RECRUITING Not applicable ClinicalTrials.gov

Radial vs. State-Of-The-Art Femoral Access for Bleeding and Access Site Complication Reduction in Cardiac Catheterization (REBIRTH)

Sponsor: Minneapolis Heart Institute Foundation • ClinicalTrials.gov ID: NCT04077762

Registry updated: 2026-08-19

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Description

This is a phase IV, prospective, open label, randomized-controlled study that will compare radial access with state-of-the-art femoral access in patients without ST-segment elevation acute myocardial infarction undergoing cardiac catheterization. Subjects will be randomized 1:1 into 2 treatment groups: radial access and state-of-the-art femoral access. Randomization will be performed in blocks of 50 per site. Similarly, a second sub-randomization will be performed in the femoral access group into use of 18 vs 21 gauge needles, also in a 1:1 fashion.

Interventions

Radial Access (Procedure)
Radial Access
State-of-the-art femoral access with 18 gauge needle (Procedure)
State-of-the-art femoral access with 18 gauge needle
State-of-the-art femoral access with 21 gauge needle (Procedure)
State-of-the-art femoral access with 21 gauge needle. For patients randomized to micropuncture (21G) the micropuncture wire must be advanced under fluoroscopy to avoid inadvertent wiring of side-branches.

Eligibility criteria

Inclusion Criteria: * Age 18 years and older * Undergoing diagnostic angiography for ischemic symptoms with possible PCI, or undergoing planned urgent or elective PCI * Has provided informed consent and agrees to participate * Patients must be equally eligible to undergo cardiac catheterization via radial or femoral access Exclusion Criteria: * Primary PCI for STEMI * Planned right heart catheterization * Valvular heart disease requiring valve surgery within 30 days after the index procedure * Hemodialysis access (arteriovenous fistula or graft) in the arm to be used for PCI in case of assignment to radial approach (the opposite arm may be used for radial access if a dialysis graft is present in one) * Peripheral arterial disease prohibiting vascular access * Presence of bilateral internal mammary artery coronary bypass grafts * International normalized ratio ≥1.5 while treated with oral vitamin K antagonists (i.e. warfarin) Receipt of oral factor Xa or IIa inhibitors ≤24 h before procedure * Planned staged PCI within 30 days after index procedure. * Any planned surgeries within 30 days after index procedure * Planned dual arterial access (for example for chronic total occlusion PCI) * Coexisting conditions that limit life expectancy to less than 30 days * Positive pregnancy test

Conditions

Patient Satisfaction Vascular Access Complication

Locations

San Francisco VA Medical Center — San Francisco, California, United States
Mayo Clinic Florida — Jacksonville, Florida, United States
Joseph Maxwell Cleland Atlanta VA Medical Center — Decatur, Georgia, United States
Henry Ford Hospital — Detroit, Michigan, United States
Minneapolis Heart Institute Foundation — Minneapolis, Minnesota, United States
Oklahoma Heart Hospital — Oklahoma City, Oklahoma, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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