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RECRUITING Phase 4 ClinicalTrials.gov

A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation

Sponsor: Christian Candrian • ClinicalTrials.gov ID: NCT04432012

Registry updated: 2026-09-11
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Description

We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols. We'll evaluate the outcome of patients with knee osteoarthritis who are undergoing Total Knee Arthroplasty to understand which of the three treatments give more benefits to the patient.

Interventions

  • Dexamethasone Sodium Phosphate 4 mg/ml intravenous (Drug)
    Perioperative intravenous injection of 3 ml of solution (9mg of dexamethasone)
  • Dexamethasone Sodium Phosphate 4 mg/ml intra-articular (Drug)
    Perioperative intra-articular injection of 3 ml of solution (9mg of dexamethasone)

Eligibility criteria

Inclusion Criteria: * Patients undergoing unilateral primary TKA at the Ospedale Regionale di Lugano. * Patients with a BMI \>18.5 and \<35. * Patients able to provide informed consent and follow all the study procedures as indicated by the protocol. * Informed Consent as documented by signature (Appendix Informed Consent Form). Exclusion Criteria: * Contraindications to steroids. * Revision TKA. * Active steroid therapy. * Women who are pregnant or breast feeding. * Presence of other clinically significant concomitant disease states (ASA IV). * Uncontrolled diabetes mellitus * Known or suspected non-compliance, drug or alcohol abuse. * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * Participation in another study with investigational drug within the 30 days preceding and during the present study. * Previous enrolment into the current study. * Enrolment of the investigator, his/her family members, employees and other dependent persons.

Conditions

Total Knee Replacement

Locations

  • Ospedale Regionale di Lugano Civico e Italiano — Lugano, Switzerland
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record