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RECRUITING Phase 4 ClinicalTrials.gov

Epinephrine Dose: Optimal Versus Standard Evaluation Trial

Sponsor: Unity Health Toronto • ClinicalTrials.gov ID: NCT03826524

Registry updated: 2026-10-02
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Description

The objective of this randomized controlled trial is to evaluate whether a low cumulative dose of epinephrine ("low dose") is non-inferior to a standard cumulative dose of epinephrine ("standard dose") with respect to survival to hospital discharge among adults undergoing resuscitation for OHCA due to ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT).

Interventions

  • Epinephrine (Drug)
    Epinephrine 1mg 1:10000 (10cc) per dose

Eligibility criteria

Inclusion Criteria: * Out-of-hospital cardiac arrest treated by paramedics AND * Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or confirmed by paramedics or fire services, AND * Established intravenous vascular access Exclusion Criteria: * Known or apparent age \<18 years * Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or confirmed by paramedics * Cardiac arrest due to an obvious non-cardiac primary cause (e.g. blunt or penetrating trauma, exsanguination, burns, drug overdose, drowning, anaphylaxis, sudden asphyxiation, etc.) * Administration of intramuscular, endotracheal tube, or intraosseous epinephrine * Prisoners or persons in police custody * Known allergy or sensitivity to epinephrine

Conditions

Cardiac Arrest, Out-Of-Hospital Sudden Cardiac Arrest Ventricular Fibrillation Ventricular Tachycardia-Pulseless

Locations

  • British Columbia Emergency Health Services (BCEHS) — Victoria, British Columbia, Canada
  • Peel Regional Paramedic Services — Brampton, Ontario, Canada
  • Middlesex-London Paramedic Service — London, Ontario, Canada
  • Halton Region Paramedic Services — Oakville, Ontario, Canada
  • Ottawa Paramedic Services — Ottawa, Ontario, Canada
  • Superior North Emergency Medical Services — Thunder Bay, Ontario, Canada
  • Region of Waterloo Paramedic Services — Waterloo, Ontario, Canada
  • Essex-Windsor Emergency Health Services — Windsor, Ontario, Canada
  • Medavie Health Services West — Saskatoon, Saskatchewan, Canada
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record