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RECRUITING Not applicable ClinicalTrials.gov

Thrombus Aspiration in STEMI Patients With High Thrombus Burden

Sponsor: Guangdong Provincial People's Hospital • ClinicalTrials.gov ID: NCT04212494

Registry updated: 2026-09-09
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Description

This is a prospective, multicenter, open-label, randomized, controlled, parallel group study, in which ST-segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(TIMI thrombus grade ≥3) are included. Patients are randomized to be treated with or without manual thrombus aspiration(TA) during primary percutaneous coronary intervention(PPCI) by a ratio of 1:1.

Interventions

  • Thrombus aspiration (Procedure)
    Percutaneous Coronary Intervention with manual aspiration thrombectomy
  • PCI Alone (Procedure)
    Percutaneous Coronary Intervention without manual aspiration thrombectomy

Eligibility criteria

Inclusion Criteria: 1. Age ≥ 18 years; 2. STEMI patients undergoing primary PCI within 12 hours after the onset of symptoms; 3. High thrombus burden after guidewire passes the lesion (TIMI thrombus grade ≥3); 4. Informed consent must be voluntary; Exclusion Criteria: 1. Haemodynamic instability or cardiogenic shock; 2. After thrombolytic therapy; 3. The predicted survival time is less than 6 months due to non-cardiac disease; 4. History of coronary artery bypass grafting; 5. Participate in other researches within 30 days; 6. Preoperative gastrointestinal bleeding or contraindications to dual antiplatelet therapy; 7. Patients were considered unsuitable by other researchers.

Conditions

ST-segment Elevation Myocardial Infarction (STEMI)

Locations

  • Fujian Provincial Hospital — Fuzhou, Fujian, China
  • First People's Hospital of Foshan — Foshan, Guangdong, China
  • The Second People's Hospital of Nanhai District — Foshan, Guangdong, China
  • First People's Hospital of Shunde (Affiliated Hospital at Shunde, Southern Medical University) — Foshan, Guangdong, China
  • Guangdong Provincial People's Hospital — Guangzhou, Guangdong, China
  • Guangzhou Panyu Central Hospital — Guangzhou, Guangdong, China
  • Guangzhou General Hospital of Guangzhou Military Command — Guangzhou, Guangdong, China
  • The first Affiliated Hospital, Sun Yat-Sen University — Guangzhou, Guangdong, China
  • Guangdong Provincial Hospital of traditional Chinese Medicine — Guangzhou, Guangdong, China
  • The First Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China
  • The Second Affiliated Hospital, Sun Yat-Sen University — Guangzhou, Guangdong, China
  • Zhujiang Hospital of Southern Medical University — Guangzhou, Guangdong, China
  • Nanfang Hospital — Guangzhou, Guangdong, China
  • Huangpu Division of The First Affiliated Hospital, Sun Yat-sen University — Guangzhou, Guangdong, China
  • Huadu District People's Hospital of Guangzhou — Guangzhou, Guangdong, China
  • Huizhou Third People's Hospital — Huizhou, Guangdong, China
  • Jiangmen Central Hospital — Jiangmen, Guangdong, China
  • Kaiping Central Hospital — Kaiping, Guangdong, China
  • Maoming People's Hospital — Maoming, Guangdong, China
  • The Second Affiliated Hospital of Shantou university Medical College — Shantou, Guangdong, China
  • Yue Bei People's Hospital — Shaoguan, Guangdong, China
  • Shenzhen People's Hospital — Shenzhen, Guangdong, China
  • The Eighth Affiliated Hospital, Sun Yat-Sen University — Shenzhen, Guangdong, China
  • Peking University Shenzhen Hospital — Shenzhen, Guangdong, China
  • Shenzhen Bao'an District People's Hospital — Shenzhen, Guangdong, China
  • Taishan people's Hospital — Taishan, Guangdong, China
  • Nanxiong people's Hospital — Xiongzhou, Guangdong, China
  • People's Hospital of Yangjiang City — Yangjiang, Guangdong, China
  • The Second Affiliated Hospital of Guangdong Medical University — Zhanjiang, Guangdong, China
  • Sihui people's Hospital — Zhaoqing, Guangdong, China
  • Zhongshan People's Hospital — Zhongshan, Guangdong, China
  • The Fifth Affiliated Hospital, Sun Yat-Sen University — Zhuhai, Guangdong, China
  • Zhuhai people's Hospital — Zhuhai, Guangdong, China
  • Guilin people's Hospital — Guilin, Guangxi, China
  • The Second Clinical College of Hainan Medical University — Haikou, Hainan, China
  • Hainan People's Hospital — Haikou, Hainan, China
  • Wuhan Asia Heart Hospital — Wuhan, Hubei, China
  • The Third Xiangya Hospital of Central South University — Changsha, Hunan, China
  • The Second Xiangya Hospital of Central South University — Changsha, Hunan, China
  • GanZhou Municopal Hospital — Ganzhou, Jiangxi, China
  • Shangyou Hospital — Ganzhou, Jiangxi, China
  • Affiliated Hospital, Weifang Medical University — Weifang, Shandong, China
  • The first Affiliated Hospital of Xi'an Jiaotong University — Xi’an, Shanxi, China
  • West China Hospital — Chengdu, Sichuan, China
  • Sichuan Provincial People's Hospital — Chengdu, Sichuan, China
  • Kashgar first people's Hospital — Kashgar, Xinjiang, China
  • The First Affilicated Hospital of Xinjiang Medical University — Ürümqi, Xinjiang, China
  • Yan'an Hospital of Kunming City — Kunming, Yunnan, China
  • Shaoxing people's Hospital — Shaoxing, Zhejiang, China
  • The First Affiliated Hospital of Wenzhou Medical University — Wenzhou, Zhejiang, China
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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