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RECRUITING Phase 3 ClinicalTrials.gov

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

Sponsor: SWOG Cancer Research Network • ClinicalTrials.gov ID: NCT03678025

Registry updated: 2026-10-08
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Description

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or spreading.

Interventions

  • Abiraterone (Drug)
    Given PO
  • Bicalutamide (Drug)
    Given PO
  • Degarelix (Drug)
    Given via injection
  • Docetaxel (Drug)
    intravenous
  • Flutamide (Drug)
    Given PO
  • Goserelin Acetate (Drug)
    Given SC
  • Histrelin Acetate (Drug)
    Receive SC
  • Leuprolide Acetate (Drug)
    Receive SC or IM
  • Nilutamide (Drug)
    Given PO
  • Orchiectomy (Procedure)
    Undergo bilateral orchiectomy
  • Prednisone (Drug)
    Given PO
  • Quality-of-Life Assessment (Other)
    Ancillary studies
  • Radiation Therapy (Radiation)
    Standard radiation
  • Radical Prostatectomy (Procedure)
    Standard surgery
  • Triptorelin (Drug)
    injection

Eligibility criteria

Inclusion Criteria: * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: All patients must have a histologically or cytologically proven diagnosis of adenocarcinoma of the prostate. Patients with pure small cell carcinoma\* (SCC), sarcomatoid, or squamous cell carcinoma are not eligible. (\*morphology must be consistent with SCC; synaptophysin or chromogranin positive by immunohistochemical staining is insufficient to diagnose SCC). * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients must have an intact prostate. No prior local therapy for prostate adenocarcinoma is allowed (e.g., brachytherapy, high-intensity focused ultrasound \[HIFU\], cryotherapy, laser ablative therapies). Any prior therapy for benign conditions, such as obstruction, are acceptable (e.g., transurethral resection of the prostate, greenlight laser ablation, microwave ablation). * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients must have evidence of metastatic disease on technetium bone scan and computed tomography (CT) or magnetic resonance imaging (MRI) within 42 days prior to starting standard systemic therapy. Metastatic disease that is detected by positron emission tomography (PET) scan only (sodium fluoride \[NaF\], prostate-specific membrane antigen \[PSMA\], anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid \[FACBC\], carbon \[C\]11) but not conventional imaging (technetium \[Tc\]99 bone scan, CT or MRI) or solitary metastases by conventional imaging, must be confirmed histologically or cytologically. * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients with known brain metastases are not eligible. Brain imaging studies are not required for eligibility if the patient has no neurologic signs or symptoms suggestive of brain metastasis. If brain imaging studies are performed, they must be negative for disease. * STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must have received no more than 28 weeks of standard systemic therapy (SST). SST is defined as current National Comprehensive Cancer Network (NCCN) guidelines for metastatic prostate cancer. * STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must not have progressed while on SST. * STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients with oligometastatic prostate cancer may receive metastasis directed therapy to up to four sites of disease prior to randomization. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a complete physical examination and medical history within 28 days prior to registration. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a PSA documented prior to initiation of SST and within 28 days prior to registration. Any additional PSAs measured while receiving SST should be recorded. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a testosterone lab documented within 28 days prior to randomization. Any additional testosterone labs measured while receiving SST should be recorded as well as pretreatment initiation if available. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, adequately treated stage 0, I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years. * STEP 1 REGISTRATION: SPECIMEN SUBMISSION CRITERIA: Patients must be offered the opportunity to participate in translational medicine studies and specimen banking for future studies. * STEP 1 REGISTRATION: QUALITY OF LIFE CRITERIA: Patients who can complete Patient-Reported Outcome instruments in English, Spanish or French, must participate in the quality of life studies. * STEP 1 REGISTRATION: REGULATORY CRITERIA: Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines. * STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system. * STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: Patients must have no evidence of disease progression during the 28 weeks of SST by PSA measure, bone scan and CT or MRI or symptomatic deterioration (as defined by physician discretion) within 28 days prior to randomization. * STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: Patients must have consultation with a urologist and have surgically resectable disease regardless of definitive treatment intent or randomization. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must have received between 22 and 28 weeks of SST as measured from the date of first hormonal therapy or surgical castration. SST is defined by current NCCN guidelines for metastatic prostate cancer. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must not be planning to receive docetaxel after randomization. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Any toxicities from SST must have resolved to =\< grade 1 (Common Terminology Criteria for Adverse Events \[CTCAE\] version 5.0) prior to randomization. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients may have received elective metastasis directed therapy to oligometastatic sites (=\< 4 sites). All treatment must be completed prior to randomization. * STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a PSA performed within 28 days prior to randomization. * STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a testosterone \< 50 ng/dL within 28 days prior to randomization. * STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a Zubrod performance status of 0 ? 1 within 28 days prior to randomization.

Conditions

Castration Levels of Testosterone Metastatic Prostatic Adenocarcinoma Stage IV Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8

Locations

  • Banner MD Anderson Cancer Center — Gilbert, Arizona, United States
  • Cancer Center at Saint Joseph's — Phoenix, Arizona, United States
  • Mayo Clinic Hospital in Arizona — Phoenix, Arizona, United States
  • Mayo Clinic in Arizona — Scottsdale, Arizona, United States
  • University of Arizona Cancer Center-Orange Grove Campus — Tucson, Arizona, United States
  • University of Arizona Cancer Center-North Campus — Tucson, Arizona, United States
  • University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
  • Kaiser Permanente-Deer Valley Medical Center — Antioch, California, United States
  • Community Cancer Institute — Clovis, California, United States
  • University Oncology Associates — Clovis, California, United States
  • City of Hope Comprehensive Cancer Center — Duarte, California, United States
  • Kaiser Permanente Dublin — Dublin, California, United States
  • Kaiser Permanente-Fremont — Fremont, California, United States
  • Fresno Cancer Center — Fresno, California, United States
  • Kaiser Permanente-Fresno — Fresno, California, United States
  • UC San Diego Moores Cancer Center — La Jolla, California, United States
  • Tibor Rubin VA Medical Center — Long Beach, California, United States
  • Los Angeles County-USC Medical Center — Los Angeles, California, United States
  • USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
  • Fremont - Rideout Cancer Center — Marysville, California, United States
  • Kaiser Permanente-Modesto — Modesto, California, United States
  • Kaiser Permanente Oakland-Broadway — Oakland, California, United States
  • Kaiser Permanente-Oakland — Oakland, California, United States
  • Desert Regional Medical Center — Palm Springs, California, United States
  • Stanford Cancer Institute Palo Alto — Palo Alto, California, United States
  • Kaiser Permanente-Rancho Cordova Cancer Center — Rancho Cordova, California, United States
  • Kaiser Permanente-Redwood City — Redwood City, California, United States
  • Kaiser Permanente-Richmond — Richmond, California, United States
  • Rohnert Park Cancer Center — Rohnert Park, California, United States
  • Kaiser Permanente-Roseville — Roseville, California, United States
  • The Permanente Medical Group-Roseville Radiation Oncology — Roseville, California, United States
  • Kaiser Permanente Downtown Commons — Sacramento, California, United States
  • Mercy Cancer Center - Sacramento — Sacramento, California, United States
  • University of California Davis Comprehensive Cancer Center — Sacramento, California, United States
  • Kaiser Permanente-South Sacramento — Sacramento, California, United States
  • South Sacramento Cancer Center — Sacramento, California, United States
  • Kaiser Permanente-San Francisco — San Francisco, California, United States
  • Kaiser Permanente-Santa Teresa-San Jose — San Jose, California, United States
  • Kaiser Permanente San Leandro — San Leandro, California, United States
  • Pacific Central Coast Health Center-San Luis Obispo — San Luis Obispo, California, United States
  • Kaiser San Rafael-Gallinas — San Rafael, California, United States
  • Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California, United States
  • Kaiser Permanente-Santa Rosa — Santa Rosa, California, United States
  • Kaiser Permanente Cancer Treatment Center — South San Francisco, California, United States
  • Kaiser Permanente-South San Francisco — South San Francisco, California, United States
  • Kaiser Permanente-Stockton — Stockton, California, United States
  • Gene Upshaw Memorial Tahoe Forest Cancer Center — Truckee, California, United States
  • Kaiser Permanente Medical Center-Vacaville — Vacaville, California, United States
  • Kaiser Permanente-Vallejo — Vallejo, California, United States
  • Kaiser Permanente-Walnut Creek — Walnut Creek, California, United States
  • University of Colorado Hospital — Aurora, Colorado, United States
  • Rocky Mountain Cancer Centers-Boulder — Boulder, Colorado, United States
  • UCHealth Memorial Hospital Central — Colorado Springs, Colorado, United States
  • Memorial Hospital North — Colorado Springs, Colorado, United States
  • Porter Adventist Hospital — Denver, Colorado, United States
  • Shaw Cancer Center — Edwards, Colorado, United States
  • Poudre Valley Hospital — Fort Collins, Colorado, United States
  • North Colorado Medical Center — Greeley, Colorado, United States
  • Littleton Adventist Hospital — Littleton, Colorado, United States
  • McKee Medical Center — Loveland, Colorado, United States
  • Parker Adventist Hospital — Parker, Colorado, United States
  • Smilow Cancer Hospital Care Center - Guilford — Guilford, Connecticut, United States
  • Yale University — New Haven, Connecticut, United States
  • Stamford Hospital/Bennett Cancer Center — Stamford, Connecticut, United States
  • Smilow Cancer Hospital Care Center-Trumbull — Trumbull, Connecticut, United States
  • Smilow Cancer Hospital Care Center - Waterford — Waterford, Connecticut, United States
  • Veterans Affairs Connecticut Healthcare System-West Haven Campus — West Haven, Connecticut, United States
  • Helen F Graham Cancer Center — Newark, Delaware, United States
  • Christiana Care Health System-Christiana Hospital — Newark, Delaware, United States
  • MedStar Georgetown University Hospital — Washington D.C., District of Columbia, United States
  • MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
  • George Washington University Medical Center — Washington D.C., District of Columbia, United States
  • Mount Sinai Comprehensive Cancer Center at Aventura — Aventura, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Coral Gables — Coral Gables, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach, Florida, United States
  • Baptist MD Anderson Cancer Center — Jacksonville, Florida, United States
  • University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Kendall — Miami, Florida, United States
  • Mount Sinai Medical Center — Miami Beach, Florida, United States
  • Orlando Health Cancer Institute — Orlando, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Plantation — Plantation, Florida, United States
  • Grady Health System — Atlanta, Georgia, United States
  • Emory University Hospital Midtown — Atlanta, Georgia, United States
  • Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia, United States
  • Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
  • Augusta University Medical Center — Augusta, Georgia, United States
  • Atlanta VA Medical Center — Decatur, Georgia, United States
  • Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Nampa — Nampa, Idaho, United States
  • Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
  • Rush - Copley Medical Center — Aurora, Illinois, United States
  • Illinois CancerCare-Bloomington — Bloomington, Illinois, United States
  • Illinois CancerCare-Canton — Canton, Illinois, United States
  • Illinois CancerCare-Carthage — Carthage, Illinois, United States
  • Northwestern University — Chicago, Illinois, United States
  • Rush University Medical Center — Chicago, Illinois, United States
  • University of Illinois — Chicago, Illinois, United States
  • University of Chicago Comprehensive Cancer Center — Chicago, Illinois, United States
  • Decatur Memorial Hospital — Decatur, Illinois, United States
  • Crossroads Cancer Center — Effingham, Illinois, United States
  • Illinois CancerCare-Eureka — Eureka, Illinois, United States
  • Illinois CancerCare-Galesburg — Galesburg, Illinois, United States
  • Illinois CancerCare-Kewanee Clinic — Kewanee, Illinois, United States
  • Illinois CancerCare-Macomb — Macomb, Illinois, United States
  • Loyola University Medical Center — Maywood, Illinois, United States
  • Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois, United States
  • Illinois CancerCare-Pekin — Pekin, Illinois, United States
  • Illinois CancerCare-Peoria — Peoria, Illinois, United States
  • Methodist Medical Center of Illinois — Peoria, Illinois, United States
  • OSF Saint Francis Medical Center — Peoria, Illinois, United States
  • Illinois CancerCare-Peru — Peru, Illinois, United States
  • Illinois CancerCare-Princeton — Princeton, Illinois, United States
  • Southwest Illinois Health Services LLP — Swansea, Illinois, United States
  • Carle Cancer Center — Urbana, Illinois, United States
  • Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
  • Reid Health — Richmond, Indiana, United States
  • McFarland Clinic - Ames — Ames, Iowa, United States
  • Iowa Methodist Medical Center — Des Moines, Iowa, United States
  • University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
  • University of Kansas Cancer Center — Kansas City, Kansas, United States
  • Olathe Health Cancer Center — Olathe, Kansas, United States
  • University of Kansas Cancer Center-Overland Park — Overland Park, Kansas, United States
  • University of Kansas Hospital-Westwood Cancer Center — Westwood, Kansas, United States
  • Saint Joseph Radiation Oncology Resource Center — Lexington, Kentucky, United States
  • Saint Joseph Hospital East — Lexington, Kentucky, United States
  • University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
  • The James Graham Brown Cancer Center at University of Louisville — Louisville, Kentucky, United States
  • East Jefferson General Hospital — Metairie, Louisiana, United States
  • LSU Healthcare Network / Metairie Multi-Specialty Clinic — Metairie, Louisiana, United States
  • MaineHealth Coastal Cancer Treatment Center — Bath, Maine, United States
  • Lafayette Family Cancer Center-EMMC — Brewer, Maine, United States
  • Maine Medical Center-Bramhall Campus — Portland, Maine, United States
  • MaineHealth Cancer Care Center of York County — Sanford, Maine, United States
  • MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford — Sanford, Maine, United States
  • Maine Medical Center- Scarborough Campus — Scarborough, Maine, United States
  • Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore, Maryland, United States
  • Lahey Hospital and Medical Center — Burlington, Massachusetts, United States
  • Saint Joseph Mercy Hospital — Ann Arbor, Michigan, United States
  • University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
  • Saint Joseph Mercy Brighton — Brighton, Michigan, United States
  • Henry Ford Cancer Institute-Downriver — Brownstown, Michigan, United States
  • Saint Joseph Mercy Canton — Canton, Michigan, United States
  • Saint Joseph Mercy Chelsea — Chelsea, Michigan, United States
  • GenesisCare USA - Clarkston — Clarkston, Michigan, United States
  • Henry Ford Macomb Hospital-Clinton Township — Clinton Township, Michigan, United States
  • Wayne State University/Karmanos Cancer Institute — Detroit, Michigan, United States
  • Henry Ford Hospital — Detroit, Michigan, United States
  • GenesisCare USA - Farmington Hills — Farmington Hills, Michigan, United States
  • Spectrum Health at Butterworth Campus — Grand Rapids, Michigan, United States
  • West Michigan Cancer Center — Kalamazoo, Michigan, United States
  • Sparrow Hospital — Lansing, Michigan, United States
  • GenesisCare USA - Macomb — Macomb, Michigan, United States
  • GenesisCare USA - Madison Heights — Madison Heights, Michigan, United States
  • 21st Century Oncology-Pontiac — Pontiac, Michigan, United States
  • Ascension Saint Mary's Hospital — Saginaw, Michigan, United States
  • Munson Medical Center — Traverse City, Michigan, United States
  • GenesisCare USA - Troy — Troy, Michigan, United States
  • Henry Ford West Bloomfield Hospital — West Bloomfield, Michigan, United States
  • Mercy Hospital — Coon Rapids, Minnesota, United States
  • Fairview Southdale Hospital — Edina, Minnesota, United States
  • Unity Hospital — Fridley, Minnesota, United States
  • Hennepin County Medical Center — Minneapolis, Minnesota, United States
  • Health Partners Inc — Minneapolis, Minnesota, United States
  • North Memorial Medical Health Center — Robbinsdale, Minnesota, United States
  • Mayo Clinic in Rochester — Rochester, Minnesota, United States
  • Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
  • Regions Hospital — Saint Paul, Minnesota, United States
  • Saint Francis Regional Medical Center — Shakopee, Minnesota, United States
  • University of Mississippi Medical Center — Jackson, Mississippi, United States
  • Saint Francis Medical Center — Cape Girardeau, Missouri, United States
  • Southeast Cancer Center — Cape Girardeau, Missouri, United States
  • Siteman Cancer Center at Saint Peters Hospital — City of Saint Peters, Missouri, United States
  • University of Missouri - Ellis Fischel — Columbia, Missouri, United States
  • Siteman Cancer Center at West County Hospital — Creve Coeur, Missouri, United States
  • Freeman Health System — Joplin, Missouri, United States
  • University of Kansas Cancer Center - North — Kansas City, Missouri, United States
  • Delbert Day Cancer Institute at PCRMC — Rolla, Missouri, United States
  • Sainte Genevieve County Memorial Hospital — Sainte Genevieve, Missouri, United States
  • Mercy Hospital Springfield — Springfield, Missouri, United States
  • CoxHealth South Hospital — Springfield, Missouri, United States
  • Washington University School of Medicine — St Louis, Missouri, United States
  • Siteman Cancer Center-South County — St Louis, Missouri, United States
  • Missouri Baptist Medical Center — St Louis, Missouri, United States
  • Siteman Cancer Center at Christian Hospital — St Louis, Missouri, United States
  • Mercy Hospital Saint Louis — St Louis, Missouri, United States
  • Billings Clinic Cancer Center — Billings, Montana, United States
  • Bozeman Deaconess Hospital — Bozeman, Montana, United States
  • Saint James Community Hospital and Cancer Treatment Center — Butte, Montana, United States
  • Benefis Healthcare- Sletten Cancer Institute — Great Falls, Montana, United States
  • Kalispell Regional Medical Center — Kalispell, Montana, United States
  • Nebraska Medicine-Bellevue — Bellevue, Nebraska, United States
  • Nebraska Methodist Hospital — Omaha, Nebraska, United States
  • Nebraska Medicine-Village Pointe — Omaha, Nebraska, United States
  • University of Nebraska Medical Center — Omaha, Nebraska, United States
  • Comprehensive Cancer Centers of Nevada - Henderson — Henderson, Nevada, United States
  • Radiation Oncology Centers of Nevada Central — Las Vegas, Nevada, United States
  • Comprehensive Cancer Centers of Nevada - Northwest — Las Vegas, Nevada, United States
  • Comprehensive Cancer Centers of Nevada-Summerlin — Las Vegas, Nevada, United States
  • Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
  • Comprehensive Cancer Centers of Nevada - Central Valley — Las Vegas, Nevada, United States
  • New Hampshire Oncology Hematology PA-Concord — Concord, New Hampshire, United States
  • Wentworth-Douglass Hospital — Dover, New Hampshire, United States
  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center — Lebanon, New Hampshire, United States
  • Elliot Hospital — Manchester, New Hampshire, United States
  • Solinsky Center for Cancer Care — Manchester, New Hampshire, United States
  • Hackensack University Medical Center — Hackensack, New Jersey, United States
  • Holy Name Hospital — Teaneck, New Jersey, United States
  • Albany Medical Center — Albany, New York, United States
  • Roswell Park Cancer Institute — Buffalo, New York, United States
  • Noyes Memorial Hospital/Myers Cancer Center — Dansville, New York, United States
  • Glens Falls Hospital — Glens Falls, New York, United States
  • Northwell Health/Center for Advanced Medicine — Lake Success, New York, United States
  • NYP/Weill Cornell Medical Center — New York, New York, United States
  • Upstate Cancer Center Radiation Oncology at Oneida — Oneida, New York, United States
  • Upstate Cancer Center Radiation Oncology at Oswego — Oswego, New York, United States
  • Highland Hospital — Rochester, New York, United States
  • University of Rochester — Rochester, New York, United States
  • Stony Brook University Medical Center — Stony Brook, New York, United States
  • State University of New York Upstate Medical University — Syracuse, New York, United States
  • Montefiore Medical Center-Einstein Campus — The Bronx, New York, United States
  • Montefiore Medical Center - Moses Campus — The Bronx, New York, United States
  • James J Peters VA Medical Center — The Bronx, New York, United States
  • Atrium Health Stanly/LCI-Albemarle — Albemarle, North Carolina, United States
  • Mission Hospital — Asheville, North Carolina, United States
  • Carolinas Medical Center/Levine Cancer Institute — Charlotte, North Carolina, United States
  • Atrium Health Pineville/LCI-Pineville — Charlotte, North Carolina, United States
  • Atrium Health University City/LCI-University — Charlotte, North Carolina, United States
  • Levine Cancer Institute-Ballantyne — Charlotte, North Carolina, United States
  • Atrium Health Cabarrus/LCI-Concord — Concord, North Carolina, United States
  • Levine Cancer Institute-Gaston — Gastonia, North Carolina, United States
  • Margaret R Pardee Memorial Hospital — Hendersonville, North Carolina, United States
  • Atrium Health Union/LCI-Union — Monroe, North Carolina, United States
  • CarolinaEast Medical Center — New Bern, North Carolina, United States
  • Cleveland Clinic Mercy Hospital — Canton, Ohio, United States
  • Miami Valley Hospital South — Centerville, Ohio, United States
  • University of Cincinnati Cancer Center-UC Medical Center — Cincinnati, Ohio, United States
  • MetroHealth Medical Center — Cleveland, Ohio, United States
  • Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
  • Miami Valley Hospital North — Dayton, Ohio, United States
  • Greater Dayton Cancer Center — Kettering, Ohio, United States
  • Kettering Medical Center — Kettering, Ohio, United States
  • ProMedica Flower Hospital — Sylvania, Ohio, United States
  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital — Toledo, Ohio, United States
  • University of Toledo — Toledo, Ohio, United States
  • University of Cincinnati Cancer Center-West Chester — West Chester, Ohio, United States
  • University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
  • Legacy Mount Hood Medical Center — Gresham, Oregon, United States
  • Legacy Good Samaritan Hospital and Medical Center — Portland, Oregon, United States
  • Oregon Health and Science University — Portland, Oregon, United States
  • Chambersburg Hospital — Chambersburg, Pennsylvania, United States
  • Geisinger Medical Center — Danville, Pennsylvania, United States
  • Ephrata Cancer Center — Ephrata, Pennsylvania, United States
  • Adams Cancer Center — Gettysburg, Pennsylvania, United States
  • Sechler Family Cancer Center — Lebanon, Pennsylvania, United States
  • Geisinger Medical Oncology-Lewisburg — Lewisburg, Pennsylvania, United States
  • Temple University Hospital — Philadelphia, Pennsylvania, United States
  • University of Pittsburgh Cancer Institute (UPCI) — Pittsburgh, Pennsylvania, United States
  • UPMC-Shadyside Hospital — Pittsburgh, Pennsylvania, United States
  • Geisinger Wyoming Valley/Henry Cancer Center — Wilkes-Barre, Pennsylvania, United States
  • WellSpan Health-York Cancer Center — York, Pennsylvania, United States
  • Prisma Health Cancer Institute - Spartanburg — Boiling Springs, South Carolina, United States
  • Medical University of South Carolina — Charleston, South Carolina, United States
  • Prisma Health Cancer Institute - Faris — Greenville, South Carolina, United States
  • Saint Francis Cancer Center — Greenville, South Carolina, United States
  • Prisma Health Cancer Institute - Eastside — Greenville, South Carolina, United States
  • Prisma Health Cancer Institute - Greer — Greer, South Carolina, United States
  • Carolina Regional Cancer Center — Myrtle Beach, South Carolina, United States
  • Rock Hill Radiation Therapy Center — Rock Hill, South Carolina, United States
  • Levine Cancer Institute-Rock Hill — Rock Hill, South Carolina, United States
  • Prisma Health Cancer Institute - Seneca — Seneca, South Carolina, United States
  • Vanderbilt University/Ingram Cancer Center — Nashville, Tennessee, United States
  • MD Anderson in The Woodlands — Conroe, Texas, United States
  • Parkland Memorial Hospital — Dallas, Texas, United States
  • UT Southwestern Simmons Cancer Center - RedBird — Dallas, Texas, United States
  • UT Southwestern/Simmons Cancer Center-Dallas — Dallas, Texas, United States
  • UT Southwestern/Simmons Cancer Center-Fort Worth — Fort Worth, Texas, United States
  • Lyndon Baines Johnson General Hospital — Houston, Texas, United States
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center — Houston, Texas, United States
  • Ben Taub General Hospital — Houston, Texas, United States
  • Houston Methodist Hospital — Houston, Texas, United States
  • M D Anderson Cancer Center — Houston, Texas, United States
  • Michael E DeBakey VA Medical Center — Houston, Texas, United States
  • MD Anderson West Houston — Houston, Texas, United States
  • MD Anderson League City — League City, Texas, United States
  • UT Southwestern Clinical Center at Richardson/Plano — Richardson, Texas, United States
  • Audie L Murphy VA Hospital — San Antonio, Texas, United States
  • University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
  • MD Anderson in Sugar Land — Sugar Land, Texas, United States
  • Scott and White Memorial Hospital — Temple, Texas, United States
  • American Fork Hospital / Huntsman Intermountain Cancer Center — American Fork, Utah, United States
  • Sandra L Maxwell Cancer Center — Cedar City, Utah, United States
  • Logan Regional Hospital — Logan, Utah, United States
  • Intermountain Medical Center — Murray, Utah, United States
  • McKay-Dee Hospital Center — Ogden, Utah, United States
  • Utah Valley Regional Medical Center — Provo, Utah, United States
  • Riverton Hospital — Riverton, Utah, United States
  • University of Utah Sugarhouse Health Center — Salt Lake City, Utah, United States
  • Utah Cancer Specialists-Salt Lake City — Salt Lake City, Utah, United States
  • Huntsman Cancer Institute/University of Utah — Salt Lake City, Utah, United States
  • LDS Hospital — Salt Lake City, Utah, United States
  • George E Wahlen Department of Veterans Affairs Medical Center — Salt Lake City, Utah, United States
  • Saint George Regional Medical Center — St. George, Utah, United States
  • Central Vermont Medical Center/National Life Cancer Treatment — Berlin Corners, Vermont, United States
  • University of Vermont Medical Center — Burlington, Vermont, United States
  • Bon Secours Saint Francis Medical Center — Midlothian, Virginia, United States
  • Bon Secours Cancer Institute at Reynolds Crossing — Richmond, Virginia, United States
  • VCU Massey Cancer Center at Stony Point — Richmond, Virginia, United States
  • Virginia Commonwealth University/Massey Cancer Center — Richmond, Virginia, United States
  • VCU Community Memorial Health Center — South Hill, Virginia, United States
  • FHCC Overlake — Bellevue, Washington, United States
  • Seattle Cancer Care Alliance at EvergreenHealth — Kirkland, Washington, United States
  • FHCC South Lake Union — Seattle, Washington, United States
  • FHCC at Northwest Hospital — Seattle, Washington, United States
  • University of Washington Medical Center - Montlake — Seattle, Washington, United States
  • Legacy Salmon Creek Hospital — Vancouver, Washington, United States
  • West Virginia University Healthcare — Morgantown, West Virginia, United States
  • Langlade Hospital and Cancer Center — Antigo, Wisconsin, United States
  • Marshfield Medical Center-EC Cancer Center — Eau Claire, Wisconsin, United States
  • Mayo Clinic Health System-Franciscan Healthcare — La Crosse, Wisconsin, United States
  • Marshfield Medical Center-Marshfield — Marshfield, Wisconsin, United States
  • Froedtert Menomonee Falls Hospital — Menomonee Falls, Wisconsin, United States
  • Medical College of Wisconsin — Milwaukee, Wisconsin, United States
  • Zablocki Veterans Administration Medical Center — Milwaukee, Wisconsin, United States
  • Marshfield Clinic-Minocqua Center — Minocqua, Wisconsin, United States
  • Cancer Center of Western Wisconsin — New Richmond, Wisconsin, United States
  • Drexel Town Square Health Center — Oak Creek, Wisconsin, United States
  • Marshfield Medical Center-Rice Lake — Rice Lake, Wisconsin, United States
  • Ascension Saint Michael's Hospital — Stevens Point, Wisconsin, United States
  • Marshfield Medical Center-River Region at Stevens Point — Stevens Point, Wisconsin, United States
  • Aspirus Regional Cancer Center — Wausau, Wisconsin, United States
  • Froedtert West Bend Hospital/Kraemer Cancer Center — West Bend, Wisconsin, United States
  • Diagnostic and Treatment Center — Weston, Wisconsin, United States
  • Marshfield Medical Center - Weston — Weston, Wisconsin, United States
  • Aspirus Cancer Care - Wisconsin Rapids — Wisconsin Rapids, Wisconsin, United States
  • Instituto Nacional del Cancer — Independence, Chile
  • Instituto Nacional De Cancerologia — Bogotá, Colombia
  • Instituto Nacional De Cancerologia de Mexico — Mexico City, Tlalpan, Mexico
  • Kantonsspital Aarau — Aarau, Switzerland
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record