated immunohistochemistry (IHC) laboratory using the VENTANA MET (SP44) RxDx assay. * Archival or fresh tumor material must be submitted for assessment of c-Met protein expression levels during the Pre-Screening period. Tumor material from the primary tumor site and/or metastatic sites are allowed. * If a participant was prescreened for Study M14-239 but did not enroll, tumor material previously submitted for Study M14-239 may be used for Study M18-868 Pre-Screening upon confirmation from AbbVie that sufficient evaluable tumor material is available (Except China). * A histologically or cytologically documented non-squamous cell NSCLC that is locally advanced or metastatic. * A known epidermal growth factor receptor (EGFR) activating mutation status. \-- Participants with EGFR activating mutations are not eligible * Actionable alterations in genes other than EGFR are eligible. * Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. * An Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1. * Have received no more than 1 line of prior systemic cytotoxic chemotherapy in the locally advanced or metastatic setting. * Have progressed on at least 1 line of prior therapy for locally advanced/metastatic NSCLC * Participants WITHOUT an actionable gene alteration: must have progressed on (or be considered ineligible for) platinum-based chemotherapy and immune checkpoint inhibitor (as monotherapy or in combination with chemotherapy). * Participants WITH an actionable gene alteration for which immune checkpoint inhibitor therapy is not standard of care (e.g., anaplastic lymphoma kinase \[ALK\] translocation): must have progressed on (or be considered ineligible for) anti-cancer therapy targeting driver gene alterations and platinum-based chemotherapy. * Participants with gene alterations for which immune checkpoint inhibitor is standard of care must have also progressed on (or be considered ineligible for) immune checkpoint inhibitor (as monotherapy or in combination with chemotherapy). * Must be considered appropriate for docetaxel therapy based on the assessment of the treating physician. * Participants with metastases to the central nervous system (CNS) are eligible only after adequate treatment (such as surgery, radiotherapy, or drug therapy) is provided and: * They are asymptomatic and off or on a stable or reducing dose of systemic steroids (on no more than 10 mg per day \[QD\] prednisone or equivalent) and/or anticonvulsants for at least 2 weeks prior to randomization. Exclusion Criteria: * Evidence of new, untreated CNS metastases or progressing CNS metastases after treatment. * Evidence of leptomeningeal disease. * Participants with adenosquamous or neuroendocrine histology, nor sarcomatoid features. * Epidermal growth factor receptor (EGFR) activating mutations. * Participants who have received prior c-Met-targeted antibodies, prior telisotuzumab vedotin, or prior antibody-drug conjugates either targeting c-Met or consisting of monomethylauristatin E.. * Participants who have received prior docetaxel therapy. * A history of other malignancies except: * Malignancy treated with curative intent and with no known active disease present for \>=2 years before the first dose of study drug and felt to be at low risk for recurrence by investigator. Additionally, participants must not be receiving any ongoing anti-cancer therapy, including maintenance therapy, prior to randomization.. * Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease. * Adequately treated carcinoma in situ without current evidence of disease. * A history of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, evidence of active pneumonitis on screening chest computed tomography (CT) scan or prior pneumonectomy. A history of prior radiation pneumonitis in the radiation field (fibrosis) is not permitted. * Unresolved nor adverse event (AE) \>= Grade 2 from prior anticancer therapy, except for alopecia or anemia. Participants with hormone deficiencies caused by prior anticancer therapy who are asymptomatic and on a stable dose of replacement hormone are eligible for study. * Major surgery within 21 days prior to randomization. * Clinically significant condition(s) as listed in the protocol.

Conditions

Non Small Cell Lung Cancer c-MET

Locations

  • University of Alabama at Birmingham - Main /ID# 247074 — Birmingham, Alabama, United States
  • Ironwood Cancer & Res Ctr /ID# 262446 — Chandler, Arizona, United States
  • Mayo Clinic Arizona /ID# 255858 — Phoenix, Arizona, United States
  • Onvida Health Yuma Medical Center /ID# 253625 — Yuma, Arizona, United States
  • City of Hope /ID# 243157 — Duarte, California, United States
  • City Of Hope - Seacliff /ID# 263143 — Huntington Beach, California, United States
  • City of Hope - Orange County Lennar Foundation Cancer Center /ID# 263144 — Irvine, California, United States
  • City Of Hope - Antelope Valley /ID# 263138 — Lancaster, California, United States
  • The Oncology Institute Of Hope & Innovation -East Los A /ID# 239774 — Los Angeles, California, United States
  • Eisenhower Medical Center /ID# 233189 — Rancho Mirage, California, United States
  • Premiere Oncology Foundation /ID# 253954 — Santa Monica, California, United States
  • Mayo Clinic Hospital Jacksonville /ID# 254688 — Jacksonville, Florida, United States
  • Ocala Oncology Florida Cancer Affiliates - Main /ID# 234228 — Ocala, Florida, United States
  • BRCR Medical Center Inc /ID# 262344 — Tamarac, Florida, United States
  • Memorial University Medical Center /ID# 264081 — Savannah, Georgia, United States
  • Kaiser Permanente Moanalua Medical Center /ID# 238363 — Honolulu, Hawaii, United States
  • Edward-Elmhurst Cancer Center /ID# 238552 — Elmhurst, Illinois, United States
  • Springfield Clinic - First /ID# 262290 — Springfield, Illinois, United States
  • Goshen Center for Cancer Care /ID# 257734 — Goshen, Indiana, United States
  • Investigative Clinical Research of Indiana - Indianapolis /ID# 260468 — Indianapolis, Indiana, United States
  • Baptist Health Lexington /ID# 252769 — Lexington, Kentucky, United States
  • Dana-Farber Cancer Institute /ID# 247132 — Boston, Massachusetts, United States
  • Trinity Health St. Joseph Mercy Ann Arbor /ID# 232190 — Ypsilanti, Michigan, United States
  • Mayo Clinic - Rochester /ID# 252052 — Rochester, Minnesota, United States
  • Hattiesburg Clinic /ID# 248033 — Hattiesburg, Mississippi, United States
  • St. Luke's Hospital - Chesterfield /ID# 251688 — Chesterfield, Missouri, United States
  • St. Lukes Hosp. of Kansas City /ID# 259940 — Kansas City, Missouri, United States
  • Alliance for Multispecialty Research (AMR) - Kansas City /ID# 247567 — Kansas City, Missouri, United States
  • Hulston Cancer Center /ID# 232226 — Springfield, Missouri, United States
  • Saint Louis University Cancer Center /ID# 260722 — St Louis, Missouri, United States
  • Intermountain Health St Vincent Regional Hospital - Cancer Centers of Montana /ID# 253147 — Billings, Montana, United States
  • Nebraska Hematology Oncology /ID# 257710 — Lincoln, Nebraska, United States
  • Renown Medical Group - Oncology/Hematology /ID# 247942 — Reno, Nevada, United States
  • Astera Cancer Care /ID# 257753 — East Brunswick, New Jersey, United States
  • San Juan Oncology Associates /ID# 244387 — Farmington, New Mexico, United States
  • Maimonides Medical Center /ID# 240783 — Brooklyn, New York, United States
  • Northwell Health - Monter Cancer Center /ID# 247081 — Lake Success, New York, United States
  • AdventHealth Hendersonville /ID# 265349 — Hendersonville, North Carolina, United States
  • FirstHealth of the Carolinas- Speciality Center /ID# 241279 — Pinehurst, North Carolina, United States
  • Genesis Cancer Care Center /ID# 239190 — Zanesville, Ohio, United States
  • Cancer Care Associates Of York /ID# 266143 — York, Pennsylvania, United States
  • Medical University of South Carolina /ID# 251383 — Charleston, South Carolina, United States
  • St Francis Cancer Center /ID# 243596 — Greenville, South Carolina, United States
  • Avera Cancer Institute - Aberdeen /ID# 257759 — Aberdeen, South Dakota, United States
  • Avera Cancer Institute /ID# 239635 — Sioux Falls, South Dakota, United States
  • Duplicate_Memphis VA Medical Center /ID# 263250 — Memphis, Tennessee, United States
  • Dell Seton Medical Center /ID# 247016 — Austin, Texas, United States
  • Community Cancer Trials of Utah - South Ogden /ID# 262829 — Ogden, Utah, United States
  • Valley Medical Center /ID# 253950 — Renton, Washington, United States
  • Medical Oncology Associates /ID# 247003 — Spokane, Washington, United States
  • Cemic /Id# 231486 — Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina
  • Hospital Britanico de Buenos Aires /ID# 231495 — Ciudad Autonoma de Buenos Aire, Buenos Aires, Argentina
  • Centro Médico Austral /ID# 239860 — Ciudad Autonoma Buenos Aires, Buenos Aires F.D., Argentina
  • Centro de Investigaciones Clinicas Clinica Viedma S.A. /ID# 232339 — Viedma, Río Negro Province, Argentina
  • LC Investigacion /ID# 239880 — Buenos Aires, Argentina
  • Instituto de Oncologia Angel H Roffo /ID# 231499 — Buenos Aires, Argentina
  • Port Macquarie Base Hospital /ID# 273654 — Port Macquarie, New South Wales, Australia
  • Westmead Hospital /ID# 274447 — Westmead, New South Wales, Australia
  • Barwon Health /ID# 241920 — Geelong, Victoria, Australia
  • Austin Health /ID# 247507 — Heidelberg, Victoria, Australia
  • Medizinische Universitaet Wien /ID# 230615 — Vienna, State of Vienna, Austria
  • Klinik Penzing /ID# 230700 — Vienna, State of Vienna, Austria
  • Klinik Floridsdorf /ID# 230608 — Vienna, State of Vienna, Austria
  • Medizinische Universitaet Innsbruck /ID# 240981 — Innsbruck, Tyrol, Austria
  • Ordensklinikum Linz Elisabethinen /ID# 240967 — Linz, Upper Austria, Austria
  • Klinikum Wels-Grieskirchen Gmbh /ID# 249000 — Wels, Upper Austria, Austria
  • Landeskrankenhaus Feldkirch /ID# 250333 — Feldkirch, Vorarlberg, Austria
  • Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 232467 — Salzburg, Austria
  • Algemeen Ziekenhuis klina /ID# 239853 — Brasschaat, Antwerpen, Belgium
  • Universitair Ziekenhuis Antwerpen /ID# 239971 — Edegem, Antwerpen, Belgium
  • Grand Hopital de Charleroi - Les Viviers /ID# 234178 — Charleroi, Hainaut, Belgium
  • Hospital La Louviere Site Jolimont - Helora /ID# 246771 — La Louvière, Hainaut, Belgium
  • Jessa Ziekenhuis /ID# 246766 — Hasselt, Limburg, Belgium
  • UZ Gent /ID# 273244 — Ghent, Oost-Vlaanderen, Belgium
  • Vitaz /Id# 246773 — Sint-Niklaas, Oost-Vlaanderen, Belgium
  • Institut Jules Bordet /ID# 246770 — Anderlecht, Belgium
  • AZ Maria Middelares /ID# 246768 — Ghent, Belgium
  • CHU de Liege /ID# 246772 — Liège, Belgium
  • UCL Namur University Hospital, Site Sainte-Elisabeth /ID# 246769 — Namur, Belgium
  • Clinica Amo - Rio Vermelho /ID# 231604 — Salvador, Estado de Bahia, Brazil
  • Hospital Da Crianca Santo Antonio /ID# 233249 — Porto Alegre, Rio Grande do Sul, Brazil
  • Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 233247 — Barretos, São Paulo, Brazil
  • OC Oncoclínicas SP /ID# 261828 — São Paulo, São Paulo, Brazil
  • Instituto Nacional de Cancer (INCA) /ID# 231509 — Rio de Janeiro, Brazil
  • Instituto Dor de Pesquisa e Ensino /ID# 233245 — Rio de Janeiro, Brazil
  • Instituto de Ensino e Pesquisas Sao Lucas /ID# 247417 — São Paulo, Brazil
  • Hospital Sirio Libanes - Sao Paulo /ID# 261827 — São Paulo, Brazil
  • Casa de Saúde Santa Marcelina /ID# 231605 — São Paulo, Brazil
  • Uni Hospital /ID# 273707 — Panagyurishte, Pazardzhik, Bulgaria
  • University Multiprofile Hospital for Active Treatment Sofiamed /ID# 234108 — Sofiya, Sofia, Bulgaria
  • Complex Oncology Center - Burgas /ID# 240532 — Burgas, Bulgaria
  • Complex Cancer Center Plovdiv /ID# 234106 — Plovdiv, Bulgaria
  • UMHAT Multiprofile Hospital for Active Treatment Sveta Marina /ID# 234112 — Varna, Bulgaria
  • Cross Cancer Institute. /ID# 252065 — Edmonton, Alberta, Canada
  • William Osler Health System - Brampton Civic Hospital /ID# 254420 — Brampton, Ontario, Canada
  • CISSS de la Monteregie /ID# 239081 — Greenfield Park, Quebec, Canada
  • CSSS Alphonse-Desjardins, CHAU de Levis /ID# 261158 — Lévis, Quebec, Canada
  • Hopital Du Sacre-Coeur De Montreal /ID# 274584 — Montreal, Quebec, Canada
  • Clinica Universidad Catolica del Maule /ID# 231294 — Talca, Maule Region, Chile
  • Icegclinic /Id# 231212 — La Florida, Santiago Metropolitan, Chile
  • Sociedad Prosalud Montes y Orlandi /ID# 231154 — Providencia, Santiago Metropolitan, Chile
  • Fundacion Arturo Lopez Perez /ID# 231151 — Providencia, Santiago Metropolitan, Chile
  • Sociedad Oncovida /ID# 231152 — Providencia, Santiago Metropolitan, Chile
  • Hospital Clinico Universidad De Los Andes /ID# 260974 — Santiago, Chile
  • Anhui Medical University - Anhui Chest Hospital /ID# 231899 — Hefei, Anhui, China
  • Beijing Cancer Hospital /ID# 231923 — Beijing, Beijing Municipality, China
  • Peking Union Medical College Hospital East - Dongdan Campus /ID# 233175 — Beijing, Beijing Municipality, China
  • Beijing Chest Hospital, Capital Medical University /ID# 232202 — Beijing, Beijing Municipality, China
  • The First Affiliated Hospital of Chongqing Medical University /ID# 251592 — Chongqing, Chongqing Municipality, China
  • Fujian Provincial Cancer Hospital /ID# 243134 — Fuzhou, Fujian, China
  • The First Affiliated Hospital of Xiamen University /ID# 242381 — Xiamen, Fujian, China
  • The First Affiliated Hospital Of Guangzhou Medical University - Yanjiang W Road /ID# 238591 — Guangzhou, Guangdong, China
  • Cancer Hospital of Shantou University Medical College /ID# 242182 — Shantou, Guangdong, China
  • Affiliated Hospital of Guangdong Medical College /ID# 233317 — Zhanjiang, Guangdong, China
  • Affiliated Cancer Hospital of Guangxi Medical University /ID# 231855 — Nanning, Guangxi, China
  • People's Hospital of Guizhou Province /ID# 243614 — Guiyang, Guizhou, China
  • Affiliated Hospital of Hebei University /ID# 239586 — Baoding, Hebei, China
  • Harbin Medical University Cancer Hospital /Id# 231941 — Harbin, Heilongjiang, China
  • The First affiliated Hospital of Nanyang Medical College /ID# 244652 — Nanyang, Henan, China
  • People's Hospital of Henan Province /ID# 242187 — Zhengzhou, Henan, China
  • Henan Cancer Hospital /ID# 239577 — Zhengzhou, Henan, China
  • Tongji Hospital Tongji Medical College of HUST /ID# 239575 — Wuhan, Hubei, China
  • Union Hospital Tongji Medical College /ID# 231904 — Wuhan, Hubei, China
  • Hubei Cancer Hospital /ID# 240045 — Wuhan, Hubei, China
  • Hunan Cancer Hospital /ID# 231943 — Changsha, Hunan, China
  • The Affiliated Hospital of Inner Mongolia Medical University /ID# 242179 — Hohhot, Inner Mongolia, China
  • Nanjing Drum Tower Hospital /ID# 231791 — Nanjing, Jiangsu, China
  • Nantong Tumor Hospital /ID# 232424 — Nantong, Jiangsu, China
  • The First Affiliated Hospital of Nanchang University /ID# 231934 — Nanchang, Jiangxi, China
  • The Second Affiliated Hospital of Nanchang University /ID# 231935 — Nanchang, Jiangxi, China
  • Jilin Cancer Hospital /ID# 244702 — Changchun, Jilin, China
  • The Second Affiliated Hospital of Dalian Medical University /ID# 239755 — Dalian, Liaoning, China
  • First Affiliated Hospital of China Medical University /ID# 231924 — Shenyang, Liaoning, China
  • The First Affiliated Hospital of Xi'an Jiaotong University /ID# 232023 — Xi'an, Shaanxi, China
  • Jinan Central Hospital /ID# 231895 — Jinan, Shandong, China
  • Shandong Cancer Hospital /ID# 251506 — Jinan, Shandong, China
  • LinYi Cancer Hospital /ID# 239713 — Linyi, Shandong, China
  • Shanghai Chest Hospital /ID# 231897 — Shanghai, Shanghai Municipality, China
  • Shanxi Cancer Hospital /ID# 258674 — Taiyuan, Shanxi, China
  • Sichuan Cancer Hospital /ID# 239707 — Chengdu, Sichuan, China
  • West China Hospital, Sichuan University /ID# 233703 — Chengdu, Sichuan, China
  • Tianjin Cancer Hospital /ID# 233176 — Tianjin, Tianjin Municipality, China
  • Tianjin Medical University General Hospital /ID# 231839 — Tianjin, Tianjin Municipality, China
  • The Affiliated Cancer Hospital of Xinjiang Medical University /ID# 240094 — Ürümqi, Xinjiang, China
  • Yunnan Cancer Hospital /ID# 251388 — Kunming, Yunnan, China
  • The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 232032 — Hangzhou, Zhejiang, China
  • Zhejiang Cancer hospital /ID# 242476 — Hangzhou, Zhejiang, China
  • Taizhou Hospital of Zhejiang Province /ID# 232021 — Linhai, Zhejiang, China
  • Ningbo No. 2 Hospital /ID# 242478 — Ningbo, Zhejiang, China
  • Hospital Pablo Tobon Uribe /ID# 258128 — Medellín, Antioquia, Colombia
  • Fundacion Ctic - Centro De Tratamiento E Investigacion Sobre Cancer Luis Carlos /ID# 258131 — Bogotá, Bogota D.C., Colombia
  • Sociedad de Oncologia y Hematologia del Cesar SAS /ID# 258130 — Valledupar, Cesar Department, Colombia
  • Imat Oncomedica /ID# 258129 — Montería, Departamento de Córdoba, Colombia
  • Masarykuv onkologicky ustav /ID# 232426 — Brno, Czechia
  • Nemocnice AGEL Novy Jicin, a.s. /ID# 232427 — Nový Jičín, Czechia
  • Zealand University Hospital /ID# 241842 — Køge, Region Sjælland, Denmark
  • Odense University Hospital /ID# 241663 — Odense, Region Syddanmark, Denmark
  • APHM - Hopital Nord /ID# 251935 — Marseille, Bouches-du-Rhone, France
  • Centre Hospitalier Regional Universitaire de Lille - Hopital Albert Calmette /ID# 251934 — Lille, Hauts-de-France, France
  • Hopital Arnaud de Villeneuve /ID# 239404 — Montpellier, Herault, France
  • Centre Hospitalier Universitaire de Bordeaux /ID# 244953 — Pessac, New Aquitaine, France
  • Institut Curie /ID# 240141 — Paris, Paris, France
  • Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 239409 — Paris, Paris, France
  • Centre Hospitalier d'Avignon /ID# 275229 — Avignon, Provence-Alpes-Côte d'Azur Region, France
  • Hospices Civils de Lyon - Hopital Louis Pradel /ID# 251933 — Bron, Rhone, France
  • Centre Leon Berard /ID# 267397 — Lyon, Rhone, France
  • Centre Hosp Intercommunal de Creteil /ID# 251936 — Créteil, Val-de-Marne, France
  • AP-HP - Hopital Tenon /ID# 239179 — Paris, France
  • Institut Gustave Roussy /ID# 267415 — Villejuif, Île-de-France Region, France
  • Thoraxklinik Heidelberg gGmbH /ID# 239656 — Heidelberg, Baden-Wurttemberg, Germany
  • Universitatsklinikum Mannheim /ID# 238331 — Mannheim, Baden-Wurttemberg, Germany
  • Asklepios Fachkliniken Muenchen-Gauting /ID# 272768 — Gauting, Bavaria, Germany
  • Universitaetsklinikum Giessen /ID# 252973 — Giessen, Hesse, Germany
  • Klinikum Kassel /ID# 240142 — Kassel, Hesse, Germany
  • Universitaetsklinikum Carl Gustav Carus Dresden /ID# 274719 — Dresden, Saxony, Germany
  • Zentralklinik Bad Berka /ID# 239661 — Bad Berka, Thuringia, Germany
  • Charite Universitaetsmedizin Berlin Campus Virchow-Klinikum /ID# 234247 — Berlin, Germany
  • Universitaetsklinikum Hamburg-Eppendorf /ID# 239658 — Hamburg, Germany
  • Haemato-Onkologie Hamburg /ID# 241047 — Hamburg, Germany
  • Henry Dunnant Hospital Center /ID# 267021 — Athens, Attica, Greece
  • Thoracic General Hospital of Athens I Sotiria /ID# 230824 — Athens, Attica, Greece
  • Metropolitan Hospital /ID# 232158 — Piraeus, Attica, Greece
  • Metropolitan Hospital /ID# 239170 — Piraeus, Attica, Greece
  • Interbalkan Medical Center Of Thessaloniki /ID# 254407 — Thessaloniki, Greece
  • ZIV Medical Center /ID# 238606 — Safed, Northern District, Israel
  • Soroka University Medical Center /ID# 252711 — Beersheba, Southern District, Israel
  • The Edith Wolfson Medical Center /ID# 233781 — Holon, Southern District, Israel
  • Tel Aviv Sourasky Medical Center /ID# 260519 — Tel Aviv, Tel Aviv, Israel
  • Humanitas Istituto Clinico Catanese /ID# 273050 — Misterbianco, Catania, Italy
  • IRCCS Ospedale San Raffaele /ID# 254376 — Milan, Milano, Italy
  • Azienda Ospedaliera Universitaria Luigi Vanvitelli - Miraglia /ID# 252942 — Naples, Napoli, Italy
  • Azienda Ospedaliera Complesso Ospedaliero San Giovanni-Addolorata /ID# 238618 — Rome, Roma, Italy
  • I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 238696 — Bari, Italy
  • Azienda Socio Sanitaria Territoriale di Cremona /ID# 238698 — Cremona, Italy
  • Azienda Ospedaliera Papardo /ID# 258038 — Messina, Italy
  • Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia /ID# 238473 — Perugia, Italy
  • ASST Sette Laghi - Ospedale Di Circolo E Fondazione Macchi Varese /ID# 238536 — Varese, Italy
  • NHO Nagoya Medical Center /ID# 246306 — Nagoya, Aichi-ken, Japan
  • Nagoya University Hospital /ID# 239990 — Nagoya, Aichi-ken, Japan
  • Hirosaki University Hospital /ID# 242377 — Hirosaki-shi, Aomori, Japan
  • National Cancer Center Hospital East /ID# 233775 — Kashiwa-shi, Chiba, Japan
  • National Hospital Organization Kyushu Medical Center /ID# 238533 — Fukuoka, Fukuoka, Japan
  • Hospital Of The University Of Occupational And Environmental Health, Japan /ID# 241191 — Kitakyushu-shi, Fukuoka, Japan
  • Kurume University Hospital /ID# 254900 — Kurume-shi, Fukuoka, Japan
  • Gunma Prefectural Cancer Center /ID# 233723 — Ota-shi, Gunma, Japan
  • Chugoku Central Hospital /ID# 242970 — Fukuyama, Hiroshima, Japan
  • Hiroshima University Hospital /ID# 241882 — Hiroshima, Hiroshima, Japan
  • Hokkaido University Hospital /ID# 241289 — Sapporo, Hokkaido, Japan
  • Kobe Minimally Invasive Cancer Center /ID# 254131 — Kobe, Hyōgo, Japan
  • Takarazuka City Hospital /ID# 240786 — Takarazuka-shi, Hyōgo, Japan
  • NHO Mito Medical Center /ID# 241709 — Higashiibaraki-gun, Ibaraki, Japan
  • Ibaraki Prefectural Central Hospital /ID# 246145 — Kasama-shi, Ibaraki, Japan
  • Iwate Medical University Hospital /ID# 239027 — Shiwa-gun, Iwate, Japan
  • Kitasato University Hospital /ID# 239958 — Sagamihara-shi, Kanagawa, Japan
  • Yokohama City University Medical Center /ID# 246554 — Yokohama, Kanagawa, Japan
  • Kanagawa Cardiovascular and Respiratory Center /ID# 239052 — Yokohama, Kanagawa, Japan
  • Kumamoto University Hospital /ID# 241039 — Kumamoto, Kumamoto, Japan
  • National Hospital Organization Mie Chuo Medical Center /ID# 246659 — Tsu, Mie-ken, Japan
  • Miyagi Cancer Center /ID# 234198 — Natori-shi, Miyagi, Japan
  • Sendai Kousei Hospital /ID# 253350 — Sendai, Miyagi, Japan
  • University of Miyazaki Hospital /ID# 242161 — Miyazaki, Miyazaki, Japan
  • Nagaoka Red Cross Hospital /ID# 240714 — Nagaoka-shi, Niigata, Japan
  • Kurashiki Central Hospital /ID# 239344 — Kurashiki-shi, Okayama-ken, Japan
  • Osaka Habikino Medical Center /ID# 239989 — Habikino-shi, Osaka, Japan
  • Kansai Medical University Hospital /ID# 233476 — Hirakata-shi, Osaka, Japan
  • Osaka Metropolitan University Hospital /ID# 238895 — Osaka, Osaka, Japan
  • Kindai University Hospital /ID# 239085 — Sakai-shi, Osaka, Japan
  • Fujieda Municipal General Hospital /ID# 255155 — Fujieda-shi, Shizuoka, Japan
  • Tochigi Cancer Center /ID# 240020 — Utsunomiya, Tochigi, Japan
  • Juntendo University Hospital /ID# 239932 — Bunkyo-ku, Tokyo, Japan
  • National Cancer Center Hospital /ID# 251134 — Chuo-ku, Tokyo, Japan
  • National Hospital Organization Tokyo Medical Center /ID# 246581 — Meguro-ku, Tokyo, Japan
  • NTT Medical Center Tokyo /ID# 241067 — Shinagawa-ku, Tokyo, Japan
  • Keio University Hospital /ID# 239506 — Shinjuku-ku, Tokyo, Japan
  • Toyama University Hospital /ID# 241660 — Toyama, Toyama, Japan
  • Wakayama Medical University Hospital /ID# 234004 — Wakayama, Wakayama, Japan
  • Yamagata University Hospital /ID# 240815 — Yamagata, Yamagata, Japan
  • Yamaguchi - Ube Medical Center /ID# 258779 — Ube-shi, Yamaguchi, Japan
  • Fukushima Medical University Hospital /ID# 249691 — Fukushima, Japan
  • O.P.D. Hospital Civil de Guadalajara /ID# 238488 — Guadalajara, Jalisco, Mexico
  • Centro de Investigacion Clínica Chapultepec SA de CV /ID# 231928 — Morelia, Michoacán, Mexico
  • Clinical Research & Oncology Oaxaca /ID# 231883 — Oaxaca City, Mexico
  • Ziekenhuis St. Jansdal /ID# 251932 — Harderwijk, Gelderland, Netherlands
  • Maastricht Universitair Medisch Centrum /ID# 233932 — Maastricht, Limburg, Netherlands
  • Isala /ID# 238846 — Zwolle, Overijssel, Netherlands
  • HagaZiekenhuis /ID# 243693 — The Hague, South Holland, Netherlands
  • Jeroen Bosch Ziekenhuis /ID# 234087 — 's-Hertogenbosch, Netherlands
  • Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeyla /ID# 262489 — Poznan, Greater Poland Voivodeship, Poland
  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 262095 — Warsaw, Masovian Voivodeship, Poland
  • MRUK-MED I Sp. z o.o. /ID# 239363 — Rzeszów, Podkarpackie Voivodeship, Poland
  • Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie /ID# 239025 — Olsztyn, Warmian-Masurian Voivodeship, Poland
  • Instytut Centrum Zdrowia Matki Polki /ID# 239024 — Lodz, Łódź Voivodeship, Poland
  • Fundacao Champalimaud /ID# 241925 — Lisbon, Lisbon District, Portugal
  • Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 241572 — Porto, Portugal
  • Hospital CUF Porto /ID# 241570 — Porto, Portugal
  • IPO Porto FG, EPE /ID# 241569 — Porto, Portugal
  • Unidade Local de Saude Sao Joao /ID# 241930 — Porto, Portugal
  • Spitalul Pelican /ID# 254066 — Oradea, Bihor County, Romania
  • Cardiomed Srl /Id# 255320 — Cluj-Napoca, Cluj, Romania
  • Sc Oncolab Srl /Id# 239105 — Craiova, Dolj, Romania
  • SC RTC Radiology Therapeutic Center SRL /ID# 240744 — Otopeni, Ilfov, Romania
  • Oncocenter - Oncologie Clinica Srl /Id# 239103 — Timișoara, Timiș County, Romania
  • Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL /ID# 240826 — Brasov, Romania
  • Institutul Regional de Oncologie /ID# 254065 — Iași, Romania
  • S.C. Sigmedical Services SRL /ID# 239108 — Suceava, Romania
  • Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 230084 — Banská Bystrica, Banská Bystrica Region, Slovakia
  • Wits Clinical Research /ID# 230841 — Johannesburg, Gauteng, South Africa
  • Sandton Oncology Medical Group PTY Ltd /ID# 230843 — Johannesburg, Gauteng, South Africa
  • Steve Biko Academic Hospital /ID# 230883 — Pretoria, Gauteng, South Africa
  • National Cancer Center /ID# 260663 — Goyang-si, Gyeonggido, South Korea
  • CHA Bundang Medical Center /ID# 233318 — Seongnam, Gyeonggido, South Korea
  • The Catholic University Of Korea St. Vincent's Hospital /ID# 256942 — Suwon, Gyeonggido, South Korea
  • Ajou University Hospital - Suwon-si /ID# 233319 — Suwon, Gyeonggido, South Korea
  • Gyeongsang National University Hospital /ID# 234244 — Jinju, Gyeongsangnam-do, South Korea
  • Pusan National University Yangsan Hospital /ID# 257836 — Yangsan, Gyeongsangnam-do, South Korea
  • Chungbuk National University Hospital /ID# 257891 — Cheongju-si, North Chungcheong, South Korea
  • Kangbuk Samsung Hospital /ID# 233711 — Seoul, Seoul Teugbyeolsi, South Korea
  • Samsung Medical Center /ID# 256941 — Seoul, Seoul Teugbyeolsi, South Korea
  • SMG-SNU Boramae Medical Center /ID# 233710 — Seoul, Seoul Teugbyeolsi, South Korea
  • CHU Insular-Materno Infantil /ID# 255094 — Las Palmas de Gran Canaria, Las Palmas, Spain
  • Hospital Universitario Fundacion Alcorcon /ID# 255100 — Alcorcón, Madrid, Spain
  • Hospital Universitario de Fuenlabrada /ID# 255093 — Fuenlabrada, Madrid, Spain
  • Hospital Nuestra Senora de Sonsoles /ID# 255102 — Ávila, Spain
  • UOMi Cancer Center - Clinica Tres Torres /ID# 240584 — Barcelona, Spain
  • Hospital Universitario Dexeus - Grupo Quironsalud /ID# 255105 — Barcelona, Spain
  • Hospital Universitario de Jaen /ID# 240588 — Jaén, Spain
  • Hospital Universitario 12 de Octubre /ID# 240176 — Madrid, Spain
  • Hospital Clinico Universitario de Valencia /ID# 240378 — Valencia, Spain
  • Karolinska University Hospital Solna /ID# 229853 — Solna, Stockholm County, Sweden
  • Sahlgrenska Universitetssjukhuset /ID# 229943 — Gothenburg, Västra Götaland County, Sweden
  • E-DA Cancer Hospital /ID# 239718 — Kaohsiung City, Kaohsiung, Taiwan
  • Changhua Christian Hospital /ID# 238394 — Changhua City, Changhua County, Taiwan
  • National Taiwan University Hospital - Hsinchu branch /ID# 238393 — Hsinchu, Taiwan
  • Hualien Tzu Chi Hospital /ID# 238398 — Hualien City, Taiwan
  • Chung Shan Medical University Hospital /ID# 238444 — Taichung, Taiwan
  • National Taiwan University Hospital /ID# 238378 — Taipei, Taiwan
  • Mackay Memorial Hospital /ID# 238392 — Taipei, Taiwan
  • Taipei Medical University Hospital /ID# 238380 — Taipei, Taiwan
  • Memorial Ankara Hastanesi /ID# 234212 — Çankaya, Ankara, Turkey (Türkiye)
  • Izmir Ekonomi Universitesi Ozel Medicalpoint Hastanesi /ID# 234209 — Cordaleo, İzmir, Turkey (Türkiye)
  • Adana Sehir Egitim ve Arastirma Hastanesi /ID# 255638 — Adana, Turkey (Türkiye)
  • Adana Acıbadem Hospital /ID# 234208 — Adana, Turkey (Türkiye)
  • Medical Park Seyhan Hastanesi /ID# 255637 — Adana, Turkey (Türkiye)
  • Gazi Universitesi /ID# 265425 — Ankara, Turkey (Türkiye)
  • Ankara City Hospital /ID# 234210 — Ankara, Turkey (Türkiye)
  • Inonu Universitesi Turgut Ozal /ID# 234038 — Battalgazi/malatya, Turkey (Türkiye)
  • Uludag University Medical Faculty /ID# 234205 — Bursa, Turkey (Türkiye)
  • Dicle Universitesi Tip /ID# 234036 — Diyarbakır, Turkey (Türkiye)
  • Bagcilar Medipol Mega Universite Hastanesi /ID# 234211 — Istanbul, Turkey (Türkiye)
  • Ege University Medical Faculty /ID# 234039 — Izmir, Turkey (Türkiye)
  • Dr. Suat Seren Gogus Has /ID# 262291 — Izmir, Turkey (Türkiye)
  • St Bartholomews Hospital - Barts Health /ID# 254342 — London, Greater London, United Kingdom
  • UCLH NHS FT - University College Hospital /ID# 249407 — London, Greater London, United Kingdom
  • Nottingham City Hospital /ID# 254707 — Nottingham, Nottinghamshire, United Kingdom
  • Heartlands Hospital - University Hospitals Birmingham /ID# 258141 — Birmingham, West Midlands, United Kingdom
  • The Royal Marsden NHS Foundation Trust /ID# 246974 — London, United Kingdom
  • The Christie Hospital /ID# 243422 — Manchester, United Kingdom
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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