RECRUITING Early Phase 1 ClinicalTrials.gov

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Sponsor: University of Texas Southwestern Medical Center • ClinicalTrials.gov ID: NCT04838678

Registry updated: 2026-09-03

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Description

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

Interventions

Neuropeptide Y (Drug)
intra-arterial infusion of neuropeptide Y

Eligibility criteria

Inclusion Criteria: * Control - BMI\<30, age 18-55 * Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Exclusion Criteria: All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,

Conditions

Hypertension Obesity

Locations

University of Texas Southwestern Medical Center — Dallas, Texas, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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