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RECRUITING Phase 3 ClinicalTrials.gov

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

Sponsor: SWOG Cancer Research Network • ClinicalTrials.gov ID: NCT04510597

Registry updated: 2026-10-08
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Description

This phase III trial compares the effect of adding surgery to a standard of care immunotherapy-based drug combination versus a standard of care immunotherapy-based drug combination alone in treating patients with kidney cancer that has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, pembrolizumab, and avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Axitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Surgery to remove the kidney, called a nephrectomy, is also considered standard of care; however, doctors who treat kidney cancer do not agree on its benefits. It is not yet known if the addition of surgery to an immunotherapy-based drug combination works better than an immunotherapy-based drug combination alone in treating patients with kidney cancer.

Interventions

  • Cytoreductive Nephrectomy (Procedure)
    Radical or partial nephrectomy may be performed using laparoscopic, open, or robotic approaches. Surgery should be performed within 8 weeks of randomization
  • Active Comparator (Drug)
    Nivolumab 240 mg IV 1 q 2 weeks OR Nivolumab 480 mg IV 1 q 4 weeks OR Pembrolizumab 200 mg IV 1 q 3 weeks Axitinib 5 mg oral Daily BID OR Avelumab 10 mg/kg IV 1 q 2 weeks Axitinib 5 mg oral Daily BID

Eligibility criteria

Inclusion Criteria: * STEP 1 REGISTRATION: Participants must have a histologically proven diagnosis of clear cell or non-clear cell renal cell carcinoma. Participants with collecting duct carcinoma histology are not eligible. Participants with multifocal or bilateral tumors are eligible * STEP 1 REGISTRATION: Participants must have primary tumor in place * STEP 1 REGISTRATION: Participants must have the following scans performed, showing clinical evidence of measurable or non-measurable metastatic disease: * Computed tomography (CT) scan of the chest (can be performed without contrast if CT contrast cannot be given) * CT of abdomen and pelvis with contrast OR magnetic resonance imaging (MRI) of the abdomen and pelvis with or without contrast Scans must be performed within the following timeframes: * Treatment naive participants must have scans documenting metastatic disease completed within 90 days prior to study registration * Previously treated participants must have scans documenting metastatic disease completed within 90 days prior to first dose of systemic treatment * STEP 1 REGISTRATION: Participants with symptomatic metastases may have received palliative radiotherapy or receive palliative radiotherapy after registration * STEP 1 REGISTRATION: Participants must have no clear contraindications to nephrectomy * STEP 1 REGISTRATION: Participants must be offered the opportunity to participate in specimen bank. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System * STEP 1 REGISTRATION: Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines * STEP 1 REGISTRATION: As part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system * STEP 2 REGISTRATION: Participants must have at least one of the following scans performed 12 weeks (+/- 2 weeks) after starting pre-randomization treatment * CT scan of the chest (can be performed without contrast if CT contrast cannot be given) * CT of abdomen and pelvis with contrast OR MRI of the abdomen and pelvis with or without contrast Scans must be performed within 28 days prior to randomization. Response should be assessed by comparing with a CT or MRI of the chest, abdomen and pelvis obtained prior to starting pre-randomization treatment. Participants with complete response in all metastatic sites are not eligible to randomize to Step 2 • STEP 2 REGISTRATION: Participants must have one of the following objective statuses after 12 weeks of pre-randomization treatment * Stable disease * Partial response * The treating investigator believes the patient is deriving clinical benefit from systemic therapy AND have Zubrod performance status 0-1 * STEP 2 REGISTRATION: Participants must plan to continue the immune-based therapy received during pre-randomization treatment * STEP 2 REGISTRATION: Participants must be randomized on or between the 11th and 14th week of protocol-directed pre-randomization treatment therapy * STEP 2 REGISTRATION: Participants must have received at least one of the minimum amounts of immunotherapy: * 2 infusions of nivolumab + 1 infusion of ipilimumab * 2 infusions of pembrolizumab * 2 infusions of avelumab * STEP 2 REGISTRATION: Participants must have a planned surgery date within 42 days of randomization * STEP 2 REGISTRATION: Participants must be a surgical candidate as determined by study urologist. The urology consult should be done within 42 days prior to randomization * STEP 2 REGISTRATION: Participants must have a complete physical examination and medical history within 28 days prior to randomization * STEP 2 REGISTRATION: Participants must have a Zubrod performance status of 0-1 within 28 days prior to randomization * STEP 2 REGISTRATION: Total bilirubin =\< institutional upper limit of normal (ULN) (within 28 days prior to randomization) * STEP 2 REGISTRATION: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =\< 3 x institutional upper limit of normal (ULN) (within 28 days prior to randomization) * STEP 2 REGISTRATION: Serum creatinine =\< 1.5 x the institutional upper limit of normal (IULN) OR measured OR calculated creatinine clearance \>= 50 mL/min using the Cockcroft-Gault Formula) (must have been drawn and processed within 28 days prior to randomization) Exclusion Criteria: * STEP 1 REGISTRATION: Participants must not have known active brain metastases. Participants with previously treated brain metastases are eligible if participant has no neurologic signs or symptoms suggestive of brain metastasis. Brain imaging studies are not required. If brain imaging studies are performed, they must be negative for disease * STEP 1 REGISTRATION: Participants must not have received the following prior treatment of metastatic renal cell carcinoma: * Treatment naive participants must not have received any prior lines of systemic therapy for metastatic renal cell carcinoma beyond the line intended as part of protocol therapy * Previously treated participants must not have received any systemic therapy for metastatic renal cell carcinoma beyond the one regimen received off protocol as specified in Step 1 pre-randomization treatment * STEP 1 REGISTRATION: Participants must not have received more than the following amounts protocol-directed pre-randomization treatment: * Treatment naive participants must not have received any pre-randomization treatment. * Previously treated participants must not be planning to receive any additional treatment prior to Step 2 randomization, and must not have received more than the following amounts of pre-randomization treatment: * 4 infusions of nivolumab * 4 infusions of ipilimumab * 4 infusions of pembrolizumab * 7 infusions of avelumab * STEP 1 REGISTRATION: Participants must not have received immunotherapy for any cancer within the following timeframes: * Treatment naive participants must not have received any immunotherapy within a year of registration * Previously treated participants must not have received any other immunotherapy within a year of the start of off protocol specified pre-randomization treatment * STEP 1 REGISTRATION: Participants must not have a solitary kidney and not have a transplanted kidney * STEP 1 REGISTRATION: No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, any in situ or T1 cancer, adequately treated stage I or II cancer from which the participant is currently in complete remission, or any other cancer from which the participant has been disease free for at least two years * STEP 1 REGISTRATION: Participants must not have been previously diagnosed with a medical condition that makes them ineligible for immune based combination therapy or nephrectomy * STEP 2 REGISTRATION: Participants must not show progression in the primary tumor. Participants who are considered to have pseudo progression are allowed * STEP 2 REGISTRATION: Participants must not have known active brain metastases. Participants with previously treated brain metastases are eligible if participant has no neurologic signs or symptoms suggestive of brain metastasis. Brain imaging studies are not required. If brain imaging studies are performed, they must be negative for disease * STEP 2 REGISTRATION: No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the participant is currently in complete remission, or any other cancer from which the participant has been disease free for two years

Conditions

Metastatic Clear Cell Renal Cell Carcinoma Metastatic Renal Cell Carcinoma Stage IV Renal Cell Cancer AJCC v8

Locations

  • University of Alabama at Birmingham Cancer Center — Birmingham, Alabama, United States
  • Banner MD Anderson Cancer Center — Gilbert, Arizona, United States
  • Kingman Regional Medical Center — Kingman, Arizona, United States
  • Banner University Medical Center - Tucson — Tucson, Arizona, United States
  • University of Arizona Cancer Center-North Campus — Tucson, Arizona, United States
  • Mercy Hospital Fort Smith — Fort Smith, Arkansas, United States
  • PCR Oncology — Arroyo Grande, California, United States
  • Sutter Auburn Faith Hospital — Auburn, California, United States
  • Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California, United States
  • Alta Bates Summit Medical Center-Herrick Campus — Berkeley, California, United States
  • Keck Medicine of USC Buena Park — Buena Park, California, United States
  • Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park, California, United States
  • Eden Hospital Medical Center — Castro Valley, California, United States
  • Sutter Davis Hospital — Davis, California, United States
  • City of Hope Comprehensive Cancer Center — Duarte, California, United States
  • Palo Alto Medical Foundation-Fremont — Fremont, California, United States
  • Keck Medicine of USC Huntington Beach — Huntington Beach, California, United States
  • Keck Medicine of USC Koreatown — Los Angeles, California, United States
  • Los Angeles County-USC Medical Center — Los Angeles, California, United States
  • USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
  • Cedars Sinai Medical Center — Los Angeles, California, United States
  • UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California, United States
  • Memorial Medical Center — Modesto, California, United States
  • Palo Alto Medical Foundation-Camino Division — Mountain View, California, United States
  • Palo Alto Medical Foundation-Gynecologic Oncology — Mountain View, California, United States
  • USC Norris Oncology/Hematology-Newport Beach — Newport Beach, California, United States
  • Sutter Cancer Research Consortium — Novato, California, United States
  • Palo Alto Medical Foundation Health Care — Palo Alto, California, United States
  • Keck Medical Center of USC Pasadena — Pasadena, California, United States
  • Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California, United States
  • Sutter Roseville Medical Center — Roseville, California, United States
  • Sutter Medical Center Sacramento — Sacramento, California, United States
  • University of California Davis Comprehensive Cancer Center — Sacramento, California, United States
  • California Pacific Medical Center-Pacific Campus — San Francisco, California, United States
  • Mills Health Center — San Mateo, California, United States
  • Palo Alto Medical Foundation-Santa Cruz — Santa Cruz, California, United States
  • Sutter Pacific Medical Foundation — Santa Rosa, California, United States
  • City of Hope South Pasadena — South Pasadena, California, United States
  • Palo Alto Medical Foundation-Sunnyvale — Sunnyvale, California, United States
  • Cedars-Sinai Cancer - Tarzana — Tarzana, California, United States
  • City of Hope Upland — Upland, California, United States
  • Sutter Cancer Centers Radiation Oncology Services-Vacaville — Vacaville, California, United States
  • Sutter Solano Medical Center/Cancer Center — Vallejo, California, United States
  • MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
  • AdventHealth Altamonte — Altamonte Springs, Florida, United States
  • AdventHealth Celebration — Celebration, Florida, United States
  • AdventHealth Kissimmee — Kissimmee, Florida, United States
  • AdventHealth Medical Group Urology at Orlando — Orlando, Florida, United States
  • AdventHealth Orlando — Orlando, Florida, United States
  • Orlando Health Cancer Institute — Orlando, Florida, United States
  • AdventHealth East Orlando — Orlando, Florida, United States
  • AdventHealth Winter Park — Winter Park, Florida, United States
  • Saint Anthony's Health — Alton, Illinois, United States
  • Rush - Copley Medical Center — Aurora, Illinois, United States
  • Advocate Good Shepherd Hospital — Barrington, Illinois, United States
  • Illinois CancerCare-Bloomington — Bloomington, Illinois, United States
  • Loyola Center for Health at Burr Ridge — Burr Ridge, Illinois, United States
  • Illinois CancerCare-Canton — Canton, Illinois, United States
  • Memorial Hospital of Carbondale — Carbondale, Illinois, United States
  • SIH Cancer Institute — Carterville, Illinois, United States
  • Illinois CancerCare-Carthage — Carthage, Illinois, United States
  • Centralia Oncology Clinic — Centralia, Illinois, United States
  • Saint Mary's Hospital — Centralia, Illinois, United States
  • Northwestern University — Chicago, Illinois, United States
  • Rush University Medical Center — Chicago, Illinois, United States
  • University of Illinois — Chicago, Illinois, United States
  • University of Chicago Comprehensive Cancer Center — Chicago, Illinois, United States
  • Advocate Illinois Masonic Medical Center — Chicago, Illinois, United States
  • AMG Crystal Lake - Oncology — Crystal Lake, Illinois, United States
  • Carle at The Riverfront — Danville, Illinois, United States
  • Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois, United States
  • Decatur Memorial Hospital — Decatur, Illinois, United States
  • Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois, United States
  • Illinois CancerCare-Dixon — Dixon, Illinois, United States
  • Advocate Good Samaritan Hospital — Downers Grove, Illinois, United States
  • Carle Physician Group-Effingham — Effingham, Illinois, United States
  • Crossroads Cancer Center — Effingham, Illinois, United States
  • Advocate Sherman Hospital — Elgin, Illinois, United States
  • Elmhurst Memorial Hospital — Elmhurst, Illinois, United States
  • Illinois CancerCare-Eureka — Eureka, Illinois, United States
  • Illinois CancerCare-Galesburg — Galesburg, Illinois, United States
  • Western Illinois Cancer Treatment Center — Galesburg, Illinois, United States
  • Northwestern Medicine Cancer Center Delnor — Geneva, Illinois, United States
  • Advocate South Suburban Hospital — Hazel Crest, Illinois, United States
  • Loyola Medicine Homer Glen — Homer Glen, Illinois, United States
  • Illinois CancerCare-Kewanee Clinic — Kewanee, Illinois, United States
  • Northwestern Medicine Lake Forest Hospital — Lake Forest, Illinois, United States
  • AMG Libertyville - Oncology — Libertyville, Illinois, United States
  • Condell Memorial Hospital — Libertyville, Illinois, United States
  • Illinois CancerCare-Macomb — Macomb, Illinois, United States
  • Carle Physician Group-Mattoon/Charleston — Mattoon, Illinois, United States
  • Loyola University Medical Center — Maywood, Illinois, United States
  • Marjorie Weinberg Cancer Center at Loyola-Gottlieb — Melrose Park, Illinois, United States
  • Good Samaritan Regional Health Center — Mount Vernon, Illinois, United States
  • Edward Hospital/Cancer Center — Naperville, Illinois, United States
  • UC Comprehensive Cancer Center at Silver Cross — New Lenox, Illinois, United States
  • Cancer Care Center of O'Fallon — O'Fallon, Illinois, United States
  • Advocate Christ Medical Center — Oak Lawn, Illinois, United States
  • University of Chicago Medicine-Orland Park — Orland Park, Illinois, United States
  • Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois, United States
  • Advocate Lutheran General Hospital — Park Ridge, Illinois, United States
  • Illinois CancerCare-Pekin — Pekin, Illinois, United States
  • Illinois CancerCare-Peoria — Peoria, Illinois, United States
  • Methodist Medical Center of Illinois — Peoria, Illinois, United States
  • Illinois CancerCare-Peru — Peru, Illinois, United States
  • Valley Radiation Oncology — Peru, Illinois, United States
  • Edward Hospital/Cancer Center?Plainfield — Plainfield, Illinois, United States
  • Illinois CancerCare-Princeton — Princeton, Illinois, United States
  • Southern Illinois University School of Medicine — Springfield, Illinois, United States
  • Springfield Clinic — Springfield, Illinois, United States
  • Memorial Medical Center — Springfield, Illinois, United States
  • Carle Cancer Center — Urbana, Illinois, United States
  • The Carle Foundation Hospital — Urbana, Illinois, United States
  • Northwestern Medicine Cancer Center Warrenville — Warrenville, Illinois, United States
  • Illinois CancerCare - Washington — Washington, Illinois, United States
  • Rush-Copley Healthcare Center — Yorkville, Illinois, United States
  • Reid Health — Richmond, Indiana, United States
  • Mary Greeley Medical Center — Ames, Iowa, United States
  • McFarland Clinic - Ames — Ames, Iowa, United States
  • McFarland Clinic - Boone — Boone, Iowa, United States
  • Saint Anthony Regional Hospital — Carroll, Iowa, United States
  • Iowa Methodist Medical Center — Des Moines, Iowa, United States
  • Medical Oncology and Hematology Associates-Des Moines — Des Moines, Iowa, United States
  • Broadlawns Medical Center — Des Moines, Iowa, United States
  • Iowa Lutheran Hospital — Des Moines, Iowa, United States
  • McFarland Clinic - Trinity Cancer Center — Fort Dodge, Iowa, United States
  • Trinity Regional Medical Center — Fort Dodge, Iowa, United States
  • McFarland Clinic - Jefferson — Jefferson, Iowa, United States
  • McFarland Clinic - Marshalltown — Marshalltown, Iowa, United States
  • Methodist West Hospital — West Des Moines, Iowa, United States
  • Central Care Cancer Center - Garden City — Garden City, Kansas, United States
  • Central Care Cancer Center - Great Bend — Great Bend, Kansas, United States
  • University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
  • Hematology/Oncology Clinic PLLC — Baton Rouge, Louisiana, United States
  • East Jefferson General Hospital — Metairie, Louisiana, United States
  • LSU Healthcare Network / Metairie Multi-Specialty Clinic — Metairie, Louisiana, United States
  • Louisiana State University Health Science Center — New Orleans, Louisiana, United States
  • Tulane University Health Sciences Center — New Orleans, Louisiana, United States
  • University Medical Center New Orleans — New Orleans, Louisiana, United States
  • University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
  • Bronson Battle Creek — Battle Creek, Michigan, United States
  • University of Michigan - Brighton Center for Specialty Care — Brighton, Michigan, United States
  • Henry Ford Cancer Institute-Downriver — Brownstown, Michigan, United States
  • Henry Ford Hematology Oncology - Hayes — Clinton Township, Michigan, United States
  • Henry Ford Macomb Hospital-Clinton Township — Clinton Township, Michigan, United States
  • Henry Ford Medical Center-Fairlane — Dearborn, Michigan, United States
  • Henry Ford Hospital — Detroit, Michigan, United States
  • Helen DeVos Children's Hospital at Spectrum Health — Grand Rapids, Michigan, United States
  • Spectrum Health at Butterworth Campus — Grand Rapids, Michigan, United States
  • Trinity Health Grand Rapids Hospital — Grand Rapids, Michigan, United States
  • Allegiance Health — Jackson, Michigan, United States
  • Bronson Methodist Hospital — Kalamazoo, Michigan, United States
  • West Michigan Cancer Center — Kalamazoo, Michigan, United States
  • Ascension Borgess Cancer Center — Kalamazoo, Michigan, United States
  • Borgess Medical Center — Kalamazoo, Michigan, United States
  • Trinity Health Muskegon Hospital — Muskegon, Michigan, United States
  • Lakeland Hospital Niles — Niles, Michigan, United States
  • Cancer and Hematology Centers of Western Michigan - Norton Shores — Norton Shores, Michigan, United States
  • Henry Ford Medical Center-Columbus — Novi, Michigan, United States
  • Spectrum Health Reed City Hospital — Reed City, Michigan, United States
  • Lakeland Medical Center Saint Joseph — Saint Joseph, Michigan, United States
  • Marie Yeager Cancer Center — Saint Joseph, Michigan, United States
  • Henry Ford Macomb Health Center - Shelby Township — Shelby, Michigan, United States
  • Munson Medical Center — Traverse City, Michigan, United States
  • Henry Ford West Bloomfield Hospital — West Bloomfield, Michigan, United States
  • Henry Ford Wyandotte Hospital — Wyandotte, Michigan, United States
  • University of Michigan Health - West — Wyoming, Michigan, United States
  • Fairview Ridges Hospital — Burnsville, Minnesota, United States
  • Minnesota Oncology - Burnsville — Burnsville, Minnesota, United States
  • Cambridge Medical Center — Cambridge, Minnesota, United States
  • Mercy Hospital — Coon Rapids, Minnesota, United States
  • Fairview Southdale Hospital — Edina, Minnesota, United States
  • Unity Hospital — Fridley, Minnesota, United States
  • Fairview Clinics and Surgery Center Maple Grove — Maple Grove, Minnesota, United States
  • Minnesota Oncology Hematology PA-Maplewood — Maplewood, Minnesota, United States
  • Saint John's Hospital - Healtheast — Maplewood, Minnesota, United States
  • Abbott-Northwestern Hospital — Minneapolis, Minnesota, United States
  • Hennepin County Medical Center — Minneapolis, Minnesota, United States
  • Health Partners Inc — Minneapolis, Minnesota, United States
  • Monticello Cancer Center — Monticello, Minnesota, United States
  • New Ulm Medical Center — New Ulm, Minnesota, United States
  • Fairview Northland Medical Center — Princeton, Minnesota, United States
  • North Memorial Medical Health Center — Robbinsdale, Minnesota, United States
  • Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
  • Regions Hospital — Saint Paul, Minnesota, United States
  • United Hospital — Saint Paul, Minnesota, United States
  • Saint Francis Regional Medical Center — Shakopee, Minnesota, United States
  • Lakeview Hospital — Stillwater, Minnesota, United States
  • Ridgeview Medical Center — Waconia, Minnesota, United States
  • Rice Memorial Hospital — Willmar, Minnesota, United States
  • Minnesota Oncology Hematology PA-Woodbury — Woodbury, Minnesota, United States
  • Fairview Lakes Medical Center — Wyoming, Minnesota, United States
  • Gulfport Memorial Hospital — Gulfport, Mississippi, United States
  • Saint Louis Cancer and Breast Institute-Ballwin — Ballwin, Missouri, United States
  • Central Care Cancer Center - Bolivar — Bolivar, Missouri, United States
  • Cox Cancer Center Branson — Branson, Missouri, United States
  • Saint Francis Medical Center — Cape Girardeau, Missouri, United States
  • Southeast Cancer Center — Cape Girardeau, Missouri, United States
  • Parkland Health Center - Farmington — Farmington, Missouri, United States
  • Capital Region Southwest Campus — Jefferson City, Missouri, United States
  • Freeman Health System — Joplin, Missouri, United States
  • Mercy Hospital Joplin — Joplin, Missouri, United States
  • Delbert Day Cancer Institute at PCRMC — Rolla, Missouri, United States
  • Mercy Clinic-Rolla-Cancer and Hematology — Rolla, Missouri, United States
  • Heartland Regional Medical Center — Saint Joseph, Missouri, United States
  • Sainte Genevieve County Memorial Hospital — Sainte Genevieve, Missouri, United States
  • Mercy Hospital Springfield — Springfield, Missouri, United States
  • CoxHealth South Hospital — Springfield, Missouri, United States
  • Saint Louis Cancer and Breast Institute-South City — St Louis, Missouri, United States
  • Mercy Hospital South — St Louis, Missouri, United States
  • Missouri Baptist Medical Center — St Louis, Missouri, United States
  • Mercy Hospital Saint Louis — St Louis, Missouri, United States
  • Missouri Baptist Sullivan Hospital — Sullivan, Missouri, United States
  • Missouri Baptist Outpatient Center-Sunset Hills — Sunset Hills, Missouri, United States
  • Mercy Hospital Washington — Washington, Missouri, United States
  • Nebraska Cancer Specialists/Oncology Hematology West PC - MECC — Omaha, Nebraska, United States
  • Nebraska Methodist Hospital — Omaha, Nebraska, United States
  • Oncology Associates PC — Omaha, Nebraska, United States
  • Carson Tahoe Regional Medical Center — Carson City, Nevada, United States
  • Cancer and Blood Specialists-Henderson — Henderson, Nevada, United States
  • Comprehensive Cancer Centers of Nevada - Henderson — Henderson, Nevada, United States
  • Comprehensive Cancer Centers of Nevada-Horizon Ridge — Henderson, Nevada, United States
  • Las Vegas Cancer Center-Henderson — Henderson, Nevada, United States
  • OptumCare Cancer Care at Seven Hills — Henderson, Nevada, United States
  • Comprehensive Cancer Centers of Nevada-Southeast Henderson — Henderson, Nevada, United States
  • GenesisCare USA - Henderson — Henderson, Nevada, United States
  • Las Vegas Urology - Green Valley — Henderson, Nevada, United States
  • Las Vegas Urology - Pebble — Henderson, Nevada, United States
  • Urology Specialists of Nevada - Green Valley — Henderson, Nevada, United States
  • Las Vegas Urology - Pecos — Las Vegas, Nevada, United States
  • Desert West Surgery — Las Vegas, Nevada, United States
  • OptumCare Cancer Care at Charleston — Las Vegas, Nevada, United States
  • University Medical Center of Southern Nevada — Las Vegas, Nevada, United States
  • Hope Cancer Care of Nevada — Las Vegas, Nevada, United States
  • Radiation Oncology Centers of Nevada Central — Las Vegas, Nevada, United States
  • Urology Specialists of Nevada - Central — Las Vegas, Nevada, United States
  • GenesisCare USA - Las Vegas — Las Vegas, Nevada, United States
  • Sunrise Hospital and Medical Center — Las Vegas, Nevada, United States
  • Las Vegas Prostate Cancer Center — Las Vegas, Nevada, United States
  • Las Vegas Urology - Sunset — Las Vegas, Nevada, United States
  • Urology Specialists of Nevada - Southwest — Las Vegas, Nevada, United States
  • Radiation Oncology Centers of Nevada Southeast — Las Vegas, Nevada, United States
  • Ann M Wierman MD LTD — Las Vegas, Nevada, United States
  • Comprehensive Cancer Centers of Nevada - Northwest — Las Vegas, Nevada, United States
  • GenesisCare USA - Vegas Tenaya — Las Vegas, Nevada, United States
  • Las Vegas Urology - Cathedral Rock — Las Vegas, Nevada, United States
  • Las Vegas Urology - Smoke Ranch — Las Vegas, Nevada, United States
  • OptumCare Cancer Care at MountainView — Las Vegas, Nevada, United States
  • Urology Specialists of Nevada - Northwest — Las Vegas, Nevada, United States
  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation — Las Vegas, Nevada, United States
  • Comprehensive Cancer Centers of Nevada - Town Center — Las Vegas, Nevada, United States
  • Comprehensive Cancer Centers of Nevada-Summerlin — Las Vegas, Nevada, United States
  • Summerlin Hospital Medical Center — Las Vegas, Nevada, United States
  • Las Vegas Cancer Center-Medical Center — Las Vegas, Nevada, United States
  • Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
  • GenesisCare USA - Fort Apache — Las Vegas, Nevada, United States
  • OptumCare Cancer Care at Fort Apache — Las Vegas, Nevada, United States
  • Comprehensive Cancer Centers of Nevada - Central Valley — Las Vegas, Nevada, United States
  • University Cancer Center — Las Vegas, Nevada, United States
  • Hope Cancer Care of Nevada-Pahrump — Pahrump, Nevada, United States
  • Renown Regional Medical Center — Reno, Nevada, United States
  • Saint Mary's Regional Medical Center — Reno, Nevada, United States
  • Radiation Oncology Associates — Reno, Nevada, United States
  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center — Lebanon, New Hampshire, United States
  • Hackensack University Medical Center — Hackensack, New Jersey, United States
  • University of New Mexico Cancer Center — Albuquerque, New Mexico, United States
  • Roswell Park Cancer Institute — Buffalo, New York, United States
  • Northwell Health/Center for Advanced Medicine — Lake Success, New York, United States
  • University of Rochester — Rochester, New York, United States
  • Phelps Memorial Hospital Center — Sleepy Hollow, New York, United States
  • Southeastern Medical Oncology Center-Clinton — Clinton, North Carolina, United States
  • Southeastern Medical Oncology Center-Goldsboro — Goldsboro, North Carolina, United States
  • Southeastern Medical Oncology Center-Jacksonville — Jacksonville, North Carolina, United States
  • UH Seidman Cancer Center at UH Avon Health Center — Avon, Ohio, United States
  • UHHS-Chagrin Highlands Medical Center — Beachwood, Ohio, United States
  • Indu and Raj Soin Medical Center — Beavercreek, Ohio, United States
  • Saint Elizabeth Boardman Hospital — Boardman, Ohio, United States
  • Dayton Physicians LLC-Miami Valley South — Centerville, Ohio, United States
  • Miami Valley Hospital South — Centerville, Ohio, United States
  • University of Cincinnati Cancer Center-UC Medical Center — Cincinnati, Ohio, United States
  • Oncology Hematology Care Inc-Kenwood — Cincinnati, Ohio, United States
  • Case Western Reserve University — Cleveland, Ohio, United States
  • Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
  • Miami Valley Hospital — Dayton, Ohio, United States
  • Dayton Physician LLC-Miami Valley Hospital North — Dayton, Ohio, United States
  • Miami Valley Hospital North — Dayton, Ohio, United States
  • Armes Family Cancer Center — Findlay, Ohio, United States
  • Blanchard Valley Hospital — Findlay, Ohio, United States
  • Orion Cancer Care — Findlay, Ohio, United States
  • Atrium Medical Center-Middletown Regional Hospital — Franklin, Ohio, United States
  • Dayton Physicians LLC-Atrium — Franklin, Ohio, United States
  • Dayton Physicians LLC-Wayne — Greenville, Ohio, United States
  • Wayne Hospital — Greenville, Ohio, United States
  • Greater Dayton Cancer Center — Kettering, Ohio, United States
  • Kettering Medical Center — Kettering, Ohio, United States
  • UH Seidman Cancer Center at Lake Health Mentor Campus — Mentor, Ohio, United States
  • Springfield Regional Cancer Center — Springfield, Ohio, United States
  • Springfield Regional Medical Center — Springfield, Ohio, United States
  • University of Toledo — Toledo, Ohio, United States
  • Dayton Physicians LLC - Troy — Troy, Ohio, United States
  • Upper Valley Medical Center — Troy, Ohio, United States
  • Saint Joseph Warren Hospital — Warren, Ohio, United States
  • University of Cincinnati Cancer Center-West Chester — West Chester, Ohio, United States
  • Saint Elizabeth Youngstown Hospital — Youngstown, Ohio, United States
  • University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
  • Mercy Hospital Oklahoma City — Oklahoma City, Oklahoma, United States
  • Kaiser Sunnyside Medical Center — Clackamas, Oregon, United States
  • Rogue Valley Medical Center — Medford, Oregon, United States
  • Kaiser Permanente Northwest — Portland, Oregon, United States
  • Oregon Health and Science University — Portland, Oregon, United States
  • UPMC Altoona — Altoona, Pennsylvania, United States
  • UPMC-Heritage Valley Health System Beaver — Beaver, Pennsylvania, United States
  • UPMC Hillman Cancer Center at Butler Health System — Butler, Pennsylvania, United States
  • UPMC Hillman Cancer Center Erie — Erie, Pennsylvania, United States
  • UPMC Cancer Center at UPMC Horizon — Farrell, Pennsylvania, United States
  • UPMC Cancer Centers - Arnold Palmer Pavilion — Greensburg, Pennsylvania, United States
  • IRMC Cancer Center — Indiana, Pennsylvania, United States
  • UPMC-Johnstown/John P. Murtha Regional Cancer Center — Johnstown, Pennsylvania, United States
  • UPMC Cancer Center at UPMC McKeesport — McKeesport, Pennsylvania, United States
  • UPMC Hillman Cancer Center - Monroeville — Monroeville, Pennsylvania, United States
  • UPMC Hillman Cancer Center - Part of Frick Hospital — Mount Pleasant, Pennsylvania, United States
  • Arnold Palmer Cancer Center Medical Oncology Norwin — N. Huntingdon, Pennsylvania, United States
  • UPMC Cancer Center-Natrona Heights — Natrona Heights, Pennsylvania, United States
  • UPMC Hillman Cancer Center - New Castle — New Castle, Pennsylvania, United States
  • UPMC-Saint Margaret — Pittsburgh, Pennsylvania, United States
  • University of Pittsburgh Cancer Institute (UPCI) — Pittsburgh, Pennsylvania, United States
  • UPMC-Shadyside Hospital — Pittsburgh, Pennsylvania, United States
  • UPMC-Passavant Hospital — Pittsburgh, Pennsylvania, United States
  • UPMC-Saint Clair Hospital Cancer Center — Pittsburgh, Pennsylvania, United States
  • UPMC Cancer Center at UPMC Northwest — Seneca, Pennsylvania, United States
  • UPMC Cancer Center-Uniontown — Uniontown, Pennsylvania, United States
  • UPMC Cancer Center-Washington — Washington, Pennsylvania, United States
  • UPMC West Mifflin-Cancer Center Jefferson — West Mifflin, Pennsylvania, United States
  • Prisma Health Cancer Institute - Spartanburg — Boiling Springs, South Carolina, United States
  • Medical University of South Carolina — Charleston, South Carolina, United States
  • Prisma Health Cancer Institute - Easley — Easley, South Carolina, United States
  • Prisma Health Cancer Institute - Butternut — Greenville, South Carolina, United States
  • Prisma Health Cancer Institute - Faris — Greenville, South Carolina, United States
  • Prisma Health Greenville Memorial Hospital — Greenville, South Carolina, United States
  • Prisma Health Cancer Institute - Eastside — Greenville, South Carolina, United States
  • Prisma Health Cancer Institute - Greer — Greer, South Carolina, United States
  • Prisma Health Cancer Institute - Seneca — Seneca, South Carolina, United States
  • UT Southwestern Simmons Cancer Center - RedBird — Dallas, Texas, United States
  • UT Southwestern/Simmons Cancer Center-Dallas — Dallas, Texas, United States
  • UT Southwestern/Simmons Cancer Center-Fort Worth — Fort Worth, Texas, United States
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center — Houston, Texas, United States
  • Ben Taub General Hospital — Houston, Texas, United States
  • UT Southwestern Clinical Center at Richardson/Plano — Richardson, Texas, United States
  • University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
  • University of Utah Sugarhouse Health Center — Salt Lake City, Utah, United States
  • Huntsman Cancer Institute/University of Utah — Salt Lake City, Utah, United States
  • George E Wahlen Department of Veterans Affairs Medical Center — Salt Lake City, Utah, United States
  • Norris Cotton Cancer Center-North — Saint Johnsbury, Vermont, United States
  • Overlake Medical Center — Bellevue, Washington, United States
  • Valley Medical Center — Renton, Washington, United States
  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital — Yakima, Washington, United States
  • Aurora Cancer Care-Southern Lakes VLCC — Burlington, Wisconsin, United States
  • Marshfield Clinic-Chippewa Center — Chippewa Falls, Wisconsin, United States
  • Marshfield Medical Center-EC Cancer Center — Eau Claire, Wisconsin, United States
  • Aurora Health Care Germantown Health Center — Germantown, Wisconsin, United States
  • Aurora Cancer Care-Grafton — Grafton, Wisconsin, United States
  • Aurora BayCare Medical Center — Green Bay, Wisconsin, United States
  • Aurora Cancer Care-Kenosha South — Kenosha, Wisconsin, United States
  • Marshfield Clinic - Ladysmith Center — Ladysmith, Wisconsin, United States
  • Aurora Bay Area Medical Group-Marinette — Marinette, Wisconsin, United States
  • Marshfield Medical Center-Marshfield — Marshfield, Wisconsin, United States
  • Froedtert Menomonee Falls Hospital — Menomonee Falls, Wisconsin, United States
  • Aurora Cancer Care-Milwaukee — Milwaukee, Wisconsin, United States
  • Aurora Saint Luke's Medical Center — Milwaukee, Wisconsin, United States
  • Medical College of Wisconsin — Milwaukee, Wisconsin, United States
  • Aurora Sinai Medical Center — Milwaukee, Wisconsin, United States
  • Marshfield Clinic-Minocqua Center — Minocqua, Wisconsin, United States
  • Cancer Center of Western Wisconsin — New Richmond, Wisconsin, United States
  • Drexel Town Square Health Center — Oak Creek, Wisconsin, United States
  • Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin, United States
  • Aurora Cancer Care-Racine — Racine, Wisconsin, United States
  • Marshfield Medical Center-Rice Lake — Rice Lake, Wisconsin, United States
  • Vince Lombardi Cancer Clinic-Sheboygan — Sheboygan, Wisconsin, United States
  • Marshfield Medical Center-River Region at Stevens Point — Stevens Point, Wisconsin, United States
  • Aurora Medical Center in Summit — Summit, Wisconsin, United States
  • Vince Lombardi Cancer Clinic-Two Rivers — Two Rivers, Wisconsin, United States
  • Marshfield Clinic-Wausau Center — Wausau, Wisconsin, United States
  • Aurora Cancer Care-Milwaukee West — Wauwatosa, Wisconsin, United States
  • Aurora West Allis Medical Center — West Allis, Wisconsin, United States
  • Froedtert West Bend Hospital/Kraemer Cancer Center — West Bend, Wisconsin, United States
  • Marshfield Medical Center - Weston — Weston, Wisconsin, United States
  • Marshfield Clinic - Wisconsin Rapids Center — Wisconsin Rapids, Wisconsin, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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