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RECRUITING Early Phase 1 ClinicalTrials.gov

Zinc Oxide Versus Petrolatum Following Skin Surgery

Sponsor: Melissa Pugliano-Mauro • ClinicalTrials.gov ID: NCT03561376

Registry updated: 2026-09-02
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Description

Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will apply respective ointments to each half of scar daily for one month and maintain a log of these activities. They will be seen at 1 week, 4 weeks, 8 weeks, and 6 months post-operatively for photographic scar assessment and to complete the patient portion of the Patient and Observer Scar Assessment Scale (POSAS), a quantitative objective assessment of scar appearance. Trained observers (board-certified dermatologists) will score the observer portion of the scale. POSAS outcomes, post-operative infections, linear density of epidermal seal will be assessed at the 1 week, 4 weeks, 8 weeks, and 6 months post-operative periods and compared between the two groups. Participants will have parking validated for all visits and upon completion of all portions of the study will receive a standardized skin care gift bag containing samples for hypoallergenic skin care products (washes, moisturizers, etc.).

Interventions

  • Topical zinc oxide vs. petrolatum post-surgical scars (Drug)
    Following linear closure on non-scalp skin with scar length \> 4.5 cm, incision site will be "split" and petrolatum applied to one half and zinc oxide ointment to the other half daily for one month following surgery.

Eligibility criteria

Inclusion Criteria: 1. ≥ 18 years of age 2. Linear closure, non-scalp site 3. ≥ 4.5 cm in length (final incision/closure length) 4. End to end symmetry (surgical site is not grossly asymmetric from end to end) 5. Grossly uninfected site Exclusion Criteria: 1. ≤ 18 years 2. Visibly asymmetric linear scar 3. Grossly infected surgical site 4. History of allergy to topical zinc oxide

Conditions

Surgical Incision Surgery--Complications Surgical Wound Surgical Site Infection Scar Hypertrophic Scar

Locations

  • UPMC Dermatology St. Margaret — Pittsburgh, PA, Pennsylvania, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record