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RECRUITING Not applicable ClinicalTrials.gov

TWEAK, a New Biomarker for Predicting Inflammatory Relapses in Multiple Sclerosis

Sponsor: Assistance Publique Hopitaux De Marseille • ClinicalTrials.gov ID: NCT03974997

Registry updated: 2026-09-23
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Description

A significant variation in the serum concentration of the circulating cytokine TWEAK is associated with the onset of an inflammatory attack of MS. Study the concentration variations of the serum soluble form of cytokine TWEAK during the first year of MS and to analyze their correlation with the occurrence of an inflammatory disease outbreak.

Interventions

  • Determination of the circulating serum concentration of cytoquine TWEAK (Diagnostic test)
    Blood samples (20 ml of blood on dry tube) by venipuncture at the bend of the elbow will be made at T0, then monthly for a period of 1 year . The sera will be isolated by centrifugation and then frozen at -80 degrees Assays of the soluble form of TWEAK and TNF will be performed by ELISA blot technique developed by the team.

Eligibility criteria

Inclusion Criteria: * a first episode of inflammation and demyelination of the central nervous system affecting the optic nerve, the spinal cord, one cerebral hemisphere, or the brainstem; or confirmed multiple sclerosis * no differential diagnosis at enrollment based on clinical examination and laboratory tests * compliance with the revised 2017 Mac Donald diagnostic criteria Exclusion Criteria: * age \<18 years old * person in an emergency situation * adult who is subject to a legal protection measure (an adult under guardianship, conservatorship, or judicial protection), or who is unable to give consent * not Enrolled in a Social Security Program * pregnant or breastfeeding woman

Conditions

Multiple Sclerosis

Locations

  • Assistance Publique Hopitaux de Marseille — Marseille, France
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record