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RECRUITING Phase 3 ClinicalTrials.gov

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Sponsor: ECOG-ACRIN Cancer Research Group • ClinicalTrials.gov ID: NCT04423211

Registry updated: 2026-08-19
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Description

This phase III trial tests two questions by two separate comparisons of therapies. The first question is whether enhanced therapy (apalutamide in combination with abiraterone + prednisone) added to standard of care (prostate radiation therapy and short term androgen deprivation) is more effective compared to standard of care alone in patients with prostate cancer who experience biochemical recurrence (a rise in the blood level of prostate specific antigen \[PSA\] after surgical removal of the prostate cancer). A second question tests treatment in patients with biochemical recurrence who show prostate cancer spreading outside the pelvis (metastasis) by positron emission tomography (PET) imaging. In these patients, the benefit of adding metastasis-directed radiation to enhanced therapy (apalutamide in combination with abiraterone + prednisone) is tested. Diagnostic procedures, such as PET, may help doctors look for cancer that has spread to the pelvis. Androgens are hormones that may cause the growth of prostate cancer cells. Apalutamide may help fight prostate cancer by blocking the use of androgens by the tumor cells. Metastasis-directed targeted radiation therapy uses high energy rays to kill tumor cells and shrink tumors that have spread. This trial may help doctors determine if using PET results to deliver more tailored treatment (i.e., adding apalutamide, with or without targeted radiation therapy, to standard of care treatment) works better than standard of care treatment alone in patients with biochemical recurrence of prostate cancer.

Interventions

  • 3-Dimensional Conformal Radiation Therapy (Radiation)
    Undergo 3D CRT
  • Apalutamide (Drug)
    Given PO
  • Computed Tomography (Procedure)
    Undergo PET/CT
  • Degarelix (Drug)
    Given SC
  • External Beam Radiation Therapy (Radiation)
    Undergo EBRT
  • Fluciclovine F18 (Other)
    Given IV
  • Goserelin Acetate (Drug)
    Given SC
  • Intensity-Modulated Proton Therapy (Procedure)
    Undergo IMPT
  • Intensity-Modulated Radiation Therapy (Radiation)
    Undergo IMRT
  • Leuprolide Acetate (Drug)
    Given IM
  • Magnetic Resonance Imaging (Procedure)
    Undergo PET/MR
  • Positron Emission Tomography (Procedure)
    Undergo PET/CT or PET/MR
  • Quality-of-Life Assessment (Other)
    Ancillary studies
  • Questionnaire Administration (Other)
    Ancillary studies
  • Relugolix (Drug)
    Given PO
  • Stereotactic Body Radiation Therapy (Radiation)
    Undergo SBRT
  • Triptorelin (Drug)
    Given IM
  • Volume Modulated Arc Therapy (Radiation)
    Undergo VMAT

Eligibility criteria

Inclusion Criteria: * STEP 0: REGISTRATION ELIGIBILITY CRITERIA * Patient must be male and \>= 18 years of age. * Patient must have had a radical prostatectomy (RP) as definitive therapy for histopathologically-proven prostatic adenocarcinoma * Patient must have biochemical recurrence (BCR) after RP, defined as follows: * If time to BCR, defined as time to first detectable PSA ( \> lower limit of normal for assay used) after RP, is \< 12 months, a minimum PSA level of \>= 0.2 ng/mL and a confirmatory reading of \>= 0.2 ng/mL is required, per the American Urological Association (AUA) definition (Note: patients with a persistent PSA reading of at least 0.2 ng/mL are eligible) * If time to BCR, defined as time to first detectable PSA (\> lower limit of normal for assay used) after RP, is \>= 12 months, a minimum absolute PSA of 0.5 ng/mL is required * If the patient has a detectable PSA (\> lower limit of normal for assay used) at any time after RP AND has an eligible baseline SOC PET (PET1) with at least one positive lesion in any location, then there is no minimum PSA requirement * Patients must have no definite evidence for extrapelvic metastatic disease by conventional imaging modalities (CIM) (CT abdomen/pelvis or MRI abdomen/pelvis AND bone scintigraphy, or equivalent), within 26 weeks prior to Step 0 registration. If a patient only has a study-eligible PET/CT or PET/MR (i.e., PET done without prior CIM): if the PET is negative for extrapelvic lesions, then baseline CIM is NOT required. If the PET positive for extrapelvic lesions, then patient should have a baseline CT/MRI for soft tissue lesions and/or a bone scan for osseous lesions * Study eligible = PET using FDA-approved radiotracer and performed within 16 weeks prior to study registration * Extra-pelvic metastases is defined as any osseous metastases and/or any extrapelvic soft tissue, lymph nodes and organ metastases; extra-pelvic is defined as superior to common iliac bifurcation, outside of standard prostate bed + whole pelvis nodal RT fields. Baseline PET/CT or PET/MR scan (PET1) is eligible for this study if the SOC PET scan is completed with an FDA approved radiotracer for prostate cancer after Step 0 registration and prior to Step 1 randomization OR up to 16 weeks prior to Step 0 registration * Patient must be a candidate for SOC post-prostatectomy radiation therapy (RT) to the prostate bed and pelvic nodes with androgen deprivation therapy (ADT) * Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible * Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2 * Patient must not have started ADT for biochemical recurrence prior to baseline PET (PET1) imaging. A short course of low-dose anti-androgen such as bicalutamide, given after baseline study PET/CT but prior to study registration, is permitted as a brief temporizing measure in advance of starting protocol-approved SOC ADT. * Patient must not be enrolled in another therapeutic clinical trial * Patient must be able to lie flat and still for approximately 20-30 minutes or otherwise tolerate a PET scan and radiation treatment planning and delivery * Patients undergoing a PET/MR must meet local institutional safety guidelines for MRI * Patient must not have history of seizures or known condition that may cause predisposal to seizures (e.g., stroke or head trauma resulting in loss of consciousness) within 1 year prior to registration * Patient must not have history of inflammatory bowel disease or any gastrointestinal disorder affecting absorption that is expected to increase risk of complication from radiotherapy * Hemoglobin (Hgb) \>= 9.0 g/dL (independent of transfusion and/or growth factors within 3 months prior to Step 0 registration) (obtained within 8 weeks prior to Step 0 registration) * Leukocytes \>= 3,000/mcL (obtained within 8 weeks prior to Step 0 registration) * Absolute neutrophil count \>= 1,500/mcL (obtained within 8 weeks prior to Step 0 registration) * Platelets \>= 100,000/mcL (obtained within 8 weeks prior to Step 0 registration) * Total bilirubin \< 1.5 x institutional upper limit of normal (ULN) (patients with Gilbert's syndrome, if total bilirubin is \> 1.5 x ULN, must have a direct bilirubin of \< 1.5 x ULN to be eligible) (obtained within 8 weeks prior to Step 0 registration) * Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional ULN (obtained within 8 weeks prior to Step 0 registration) * Creatine \< 1.5 x instituional ULN (or measured creatinine clearance \> 30 mL/min) * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class I or II (by patient symptoms) or A or B (by objective assessment) * Patient must not have completed a course of prior pelvic radiation therapy for any reason * Patient must agree not to father children while on study * Patient must be English or Spanish speaking to be eligible for the QOL component of the study * NOTE: Sites cannot translate the associated QOL forms * STEP 1: RANDOMIZATION ELIGIBILITY CRITERIA * Patient must have completed a baseline SOC PET/CT or PET/MR (PET1 scan) using FDA approved radiotracer with results of extra-pelvic metastases involvement known (positive or negative). The PET1 must have been completed after Step 0 registration and prior to Step 1 randomization OR up to 12 weeks prior to Step 0 registration * For patients with negative extra-pelvic metastases, PET-imaging status of intra-pelvic nodes must be known (positive or negative) * For patients with positive extra-pelvic metastases (defined as any PET positive lesions outside of standard salvage RT fields \[prostate bed +/- typical whole pelvis\]), the number of extra-pelvic lesions must be known (1 - 5 or \> 5 extra-pelvic lesions)

Conditions

Biochemically Recurrent Prostate Carcinoma Metastatic Prostate Carcinoma Prostate Adenocarcinoma Stage IVB Prostate Cancer AJCC v8

Locations

  • Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
  • Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
  • Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
  • Alaska Women's Cancer Care — Anchorage, Alaska, United States
  • Anchorage Oncology Centre — Anchorage, Alaska, United States
  • Katmai Oncology Group — Anchorage, Alaska, United States
  • Providence Alaska Medical Center — Anchorage, Alaska, United States
  • Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
  • Cancer Center at Saint Joseph's — Phoenix, Arizona, United States
  • Mercy Hospital Fort Smith — Fort Smith, Arkansas, United States
  • Mission Hope Medical Oncology - Arroyo Grande — Arroyo Grande, California, United States
  • Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
  • Mercy Cancer Center - Carmichael — Carmichael, California, United States
  • Mercy San Juan Medical Center — Carmichael, California, United States
  • City of Hope Corona — Corona, California, United States
  • City of Hope Comprehensive Cancer Center — Duarte, California, United States
  • Mercy Cancer Center - Elk Grove — Elk Grove, California, United States
  • UC San Diego Health System - Encinitas — Encinitas, California, United States
  • UC San Diego Moores Cancer Center — La Jolla, California, United States
  • City of Hope Antelope Valley — Lancaster, California, United States
  • Los Angeles General Medical Center — Los Angeles, California, United States
  • USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
  • UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California, United States
  • Mercy Cancer Center — Merced, California, United States
  • VA Palo Alto Health Care System — Palo Alto, California, United States
  • Mercy Cancer Center - Rocklin — Rocklin, California, United States
  • Mercy Cancer Center - Sacramento — Sacramento, California, United States
  • UC San Diego Medical Center - Hillcrest — San Diego, California, United States
  • Pacific Central Coast Health Center-San Luis Obispo — San Luis Obispo, California, United States
  • Mission Hope Medical Oncology - Santa Maria — Santa Maria, California, United States
  • City of Hope South Pasadena — South Pasadena, California, United States
  • Saint Joseph's Medical Center — Stockton, California, United States
  • City of Hope Upland — Upland, California, United States
  • BASS Medical Group - Lennon — Walnut Creek, California, United States
  • Woodland Memorial Hospital — Woodland, California, United States
  • Rocky Mountain Cancer Centers-Aurora — Aurora, Colorado, United States
  • Rocky Mountain Cancer Centers-Boulder — Boulder, Colorado, United States
  • Penrose-Saint Francis Healthcare — Colorado Springs, Colorado, United States
  • Rocky Mountain Cancer Centers-Penrose — Colorado Springs, Colorado, United States
  • Saint Francis Cancer Center — Colorado Springs, Colorado, United States
  • AdventHealth Porter — Denver, Colorado, United States
  • Presbyterian - Saint Lukes Medical Center - Health One — Denver, Colorado, United States
  • Dillon Health Center/Shaw Cancer Center — Dillon, Colorado, United States
  • Shaw Cancer Center — Edwards, Colorado, United States
  • The Melanoma and Skin Cancer Institute — Englewood, Colorado, United States
  • CommonSpirit Saint Anthony Hospital Cancer Center — Lakewood, Colorado, United States
  • Rocky Mountain Cancer Centers-Littleton — Littleton, Colorado, United States
  • AdventHealth Littleton — Littleton, Colorado, United States
  • Longmont United Hospital — Longmont, Colorado, United States
  • AdventHealth Parker — Parker, Colorado, United States
  • Saint Mary Corwin Medical Center — Pueblo, Colorado, United States
  • Rocky Mountain Cancer Centers-Thornton — Thornton, Colorado, United States
  • Saint Anthony North Hospital — Westminster, Colorado, United States
  • Sibley Memorial Hospital — Washington D.C., District of Columbia, United States
  • Moffitt Cancer Center-International Plaza — Tampa, Florida, United States
  • Moffitt Cancer Center - McKinley Campus — Tampa, Florida, United States
  • Moffitt Cancer Center — Tampa, Florida, United States
  • Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida, United States
  • Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho, United States
  • Saint Luke's Cancer Institute - Boise — Boise, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
  • Kootenai Health - Coeur d'Alene — Coeur d'Alene, Idaho, United States
  • Saint Luke's Cancer Institute - Fruitland — Fruitland, Idaho, United States
  • Idaho Urologic Institute-Meridian — Meridian, Idaho, United States
  • Saint Luke's Cancer Institute - Meridian — Meridian, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Nampa — Nampa, Idaho, United States
  • Saint Luke's Cancer Institute - Nampa — Nampa, Idaho, United States
  • Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
  • Saint Luke's Cancer Institute - Twin Falls — Twin Falls, Idaho, United States
  • Alton Memorial Hospital — Alton, Illinois, United States
  • OSF Saint Anthony's Health Center — Alton, Illinois, United States
  • Rush-Copley Medical Center — Aurora, Illinois, United States
  • Illinois CancerCare-Bloomington — Bloomington, Illinois, United States
  • Illinois CancerCare-Canton — Canton, Illinois, United States
  • Memorial Hospital of Carbondale — Carbondale, Illinois, United States
  • SIH Cancer Institute — Carterville, Illinois, United States
  • Illinois CancerCare-Carthage — Carthage, Illinois, United States
  • Centralia Oncology Clinic — Centralia, Illinois, United States
  • Saint Mary's Hospital — Centralia, Illinois, United States
  • Northwestern University — Chicago, Illinois, United States
  • Rush MD Anderson Cancer Center — Chicago, Illinois, United States
  • University of Illinois — Chicago, Illinois, United States
  • Carle at The Riverfront — Danville, Illinois, United States
  • Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois, United States
  • Decatur Memorial Hospital — Decatur, Illinois, United States
  • Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois, United States
  • Illinois CancerCare-Dixon — Dixon, Illinois, United States
  • Carle Physician Group-Effingham — Effingham, Illinois, United States
  • Crossroads Cancer Center — Effingham, Illinois, United States
  • Illinois CancerCare-Eureka — Eureka, Illinois, United States
  • Illinois CancerCare-Galesburg — Galesburg, Illinois, United States
  • Western Illinois Cancer Treatment Center — Galesburg, Illinois, United States
  • Northwestern Medicine Cancer Center Delnor — Geneva, Illinois, United States
  • Illinois CancerCare-Kewanee Clinic — Kewanee, Illinois, United States
  • Rush MD Anderson Cancer Center at Rush Lisle — Lisle, Illinois, United States
  • Illinois CancerCare-Macomb — Macomb, Illinois, United States
  • Carle Physician Group-Mattoon/Charleston — Mattoon, Illinois, United States
  • Loyola University Medical Center — Maywood, Illinois, United States
  • SSM Health Good Samaritan — Mount Vernon, Illinois, United States
  • Cancer Care Center of O'Fallon — O'Fallon, Illinois, United States
  • HSHS Saint Elizabeth's Hospital — O'Fallon, Illinois, United States
  • Northwestern Medicine Oak Brook — Oak Brook, Illinois, United States
  • Rush MD Anderson Cancer Center at Rush Oak Park — Oak Park, Illinois, United States
  • Northwestern Medicine Orland Park — Orland Park, Illinois, United States
  • Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois, United States
  • Illinois CancerCare-Pekin — Pekin, Illinois, United States
  • Illinois CancerCare-Peoria — Peoria, Illinois, United States
  • Methodist Medical Center of Illinois — Peoria, Illinois, United States
  • Illinois CancerCare-Peru — Peru, Illinois, United States
  • Valley Radiation Oncology — Peru, Illinois, United States
  • Illinois CancerCare-Princeton — Princeton, Illinois, United States
  • UW Health Carbone Cancer Center Rockford — Rockford, Illinois, United States
  • Southern Illinois University School of Medicine — Springfield, Illinois, United States
  • Springfield Clinic — Springfield, Illinois, United States
  • Springfield Memorial Hospital — Springfield, Illinois, United States
  • Carle Cancer Center — Urbana, Illinois, United States
  • The Carle Foundation Hospital — Urbana, Illinois, United States
  • Northwestern Medicine Cancer Center Warrenville — Warrenville, Illinois, United States
  • Illinois CancerCare - Washington — Washington, Illinois, United States
  • Mercy Hospital — Cedar Rapids, Iowa, United States
  • Oncology Associates at Mercy Medical Center — Cedar Rapids, Iowa, United States
  • Central Care Cancer Center - Garden City — Garden City, Kansas, United States
  • Central Care Cancer Center - Great Bend — Great Bend, Kansas, United States
  • Mercy Hospital Pittsburg — Pittsburg, Kansas, United States
  • CommonSpirit Saint Joseph Hospital - Lexington — Lexington, Kentucky, United States
  • Saint Joseph Radiation Oncology Resource Center — Lexington, Kentucky, United States
  • CommonSpirit Saint Joseph Medical Center - East Lexington — Lexington, Kentucky, United States
  • Jewish Hospital — Louisville, Kentucky, United States
  • LSU Health Baton Rouge-North Clinic — Baton Rouge, Louisiana, United States
  • Our Lady of the Lake Physician Group — Baton Rouge, Louisiana, United States
  • MaineHealth Coastal Cancer Treatment Center — Bath, Maine, United States
  • MaineHealth Maine Medical Center - Biddeford — Biddeford, Maine, United States
  • MaineHealth Maine Medical Center - Portland — Portland, Maine, United States
  • MaineHealth Cancer Care and IV Therapy - Sanford — Sanford, Maine, United States
  • MaineHealth Cancer Care Center of York County — Sanford, Maine, United States
  • MaineHealth Maine Medical Center- Scarborough — Scarborough, Maine, United States
  • MaineHealth Cancer Care and IV Therapy - South Portland — South Portland, Maine, United States
  • University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland, United States
  • Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore, Maryland, United States
  • Suburban Hospital — Bethesda, Maryland, United States
  • UM Baltimore Washington Medical Center/Tate Cancer Center — Glen Burnie, Maryland, United States
  • Minnesota Oncology - Burnsville — Burnsville, Minnesota, United States
  • Minnesota Oncology Hematology PA-Chaska — Chaska, Minnesota, United States
  • Mercy Hospital — Coon Rapids, Minnesota, United States
  • Minnesota Oncology - Coon Rapids — Coon Rapids, Minnesota, United States
  • Fairview Southdale Hospital — Edina, Minnesota, United States
  • Minnesota Oncology - Edina — Edina, Minnesota, United States
  • Unity Hospital — Fridley, Minnesota, United States
  • Fairview Clinics and Surgery Center Maple Grove — Maple Grove, Minnesota, United States
  • Minnesota Oncology - Maple Grove — Maple Grove, Minnesota, United States
  • Minnesota Oncology Hematology PA-Maplewood — Maplewood, Minnesota, United States
  • Saint John's Hospital - Healtheast — Maplewood, Minnesota, United States
  • Abbott-Northwestern Hospital — Minneapolis, Minnesota, United States
  • Hennepin County Medical Center — Minneapolis, Minnesota, United States
  • Health Partners Inc — Minneapolis, Minnesota, United States
  • Monticello Cancer Center — Monticello, Minnesota, United States
  • North Memorial Medical Health Center — Robbinsdale, Minnesota, United States
  • Coborn Cancer Center at Saint Cloud Hospital — Saint Cloud, Minnesota, United States
  • Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
  • Regions Hospital — Saint Paul, Minnesota, United States
  • United Hospital — Saint Paul, Minnesota, United States
  • Saint Francis Regional Medical Center — Shakopee, Minnesota, United States
  • Lakeview Hospital — Stillwater, Minnesota, United States
  • Ridgeview Medical Center — Waconia, Minnesota, United States
  • Rice Memorial Hospital — Willmar, Minnesota, United States
  • Minnesota Oncology Hematology PA-Woodbury — Woodbury, Minnesota, United States
  • Baptist Cancer Center-Grenada — Grenada, Mississippi, United States
  • University of Mississippi Medical Center — Jackson, Mississippi, United States
  • Baptist Memorial Hospital and Cancer Center-Union County — New Albany, Mississippi, United States
  • Baptist Memorial Hospital and Cancer Center-Oxford — Oxford, Mississippi, United States
  • Central Care Cancer Center - Bolivar — Bolivar, Missouri, United States
  • Mercy Cancer Center - Cape Girardeau — Cape Girardeau, Missouri, United States
  • Saint Francis Medical Center — Cape Girardeau, Missouri, United States
  • Siteman Cancer Center at Saint Peters Hospital — City of Saint Peters, Missouri, United States
  • Siteman Cancer Center at West County Hospital — Creve Coeur, Missouri, United States
  • Parkland Health Center - Farmington — Farmington, Missouri, United States
  • MU Health Care Goldschmidt Cancer Center — Jefferson City, Missouri, United States
  • Freeman Health System — Joplin, Missouri, United States
  • Mercy Hospital Joplin — Joplin, Missouri, United States
  • Lake Regional Hospital — Osage Beach, Missouri, United States
  • Mercy Clinic-Rolla-Cancer and Hematology — Rolla, Missouri, United States
  • Phelps Health Delbert Day Cancer Institute — Rolla, Missouri, United States
  • Heartland Regional Medical Center — Saint Joseph, Missouri, United States
  • Sainte Genevieve County Memorial Hospital — Sainte Genevieve, Missouri, United States
  • Mercy Hospital Springfield — Springfield, Missouri, United States
  • CoxHealth South Hospital — Springfield, Missouri, United States
  • Washington University School of Medicine — St Louis, Missouri, United States
  • Mercy Hospital South — St Louis, Missouri, United States
  • Siteman Cancer Center-South County — St Louis, Missouri, United States
  • Missouri Baptist Medical Center — St Louis, Missouri, United States
  • Siteman Cancer Center at Christian Hospital — St Louis, Missouri, United States
  • Mercy Hospital Saint Louis — St Louis, Missouri, United States
  • Missouri Baptist Sullivan Hospital — Sullivan, Missouri, United States
  • Billings Clinic Cancer Center — Billings, Montana, United States
  • Bozeman Health Deaconess Hospital — Bozeman, Montana, United States
  • Benefis Sletten Cancer Institute — Great Falls, Montana, United States
  • Great Falls Clinic — Great Falls, Montana, United States
  • Hi-Line Sletten Cancer Center — Havre, Montana, United States
  • Logan Health Medical Center — Kalispell, Montana, United States
  • Saint Patrick Hospital - Community Hospital — Missoula, Montana, United States
  • Community Medical Center — Missoula, Montana, United States
  • CHI Health Good Samaritan — Kearney, Nebraska, United States
  • Alegent Health Immanuel Medical Center — Omaha, Nebraska, United States
  • Alegent Health Bergan Mercy Medical Center — Omaha, Nebraska, United States
  • Alegent Health Lakeside Hospital — Omaha, Nebraska, United States
  • Cooper Hospital University Medical Center — Camden, New Jersey, United States
  • Hackensack University Medical Center — Hackensack, New Jersey, United States
  • Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
  • Robert Wood Johnson University Hospital Somerset — Somerville, New Jersey, United States
  • Community Medical Center — Toms River, New Jersey, United States
  • MD Anderson Cancer Center at Cooper-Voorhees — Voorhees Township, New Jersey, United States
  • Northwell Health Imbert Cancer Center — Bay Shore, New York, United States
  • Northwell Health Physicians Partners Radiation Medicine at Queens — Forest Hills, New York, United States
  • Northwell Health/Center for Advanced Medicine — Lake Success, New York, United States
  • Mount Sinai Union Square — New York, New York, United States
  • Mount Sinai Chelsea — New York, New York, United States
  • Mount Sinai West — New York, New York, United States
  • Mount Sinai Hospital — New York, New York, United States
  • New York Proton Center — New York, New York, United States
  • Manhattan Eye Ear and Throat Hospital — New York, New York, United States
  • Lenox Hill Hospital — New York, New York, United States
  • Queens Cancer Center — Rego Park, New York, United States
  • Phelps Memorial Hospital Center — Sleepy Hollow, New York, United States
  • Stony Brook University Medical Center — Stony Brook, New York, United States
  • Montefiore Medical Center-Einstein Campus — The Bronx, New York, United States
  • Montefiore Medical Center-Weiler Hospital — The Bronx, New York, United States
  • Montefiore Medical Center - Moses Campus — The Bronx, New York, United States
  • Westchester Medical Center — Valhalla, New York, United States
  • ECU Health Oncology Kenansville — Kenansville, North Carolina, United States
  • ECU Health Oncology Kinston — Kinston, North Carolina, United States
  • ECU Health Oncology Richlands — Richlands, North Carolina, United States
  • University of Cincinnati Cancer Center-UC Medical Center — Cincinnati, Ohio, United States
  • Good Samaritan Hospital - Cincinnati — Cincinnati, Ohio, United States
  • Bethesda North Hospital — Cincinnati, Ohio, United States
  • Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
  • University of Cincinnati Cancer Center-West Chester — West Chester, Ohio, United States
  • University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
  • Mercy Hospital Oklahoma City — Oklahoma City, Oklahoma, United States
  • Saint Charles Health System — Bend, Oregon, United States
  • Clackamas Radiation Oncology Center — Clackamas, Oregon, United States
  • Providence Cancer Institute Clackamas Clinic — Clackamas, Oregon, United States
  • Bay Area Hospital — Coos Bay, Oregon, United States
  • Legacy Mount Hood Medical Center — Gresham, Oregon, United States
  • Providence Newberg Medical Center — Newberg, Oregon, United States
  • Providence Willamette Falls Medical Center — Oregon City, Oregon, United States
  • Legacy Good Samaritan Hospital and Medical Center — Portland, Oregon, United States
  • Providence Portland Medical Center — Portland, Oregon, United States
  • Providence Saint Vincent Medical Center — Portland, Oregon, United States
  • Oregon Health and Science University — Portland, Oregon, United States
  • Legacy Meridian Park Hospital — Tualatin, Oregon, United States
  • UPMC Altoona — Altoona, Pennsylvania, United States
  • UPMC-Heritage Valley Health System Beaver — Beaver, Pennsylvania, United States
  • Crozer-Keystone Regional Cancer Center at Broomall — Broomall, Pennsylvania, United States
  • Carlisle Regional Cancer Center — Carlisle, Pennsylvania, United States
  • Delaware County Memorial Hospital — Drexel Hill, Pennsylvania, United States
  • Fox Chase Cancer Center - East Norriton Hospital Outpatient Center — East Norriton, Pennsylvania, United States
  • UPMC Hillman Cancer Center Erie — Erie, Pennsylvania, United States
  • UPMC Cancer Center at UPMC Horizon — Farrell, Pennsylvania, United States
  • Fox Chase Cancer Center Buckingham — Furlong, Pennsylvania, United States
  • Crozer Regional Cancer Center at Brinton Lake — Glen Mills, Pennsylvania, United States
  • UPMC Cancer Centers - Arnold Palmer Pavilion — Greensburg, Pennsylvania, United States
  • UPMC Pinnacle Cancer Center/Community Osteopathic Campus — Harrisburg, Pennsylvania, United States
  • Penn State Milton S Hershey Medical Center — Hershey, Pennsylvania, United States
  • UPMC-Johnstown/John P. Murtha Regional Cancer Center — Johnstown, Pennsylvania, United States
  • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion — Mechanicsburg, Pennsylvania, United States
  • UPMC Cancer Center - Monroeville — Monroeville, Pennsylvania, United States
  • UPMC Hillman Cancer Center in Coraopolis — Moon Township, Pennsylvania, United States
  • UPMC Cancer Center-Natrona Heights — Natrona Heights, Pennsylvania, United States
  • UPMC Hillman Cancer Center - New Castle — New Castle, Pennsylvania, United States
  • Penn Presbyterian Medical Center — Philadelphia, Pennsylvania, United States
  • University of Pennsylvania/Abramson Cancer Center — Philadelphia, Pennsylvania, United States
  • Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States
  • Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
  • Temple University Hospital — Philadelphia, Pennsylvania, United States
  • UPMC-Magee Womens Hospital — Pittsburgh, Pennsylvania, United States
  • UPMC-Saint Margaret — Pittsburgh, Pennsylvania, United States
  • UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
  • UPMC-Shadyside Hospital — Pittsburgh, Pennsylvania, United States
  • UPMC-Passavant Hospital — Pittsburgh, Pennsylvania, United States
  • UPMC-Saint Clair Hospital Cancer Center — Pittsburgh, Pennsylvania, United States
  • UPMC Cancer Center at UPMC Northwest — Seneca, Pennsylvania, United States
  • UPMC Cancer Center-Uniontown — Uniontown, Pennsylvania, United States
  • UPMC Uniontown Hospital Radiation Oncology — Uniontown, Pennsylvania, United States
  • UPMC Washington Hospital Radiation Oncology — Washington, Pennsylvania, United States
  • UPMC Susquehanna — Williamsport, Pennsylvania, United States
  • UPMC Memorial — York, Pennsylvania, United States
  • Medical University of South Carolina — Charleston, South Carolina, United States
  • Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota, United States
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota, United States
  • Parkland Memorial Hospital — Dallas, Texas, United States
  • UT Southwestern Simmons Cancer Center - RedBird — Dallas, Texas, United States
  • UT Southwestern/Simmons Cancer Center-Dallas — Dallas, Texas, United States
  • Tarrant County Hospital District/JPS Health Network — Fort Worth, Texas, United States
  • UT Southwestern/Simmons Cancer Center-Fort Worth — Fort Worth, Texas, United States
  • UT Southwestern Clinical Center at Richardson/Plano — Richardson, Texas, United States
  • Audie L Murphy VA Hospital — San Antonio, Texas, United States
  • University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
  • University of Virginia Cancer Center — Charlottesville, Virginia, United States
  • VCU Massey Comprehensive Cancer Center — Richmond, Virginia, United States
  • Providence Regional Cancer System-Aberdeen — Aberdeen, Washington, United States
  • PeaceHealth Saint Joseph Medical Center — Bellingham, Washington, United States
  • Providence Regional Cancer System-Centralia — Centralia, Washington, United States
  • Swedish Cancer Institute-Edmonds — Edmonds, Washington, United States
  • Providence Regional Cancer Partnership — Everett, Washington, United States
  • Swedish Cancer Institute-Issaquah — Issaquah, Washington, United States
  • Kadlec Clinic Hematology and Oncology — Kennewick, Washington, United States
  • Providence Regional Cancer System-Lacey — Lacey, Washington, United States
  • PeaceHealth Saint John Medical Center — Longview, Washington, United States
  • Skagit Regional Health Cancer Care Center — Mount Vernon, Washington, United States
  • Swedish Medical Center-Ballard Campus — Seattle, Washington, United States
  • Fred Hutchinson Cancer Center — Seattle, Washington, United States
  • Swedish Medical Center-Cherry Hill — Seattle, Washington, United States
  • Swedish Medical Center-First Hill — Seattle, Washington, United States
  • FHCC at Northwest Hospital — Seattle, Washington, United States
  • University of Washington Medical Center - Montlake — Seattle, Washington, United States
  • PeaceHealth United General Medical Center — Sedro-Woolley, Washington, United States
  • Saint Joseph Medical Center Hematology and Oncology - Silverdale — Silverdale, Washington, United States
  • Cancer Care Northwest - Spokane South — Spokane, Washington, United States
  • Cancer Care Northwest-North Spokane — Spokane, Washington, United States
  • PeaceHealth Southwest Medical Center — Vancouver, Washington, United States
  • Legacy Cancer Institute Medical Oncology and Day Treatment — Vancouver, Washington, United States
  • Legacy Salmon Creek Hospital — Vancouver, Washington, United States
  • Providence Saint Mary Regional Cancer Center — Walla Walla, Washington, United States
  • Aspirus Cancer Care-Antigo-Volm Cancer Center — Antigo, Wisconsin, United States
  • Marshfield Medical Center-EC Cancer Center — Eau Claire, Wisconsin, United States
  • University of Wisconsin Carbone Cancer Center - Johnson Creek — Johnson Creek, Wisconsin, United States
  • William S Middleton VA Medical Center — Madison, Wisconsin, United States
  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center — Madison, Wisconsin, United States
  • University of Wisconsin Carbone Cancer Center - University Hospital — Madison, Wisconsin, United States
  • Marshfield Medical Center-Marshfield — Marshfield, Wisconsin, United States
  • Marshfield Medical Center - Minocqua — Minocqua, Wisconsin, United States
  • Cancer Center of Western Wisconsin — New Richmond, Wisconsin, United States
  • Aspirus Cancer Care-Rhinelander-James Beck Cancer Center — Rhinelander, Wisconsin, United States
  • Marshfield Medical Center-Rice Lake — Rice Lake, Wisconsin, United States
  • Aspirus Cancer Care - Stevens Point — Stevens Point, Wisconsin, United States
  • Marshfield Medical Center-River Region at Stevens Point — Stevens Point, Wisconsin, United States
  • Aspirus Cancer Care-Wausau — Wausau, Wisconsin, United States
  • Marshfield Medical Center - Weston — Weston, Wisconsin, United States
  • Aspirus Cancer Care - Wisconsin Rapids — Wisconsin Rapids, Wisconsin, United States
  • Memorial Hospital of Laramie County — Cheyenne, Wyoming, United States
  • Welch Cancer Center — Sheridan, Wyoming, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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