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RECRUITING Phase 4 ClinicalTrials.gov

Vitamin D Homeostasis in Sarcoidosis

Sponsor: University of Texas Southwestern Medical Center • ClinicalTrials.gov ID: NCT03621553

Registry updated: 2026-09-03
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Description

This study evaluates the relationship between vitamin-D status and severity of sarcoidosis, and the effects of vitamin-D repletion in vitamin-D insufficient patients with sarcoidosis. Half the patients with sarcoidosis who are vitamin-D insufficient will receive standard vitamin-D supplementation via standard regimen while the other half will receive a placebo. Sarcoidosis patients who are vitamin-D sufficient will also act as controls.

Interventions

  • Ergocalciferol (Drug)
    Vitamin D2 50,000 units
  • Placebo (Drug)
    Sugar pill manufactured to mimic ergocalciferol 50,000 units
  • Calcium Citrate with Vitamin D2 (Drug)
    To meet the recommended minimum daily dietary requirements

Eligibility criteria

Inclusion Criteria: * Stable medical condition defined as no hospitalization or emergency room visit in the previous 3 months * No evidence of active pulmonary or systemic infection * No other active inflammatory disease, * No active malignancy. * Normal serum ionized calcium level Exclusion Criteria: * Hospitalization or emergency room visit in the previous 3 months * Evidence of active pulmonary or systemic infection * Evidence of active other inflammatory disease * Evidence of active malignancy * Elevated serum ionized calcium level

Conditions

Sarcoidosis Vitamin D Insufficiency

Locations

  • University of Texas Southwestern Medical Center, and Parkland Health and Hospital System — Dallas, Texas, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record