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RECRUITING Phase 2 ClinicalTrials.gov

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

Sponsor: SWOG Cancer Research Network • ClinicalTrials.gov ID: NCT04511013

Registry updated: 2026-09-15
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Description

This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (brain metastases). Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Ipilimumab and nivolumab are monoclonal antibodies that may interfere with the ability of tumor cells to grow and spread. This trial aims to find out which approach is more effective in shrinking and controlling brain metastases from melanoma.

Interventions

  • Binimetinib (Drug)
    Given PO
  • Encorafenib (Drug)
    Given PO
  • Ipilimumab (Biological)
    Given IV
  • Nivolumab (Biological)
    Given IV

Eligibility criteria

Inclusion Criteria: * Participants must have histologically and pathologically confirmed melanoma that has metastasized to the brain * Any primary (cutaneous, acral/mucosal, etc) or unknown origin are permitted, except that participants with uveal primary are not eligible * Participants must have BRAF-V600 mutant melanoma documented by a Clinical Laboratory Improvement Act (CLIA)-certified laboratory * All participants must have an magnetic resonance imaging (MRI) of the brain within 28 days prior to registration and must have central nervous system metastases with at least one measurable brain metastasis \>= 0.5 cm in size (per modified RECIST 1.1) that has not been irradiated, or progressed (in the opinion of the treating physician) after prior radiation therapy. Participating sites MUST use MRI slice thickness of =\< 1.5 mm and are recommended to adhere to the 'minimum' Brain Tumor Imaging Protocol for Clinical Trials in Brain Metastases (BTIP-BM) compliant MRI acquisition protocol. Computed tomography (CT) of the head cannot substitute for brain MRI. (NOTE: All central nervous system \[CNS\] disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form \[RECIST 1.1\] using RECIST 1.1.) * Participants may have measurable or non-measurable extracranial disease. All measurable disease must be assessed within 28 days prior to randomization; all non-measurable disease must be assessed within 42 days prior to randomization. Please note, while any extracranial disease will also be assessed and followed, participants are NOT required to have extracranial disease for randomization. NOTE: All disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1). CNS disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form (RECIST 1.1) using RECIST 1.1 * Participants may have leptomeningeal disease * Participants may be receiving corticosteroids for brain metastases at a dose of up to 8 mg of dexamethasone per day. The dose must not have exceeded 8 mg per day for at least 7 days prior to randomization * Participants must have Zubrod performance status =\< 2 * Participants must have complete history and physical examination within 28 days prior to randomization * Participants must be able to swallow and retain pills * Hemoglobin \>= 8.0 g/dL (within 28 days prior to randomization) * Absolute neutrophil count \>= 1,500/mcL (within 28 days prior to randomization) * Platelets \>= 75,000/mcL (within 28 days prior to randomization) * Total bilirubin =\< 1.5 institutional upper limit of normal (ULN) (within 28 days prior to randomization) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x institutional ULN (in participants with liver metastases =\< 5 x ULN) (within 28 days prior to randomization) * Creatinine =\< 2.0 institutional ULN (within 28 days prior to randomization) * Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants must be class 2B or better * Participants with a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Participants with known human immunodeficiency virus (HIV)-infection are eligible providing they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 90 days prior to randomization * Participants with a known history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with HCV infection who are currently on treatment must have an undetectable HCV viral load prior to randomization * Participants must agree to participate in image banking. Images must be submitted via the Triad System * Participants must be offered the opportunity to participate in specimen and blood collections * Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines * As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system Exclusion Criteria: * Participants must not have received prior systemic therapy for metastatic disease. Prior systemic therapy received only in the neoadjuvant and/or adjuvant setting (e.g., BRAF/MEK inhibitor therapy, anti-PD-1 therapy or anti-CTLA4 therapy, alfa-interferon, etc.) is permitted. If patients received prior neoadjuvant/adjuvant therapy, they must have had eventual disease relapse prior to randomization * Participants must not have had prior radiation therapy within 7 days prior to randomization * Participants must not be planning to require any additional form of systemic anti-tumor therapy for melanoma while on protocol treatment * Participants must not be planning to use hormonal contraceptives * Participants must not have a serious active infection requiring systemic therapy at time of randomization in the opinion of the treating physician * Participants must not have active autoimmune disease that has required treatment in the past 6 months with use of biologic disease modifying agents (.e.g. infliximab, adalimumab). Patients on non-biologic disease modifying agents (e.g. methotrexate) or patients on corticosteroids =\< 10 mg prednisone daily or equivalent (to treat auto-immune disease), or on replacement therapy (e.g., thyroxine, insulin) are eligible if deemed in the best interest of the patient by treating physician * Participants must not have had grade 3 or 4 immune-related adverse events on ipilimumab or nivolumab that required more than 12 weeks of immune suppression with corticosteroids * Participants must not have had adverse events related to encorafenib and/or binimetinib specifically, that required discontinuation of one or both drugs. (Please note this does not apply to other BRAF/MEK inhibitor drugs.) * Participants must not be pregnant or nursing. Women/men of reproductive potential must have agreed to use an effective method of contraception. (NOTE: Patients must agree to not use hormonal contraceptives, as encorafenib can result in decreased concentration and loss of efficacy.) A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

Conditions

Acral Lentiginous Melanoma Clinical Stage IV Cutaneous Melanoma AJCC v8 Metastatic Cutaneous Melanoma Metastatic Malignant Neoplasm in the Brain Metastatic Melanoma Metastatic Mucosal Melanoma Pathologic Stage IV Cutaneous Melanoma AJCC v8

Locations

  • University of Alabama at Birmingham Cancer Center — Birmingham, Alabama, United States
  • Thomas Hospital — Fairhope, Alabama, United States
  • Mobile Infirmary Medical Center — Mobile, Alabama, United States
  • Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
  • Anchorage Radiation Therapy Center — Anchorage, Alaska, United States
  • Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
  • Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
  • Alaska Women's Cancer Care — Anchorage, Alaska, United States
  • Anchorage Oncology Centre — Anchorage, Alaska, United States
  • Katmai Oncology Group — Anchorage, Alaska, United States
  • Providence Alaska Medical Center — Anchorage, Alaska, United States
  • Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
  • Mercy Hospital Fort Smith — Fort Smith, Arkansas, United States
  • Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
  • Epic Care-Dublin — Dublin, California, United States
  • Bay Area Breast Surgeons Inc — Emeryville, California, United States
  • Epic Care Partners in Cancer Care — Emeryville, California, United States
  • UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California, United States
  • Contra Costa Regional Medical Center — Martinez, California, United States
  • Providence Queen of The Valley — Napa, California, United States
  • Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
  • Bay Area Tumor Institute — Oakland, California, United States
  • Sharp Memorial Hospital — San Diego, California, United States
  • Providence Medical Foundation - Santa Rosa — Santa Rosa, California, United States
  • Providence Santa Rosa Memorial Hospital — Santa Rosa, California, United States
  • Epic Care Cyberknife Center — Walnut Creek, California, United States
  • Rocky Mountain Cancer Centers-Aurora — Aurora, Colorado, United States
  • The Medical Center of Aurora — Aurora, Colorado, United States
  • University of Colorado Hospital — Aurora, Colorado, United States
  • Boulder Community Foothills Hospital — Boulder, Colorado, United States
  • Rocky Mountain Cancer Centers-Boulder — Boulder, Colorado, United States
  • Rocky Mountain Cancer Centers - Centennial — Centennial, Colorado, United States
  • The Women's Imaging Center — Denver, Colorado, United States
  • Colorado Blood Cancer Institute — Denver, Colorado, United States
  • Presbyterian - Saint Lukes Medical Center - Health One — Denver, Colorado, United States
  • Rocky Mountain Cancer Centers-Midtown — Denver, Colorado, United States
  • Rocky Mountain Cancer Centers-Rose — Denver, Colorado, United States
  • Rose Medical Center — Denver, Colorado, United States
  • Western Surgical Care — Denver, Colorado, United States
  • Mountain Blue Cancer Care Center - Swedish — Englewood, Colorado, United States
  • Rocky Mountain Cancer Centers - Swedish — Englewood, Colorado, United States
  • Swedish Medical Center — Englewood, Colorado, United States
  • The Melanoma and Skin Cancer Institute — Englewood, Colorado, United States
  • North Colorado Medical Center — Greeley, Colorado, United States
  • Rocky Mountain Cancer Centers-Lakewood — Lakewood, Colorado, United States
  • Rocky Mountain Cancer Centers-Littleton — Littleton, Colorado, United States
  • Rocky Mountain Cancer Centers-Sky Ridge — Lone Tree, Colorado, United States
  • Sky Ridge Medical Center — Lone Tree, Colorado, United States
  • McKee Medical Center — Loveland, Colorado, United States
  • Rocky Mountain Cancer Centers-Thornton — Thornton, Colorado, United States
  • UM Sylvester Comprehensive Cancer Center at Aventura — Aventura, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Coral Gables — Coral Gables, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach, Florida, United States
  • University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Kendall — Miami, Florida, United States
  • Orlando Health Cancer Institute — Orlando, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Plantation — Plantation, Florida, United States
  • Moffitt Cancer Center-International Plaza — Tampa, Florida, United States
  • Moffitt Cancer Center - McKinley Campus — Tampa, Florida, United States
  • Moffitt Cancer Center — Tampa, Florida, United States
  • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler — Savannah, Georgia, United States
  • Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho, United States
  • Saint Luke's Cancer Institute - Boise — Boise, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
  • Kootenai Health - Coeur d'Alene — Coeur d'Alene, Idaho, United States
  • Walter Knox Memorial Hospital — Emmett, Idaho, United States
  • Saint Luke's Cancer Institute - Fruitland — Fruitland, Idaho, United States
  • Idaho Urologic Institute-Meridian — Meridian, Idaho, United States
  • Saint Luke's Cancer Institute - Meridian — Meridian, Idaho, United States
  • Saint Luke's Cancer Institute - Nampa — Nampa, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Nampa — Nampa, Idaho, United States
  • Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
  • Kootenai Cancer Clinic — Sandpoint, Idaho, United States
  • Saint Luke's Cancer Institute - Twin Falls — Twin Falls, Idaho, United States
  • Saint Anthony's Health — Alton, Illinois, United States
  • Rush - Copley Medical Center — Aurora, Illinois, United States
  • Illinois CancerCare-Bloomington — Bloomington, Illinois, United States
  • Illinois CancerCare-Canton — Canton, Illinois, United States
  • Memorial Hospital of Carbondale — Carbondale, Illinois, United States
  • SIH Cancer Institute — Carterville, Illinois, United States
  • Illinois CancerCare-Carthage — Carthage, Illinois, United States
  • Centralia Oncology Clinic — Centralia, Illinois, United States
  • Saint Mary's Hospital — Centralia, Illinois, United States
  • Northwestern University — Chicago, Illinois, United States
  • Carle at The Riverfront — Danville, Illinois, United States
  • Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois, United States
  • Decatur Memorial Hospital — Decatur, Illinois, United States
  • Illinois CancerCare-Dixon — Dixon, Illinois, United States
  • Carle Physician Group-Effingham — Effingham, Illinois, United States
  • Crossroads Cancer Center — Effingham, Illinois, United States
  • Illinois CancerCare-Eureka — Eureka, Illinois, United States
  • Illinois CancerCare-Galesburg — Galesburg, Illinois, United States
  • Western Illinois Cancer Treatment Center — Galesburg, Illinois, United States
  • Illinois CancerCare-Kewanee Clinic — Kewanee, Illinois, United States
  • Northwestern Medicine Lake Forest Hospital — Lake Forest, Illinois, United States
  • Illinois CancerCare-Macomb — Macomb, Illinois, United States
  • Good Samaritan Regional Health Center — Mount Vernon, Illinois, United States
  • Cancer Care Center of O'Fallon — O'Fallon, Illinois, United States
  • Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois, United States
  • Illinois CancerCare-Pekin — Pekin, Illinois, United States
  • Illinois CancerCare-Peoria — Peoria, Illinois, United States
  • Methodist Medical Center of Illinois — Peoria, Illinois, United States
  • Illinois CancerCare-Peru — Peru, Illinois, United States
  • Valley Radiation Oncology — Peru, Illinois, United States
  • Illinois CancerCare-Princeton — Princeton, Illinois, United States
  • Southern Illinois University School of Medicine — Springfield, Illinois, United States
  • Springfield Clinic — Springfield, Illinois, United States
  • Memorial Medical Center — Springfield, Illinois, United States
  • Southwest Illinois Health Services LLP — Swansea, Illinois, United States
  • Carle Cancer Center — Urbana, Illinois, United States
  • The Carle Foundation Hospital — Urbana, Illinois, United States
  • Illinois CancerCare - Washington — Washington, Illinois, United States
  • Rush-Copley Healthcare Center — Yorkville, Illinois, United States
  • Reid Health — Richmond, Indiana, United States
  • Mary Greeley Medical Center — Ames, Iowa, United States
  • McFarland Clinic - Ames — Ames, Iowa, United States
  • McFarland Clinic - Boone — Boone, Iowa, United States
  • Saint Anthony Regional Hospital — Carroll, Iowa, United States
  • Iowa Methodist Medical Center — Des Moines, Iowa, United States
  • Medical Oncology and Hematology Associates-Des Moines — Des Moines, Iowa, United States
  • Broadlawns Medical Center — Des Moines, Iowa, United States
  • Iowa Lutheran Hospital — Des Moines, Iowa, United States
  • McFarland Clinic - Trinity Cancer Center — Fort Dodge, Iowa, United States
  • Trinity Regional Medical Center — Fort Dodge, Iowa, United States
  • McFarland Clinic - Jefferson — Jefferson, Iowa, United States
  • McFarland Clinic - Marshalltown — Marshalltown, Iowa, United States
  • Methodist West Hospital — West Des Moines, Iowa, United States
  • Central Care Cancer Center - Garden City — Garden City, Kansas, United States
  • Central Care Cancer Center - Great Bend — Great Bend, Kansas, United States
  • Mercy Health - Paducah Medical Oncology and Hematology — Paducah, Kentucky, United States
  • University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
  • Bronson Battle Creek — Battle Creek, Michigan, United States
  • University of Michigan - Brighton Center for Specialty Care — Brighton, Michigan, United States
  • Helen DeVos Children's Hospital at Spectrum Health — Grand Rapids, Michigan, United States
  • Spectrum Health at Butterworth Campus — Grand Rapids, Michigan, United States
  • Trinity Health Grand Rapids Hospital — Grand Rapids, Michigan, United States
  • Bronson Methodist Hospital — Kalamazoo, Michigan, United States
  • West Michigan Cancer Center — Kalamazoo, Michigan, United States
  • Ascension Borgess Cancer Center — Kalamazoo, Michigan, United States
  • Borgess Medical Center — Kalamazoo, Michigan, United States
  • Trinity Health Muskegon Hospital — Muskegon, Michigan, United States
  • Lakeland Hospital Niles — Niles, Michigan, United States
  • Cancer and Hematology Centers of Western Michigan - Norton Shores — Norton Shores, Michigan, United States
  • Spectrum Health Reed City Hospital — Reed City, Michigan, United States
  • Lakeland Medical Center Saint Joseph — Saint Joseph, Michigan, United States
  • Marie Yeager Cancer Center — Saint Joseph, Michigan, United States
  • Munson Medical Center — Traverse City, Michigan, United States
  • University of Michigan Health - West — Wyoming, Michigan, United States
  • Fairview Ridges Hospital — Burnsville, Minnesota, United States
  • Minnesota Oncology - Burnsville — Burnsville, Minnesota, United States
  • Cambridge Medical Center — Cambridge, Minnesota, United States
  • Mercy Hospital — Coon Rapids, Minnesota, United States
  • Fairview Southdale Hospital — Edina, Minnesota, United States
  • Unity Hospital — Fridley, Minnesota, United States
  • Fairview Clinics and Surgery Center Maple Grove — Maple Grove, Minnesota, United States
  • Minnesota Oncology Hematology PA-Maplewood — Maplewood, Minnesota, United States
  • Saint John's Hospital - Healtheast — Maplewood, Minnesota, United States
  • Abbott-Northwestern Hospital — Minneapolis, Minnesota, United States
  • Hennepin County Medical Center — Minneapolis, Minnesota, United States
  • Health Partners Inc — Minneapolis, Minnesota, United States
  • Monticello Cancer Center — Monticello, Minnesota, United States
  • New Ulm Medical Center — New Ulm, Minnesota, United States
  • Fairview Northland Medical Center — Princeton, Minnesota, United States
  • North Memorial Medical Health Center — Robbinsdale, Minnesota, United States
  • Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
  • Regions Hospital — Saint Paul, Minnesota, United States
  • United Hospital — Saint Paul, Minnesota, United States
  • Saint Francis Regional Medical Center — Shakopee, Minnesota, United States
  • Lakeview Hospital — Stillwater, Minnesota, United States
  • Ridgeview Medical Center — Waconia, Minnesota, United States
  • Rice Memorial Hospital — Willmar, Minnesota, United States
  • Minnesota Oncology Hematology PA-Woodbury — Woodbury, Minnesota, United States
  • Fairview Lakes Medical Center — Wyoming, Minnesota, United States
  • Saint Louis Cancer and Breast Institute-Ballwin — Ballwin, Missouri, United States
  • Central Care Cancer Center - Bolivar — Bolivar, Missouri, United States
  • Cox Cancer Center Branson — Branson, Missouri, United States
  • Saint Francis Medical Center — Cape Girardeau, Missouri, United States
  • Southeast Cancer Center — Cape Girardeau, Missouri, United States
  • Parkland Health Center - Farmington — Farmington, Missouri, United States
  • Capital Region Southwest Campus — Jefferson City, Missouri, United States
  • Freeman Health System — Joplin, Missouri, United States
  • Mercy Hospital Joplin — Joplin, Missouri, United States
  • Delbert Day Cancer Institute at PCRMC — Rolla, Missouri, United States
  • Mercy Clinic-Rolla-Cancer and Hematology — Rolla, Missouri, United States
  • Heartland Regional Medical Center — Saint Joseph, Missouri, United States
  • Sainte Genevieve County Memorial Hospital — Sainte Genevieve, Missouri, United States
  • Mercy Hospital Springfield — Springfield, Missouri, United States
  • CoxHealth South Hospital — Springfield, Missouri, United States
  • Saint Louis Cancer and Breast Institute-South City — St Louis, Missouri, United States
  • Mercy Hospital South — St Louis, Missouri, United States
  • Missouri Baptist Medical Center — St Louis, Missouri, United States
  • Mercy Hospital Saint Louis — St Louis, Missouri, United States
  • Missouri Baptist Sullivan Hospital — Sullivan, Missouri, United States
  • Missouri Baptist Outpatient Center-Sunset Hills — Sunset Hills, Missouri, United States
  • Mercy Hospital Washington — Washington, Missouri, United States
  • Community Hospital of Anaconda — Anaconda, Montana, United States
  • Billings Clinic Cancer Center — Billings, Montana, United States
  • Bozeman Deaconess Hospital — Bozeman, Montana, United States
  • Benefis Healthcare- Sletten Cancer Institute — Great Falls, Montana, United States
  • Great Falls Clinic — Great Falls, Montana, United States
  • Kalispell Regional Medical Center — Kalispell, Montana, United States
  • Saint Patrick Hospital - Community Hospital — Missoula, Montana, United States
  • Community Medical Hospital — Missoula, Montana, United States
  • Cancer Partners of Nebraska - Pine Lake — Lincoln, Nebraska, United States
  • Southeast Nebraska Cancer Center - 68th Street Place — Lincoln, Nebraska, United States
  • Roswell Park Cancer Institute — Buffalo, New York, United States
  • Wake Forest University at Clemmons — Clemmons, North Carolina, United States
  • Southeastern Medical Oncology Center-Clinton — Clinton, North Carolina, United States
  • Southeastern Medical Oncology Center-Goldsboro — Goldsboro, North Carolina, United States
  • Southeastern Medical Oncology Center-Jacksonville — Jacksonville, North Carolina, United States
  • Wake Forest Baptist Health - Hematology Oncology - Statesville — Statesville, North Carolina, United States
  • Wake Forest Baptist Health - Wilkes Medical Center — Wilkesboro, North Carolina, United States
  • Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
  • UHHS-Chagrin Highlands Medical Center — Beachwood, Ohio, United States
  • Indu and Raj Soin Medical Center — Beavercreek, Ohio, United States
  • Strecker Cancer Center-Belpre — Belpre, Ohio, United States
  • Saint Elizabeth Boardman Hospital — Boardman, Ohio, United States
  • Dayton Physicians LLC-Miami Valley South — Centerville, Ohio, United States
  • Miami Valley Hospital South — Centerville, Ohio, United States
  • Geauga Hospital — Chardon, Ohio, United States
  • Adena Regional Medical Center — Chillicothe, Ohio, United States
  • University of Cincinnati Cancer Center-UC Medical Center — Cincinnati, Ohio, United States
  • Oncology Hematology Care Inc-Kenwood — Cincinnati, Ohio, United States
  • Case Western Reserve University — Cleveland, Ohio, United States
  • Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
  • Mount Carmel East Hospital — Columbus, Ohio, United States
  • Columbus Oncology and Hematology Associates Inc — Columbus, Ohio, United States
  • Riverside Methodist Hospital — Columbus, Ohio, United States
  • Grant Medical Center — Columbus, Ohio, United States
  • The Mark H Zangmeister Center — Columbus, Ohio, United States
  • Mount Carmel Health Center West — Columbus, Ohio, United States
  • Doctors Hospital — Columbus, Ohio, United States
  • Miami Valley Hospital — Dayton, Ohio, United States
  • Dayton Physician LLC-Miami Valley Hospital North — Dayton, Ohio, United States
  • Miami Valley Hospital North — Dayton, Ohio, United States
  • Delaware Health Center-Grady Cancer Center — Delaware, Ohio, United States
  • Grady Memorial Hospital — Delaware, Ohio, United States
  • Columbus Oncology and Hematology Associates — Dublin, Ohio, United States
  • Dublin Methodist Hospital — Dublin, Ohio, United States
  • Armes Family Cancer Center — Findlay, Ohio, United States
  • Blanchard Valley Hospital — Findlay, Ohio, United States
  • Orion Cancer Care — Findlay, Ohio, United States
  • Atrium Medical Center-Middletown Regional Hospital — Franklin, Ohio, United States
  • Dayton Physicians LLC-Atrium — Franklin, Ohio, United States
  • Central Ohio Breast and Endocrine Surgery — Gahanna, Ohio, United States
  • Dayton Physicians LLC-Wayne — Greenville, Ohio, United States
  • Wayne Hospital — Greenville, Ohio, United States
  • Mount Carmel Grove City Hospital — Grove City, Ohio, United States
  • Zangmeister Center Grove City — Grove City, Ohio, United States
  • Greater Dayton Cancer Center — Kettering, Ohio, United States
  • Kettering Medical Center — Kettering, Ohio, United States
  • Fairfield Medical Center — Lancaster, Ohio, United States
  • Saint Rita's Medical Center — Lima, Ohio, United States
  • OhioHealth Mansfield Hospital — Mansfield, Ohio, United States
  • Marietta Memorial Hospital — Marietta, Ohio, United States
  • OhioHealth Marion General Hospital — Marion, Ohio, United States
  • UH Seidman Cancer Center at Southwest General Hospital — Middleburg Heights, Ohio, United States
  • Knox Community Hospital — Mount Vernon, Ohio, United States
  • Mount Carmel New Albany Surgical Hospital — New Albany, Ohio, United States
  • Licking Memorial Hospital — Newark, Ohio, United States
  • Newark Radiation Oncology — Newark, Ohio, United States
  • University Hospitals Parma Medical Center — Parma, Ohio, United States
  • Mercy Health Perrysburg Cancer Center — Perrysburg, Ohio, United States
  • Southern Ohio Medical Center — Portsmouth, Ohio, United States
  • University Hospitals Portage Medical Center — Ravenna, Ohio, United States
  • UH Seidman Cancer Center at Firelands Regional Medical Center — Sandusky, Ohio, United States
  • Springfield Regional Cancer Center — Springfield, Ohio, United States
  • Springfield Regional Medical Center — Springfield, Ohio, United States
  • Saint Vincent Mercy Medical Center — Toledo, Ohio, United States
  • Mercy Health - Saint Anne Hospital — Toledo, Ohio, United States
  • Dayton Physicians LLC - Troy — Troy, Ohio, United States
  • Upper Valley Medical Center — Troy, Ohio, United States
  • University Hospitals Sharon Health Center — Wadsworth, Ohio, United States
  • Saint Joseph Warren Hospital — Warren, Ohio, United States
  • University of Cincinnati Cancer Center-West Chester — West Chester, Ohio, United States
  • Saint Ann's Hospital — Westerville, Ohio, United States
  • UH Seidman Cancer Center at Saint John Medical Center — Westlake, Ohio, United States
  • Saint Elizabeth Youngstown Hospital — Youngstown, Ohio, United States
  • Genesis Healthcare System Cancer Care Center — Zanesville, Ohio, United States
  • University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
  • Mercy Hospital Oklahoma City — Oklahoma City, Oklahoma, United States
  • Saint Alphonsus Medical Center-Baker City — Baker City, Oregon, United States
  • Saint Charles Health System — Bend, Oregon, United States
  • Clackamas Radiation Oncology Center — Clackamas, Oregon, United States
  • Providence Cancer Institute Clackamas Clinic — Clackamas, Oregon, United States
  • Bay Area Hospital — Coos Bay, Oregon, United States
  • Providence Newberg Medical Center — Newberg, Oregon, United States
  • Saint Alphonsus Medical Center-Ontario — Ontario, Oregon, United States
  • Providence Willamette Falls Medical Center — Oregon City, Oregon, United States
  • Providence Portland Medical Center — Portland, Oregon, United States
  • Providence Saint Vincent Medical Center — Portland, Oregon, United States
  • Saint Charles Health System-Redmond — Redmond, Oregon, United States
  • University of Pittsburgh Cancer Institute (UPCI) — Pittsburgh, Pennsylvania, United States
  • Avera Cancer Institute — Sioux Falls, South Dakota, United States
  • Huntsman Cancer Institute/University of Utah — Salt Lake City, Utah, United States
  • Providence Regional Cancer System-Aberdeen — Aberdeen, Washington, United States
  • PeaceHealth Saint Joseph Medical Center — Bellingham, Washington, United States
  • Providence Regional Cancer System-Centralia — Centralia, Washington, United States
  • Swedish Cancer Institute-Edmonds — Edmonds, Washington, United States
  • Providence Regional Cancer Partnership — Everett, Washington, United States
  • Swedish Cancer Institute-Issaquah — Issaquah, Washington, United States
  • Kadlec Clinic Hematology and Oncology — Kennewick, Washington, United States
  • Providence Regional Cancer System-Lacey — Lacey, Washington, United States
  • PeaceHealth Saint John Medical Center — Longview, Washington, United States
  • Jefferson Healthcare — Port Townsend, Washington, United States
  • Pacific Gynecology Specialists — Seattle, Washington, United States
  • Swedish Medical Center-Ballard Campus — Seattle, Washington, United States
  • Swedish Medical Center-Cherry Hill — Seattle, Washington, United States
  • Swedish Medical Center-First Hill — Seattle, Washington, United States
  • PeaceHealth United General Medical Center — Sedro-Woolley, Washington, United States
  • Providence Regional Cancer System-Shelton — Shelton, Washington, United States
  • PeaceHealth Southwest Medical Center — Vancouver, Washington, United States
  • Providence Saint Mary Regional Cancer Center — Walla Walla, Washington, United States
  • Providence Regional Cancer System-Yelm — Yelm, Washington, United States
  • Langlade Hospital and Cancer Center — Antigo, Wisconsin, United States
  • Marshfield Medical Center-EC Cancer Center — Eau Claire, Wisconsin, United States
  • Gundersen Lutheran Medical Center — La Crosse, Wisconsin, United States
  • University of Wisconsin Carbone Cancer Center — Madison, Wisconsin, United States
  • Marshfield Medical Center-Marshfield — Marshfield, Wisconsin, United States
  • Aspirus Medford Hospital — Medford, Wisconsin, United States
  • Marshfield Clinic-Minocqua Center — Minocqua, Wisconsin, United States
  • Cancer Center of Western Wisconsin — New Richmond, Wisconsin, United States
  • Marshfield Medical Center-Rice Lake — Rice Lake, Wisconsin, United States
  • Ascension Saint Michael's Hospital — Stevens Point, Wisconsin, United States
  • Marshfield Medical Center-River Region at Stevens Point — Stevens Point, Wisconsin, United States
  • Aspirus Regional Cancer Center — Wausau, Wisconsin, United States
  • Marshfield Medical Center - Weston — Weston, Wisconsin, United States
  • Aspirus Cancer Care - Wisconsin Rapids — Wisconsin Rapids, Wisconsin, United States
  • Cheyenne Regional Medical Center-West — Cheyenne, Wyoming, United States
  • Billings Clinic-Cody — Cody, Wyoming, United States
  • Welch Cancer Center — Sheridan, Wyoming, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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