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RECRUITING Phase 2 ClinicalTrials.gov

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

Sponsor: National Cancer Institute (NCI) • ClinicalTrials.gov ID: NCT03191149

Registry updated: 2026-10-15
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Description

This phase II trial studies how well osimertinib works in treating patients with non-small cell lung cancer with EGFR exon 20 insertion mutation that is stage IIIB-IV or has come back after a period of improvement (recurrent). Osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Interventions

  • Biospecimen Collection (Procedure)
    Undergo collection of blood samples
  • Computed Tomography with Contrast (Procedure)
    Undergo CT with contrast
  • Echocardiography Test (Procedure)
    Undergo ECHO
  • Magnetic Resonance Imaging (Procedure)
    Undergo MRI
  • Multigated Acquisition Scan (Procedure)
    Undergo MUGA
  • Osimertinib (Drug)
    Given PO

Eligibility criteria

Inclusion Criteria: * Participants must have a pathologically-confirmed diagnosis of non-small cell lung cancer (NSCLC) * Participants must have advanced disease - either stage IV disease, stage IIIB disease not amenable to definitive multi-modality therapy, or recurrent disease after a prior diagnosis of stage I-III disease. All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 7th edition staging criteria * An EGFR exon 20 insertion mutation must be detected in the tumor tissue. Patients may be enrolled in the study based on an exon 20 insertion EGFR mutation detected by any Clinical Laboratory Improvement Act (CLIA)-certified tissue assay * NOTE: Testing results are to be submitted via Medidata Rave and the study chair or delegate will review the reports * Patients must have measurable disease; baseline measurements and ALL sites of disease must be obtained within 4 weeks to registration * Patients must have previously received at least one line of therapy for their advanced lung cancer; there are no restrictions on the maximum number of prior therapies allowed * Participants must not have previously received osimertinib * Participants must have not previously received therapies targeting PDL1, PD1 or CTLA4 within 6 months (180 days) prior to registration * Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) performance status =\< 1 * Hemoglobin \>= 9.0 g/L (within 4 weeks before registration) * Leukocytes/white blood cells \>= 3,000/mcL (within 4 weeks before registration) * Absolute neutrophil count \>= 1,500/mcL (within 4 weeks before registration) * Platelets \>= 100,000/mcL (within 4 weeks before registration) * Total bilirubin =\< 1.5 x upper limit of normal (ULN) if no liver metastases or =\< 3 times ULN in the presence of documented Gilbert's syndrome (unconjugated hyperbilirubinemia) or liver metastases (within 4 weeks before registration) * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 3 x institutional upper limit of normal; for patients with known hepatic metastases AST and/or ALT =\< 5 x ULN (within 4 weeks before registration) * Creatinine =\< 1.5 x institutional upper limit of normal (within 4 weeks before registration) * Participants may not have clinically active or symptomatic interstitial lung disease or interstitial pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention), or a history of clinically significant interstitial lung disease or radiation pneumonitis * Participants may not have had radiation to the lung fields within four weeks (28 days) of starting treatment. For patients receiving palliative radiation to thoracic vertebrae, ribs or other sites where the radiation field includes the lungs, radiation must be completed at least two weeks before starting treatment. For all palliative radiation to all other sites, at least 7 days must have elapsed prior to starting treatment. At least six months (180 days) must have elapsed prior to starting treatment for radiation given with curative intent. Palliative radiotherapy to control symptoms (including gamma knife technique) is permitted. For stereotactic radiosurgery (SRS) to central nervous system (CNS) lesions, osimertinib can be held on the day of radiation only. For palliative radiotherapy (RT) to other sites of disease outside of the thorax osimertinib (osi) should be held for a minimum of 3 days before radiation and 3 days after RT is completed, but the duration of washout can be adjusted at the investigator's discretion with the approval of the study principal investigator (PI). For thoracic radiation, a 7-10 day washout period before the procedure and one week period after procedure before restarting osimertinib is advised to minimize the risk of pneumonitis. All radiotherapy related toxicities should be managed and ideally resolved before restarting osimertinib. Investigators should consider the radiotherapy when assessing causality if there are any localized adverse events (AEs) following the procedure * Participants may not have clinically symptomatic brain metastases, leptomeningeal disease, or spinal cord compression. Patients may be on a stable dose of corticosteroids to control brain metastases if they have been on a stable dose for two weeks (14 days) prior to study treatment and are clinically asymptomatic * Patients must have an ECHO or a nuclear study (MUGA or first pass) within 4 weeks (28 days) prior to registration to treatment and must not have a left ventricular ejection fraction (LVEF) \< institutional lower limit of normal (LLN). If the LLN is not defined at a site, the LVEF must be \>= 50% for the patient to be eligible * Participants may not have any of the following cardiac criteria: * Mean resting corrected QT interval (QTc) \>= 470 msec obtained from 3 electrocardiograms (ECGs) using the screening clinic ECG machine-derived QTc value * No history of QT prolongation associated with other medications that required discontinuation of that medication * Patient must not be receiving any concomitant medications that are known to be associated with Torsades de Pointes * Any clinically important abnormalities in rhythm, conduction or morphology of resting ECG e.g., complete left bundle branch block, third degree heart block, second degree heart block, any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, electrolyte abnormalities (including: serum/plasma potassium \< LLN; serum/plasma magnesium \< LLN; serum/plasma calcium \< LLN), congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age in first degree relatives or any concomitant medication known to prolong the QT interval * Symptomatic heart failure - New York Heart Association (NYHA) grade II-IV * Participants may not have a second, clinically active, cancer. Patients with second cancers which have been treated with curative intent and/or are currently inactive are allowed * Participants may not be receiving any other investigational agents. Patients previously treated with investigational agents must complete a washout period of at least two weeks or five half-lives, whichever is longer, before starting treatment * Participants may not have uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Patients must have no history of hypersensitivity active or inactive excipients of osimertinib (AZD9291) or drugs with a similar chemical structure or class to osimertinib (AZD9291) * Patients must not currently be receiving (or unable to stop use prior to receiving the first dose of study treatment) medications or herbal supplements known to be potent inducers of CYP3A4 (at least 3 week prior). All patients must try to avoid concomitant use of any medications, herbal supplements and/or ingestion of foods with known inducer effects on CYP3A4 * If medically feasible, patients taking regular medication, with the exception of potent inducers of CYP3A4, should be maintained on it throughout the study period. Patients taking concomitant medications whose disposition is dependent upon breast cancer resistance protein (BCRP) or P-glycoprotein (Pgp) and which have a narrow therapeutic index should be closely monitored for signs of changed tolerability as a result of increased exposure of the concomitant medication whilst receiving osimertinib (AZD9291) * NOTE: Use of St John's wort is a contra-indication for osimertinib (AZD9291) use * If applicable, it is recommended that the starting and maintenance dose of rosuvastatin (due to BCRP inhibition by AZD9291 \[osimertinib\]) should be as low as possible and should be guided by the statin label. Monitoring of low-density lipoprotein (LDL) cholesterol levels is advised. If the subject experiences any potentially relevant adverse events suggestive of muscle toxicity including unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever, the statin should be stopped, creatine kinase (CK) levels should be checked, and any appropriate further management should be taken * Subjects taking warfarin should be monitored regularly for changes in prothrombin time or international normalized ratio (INR) * No unresolved toxicities from prior therapy greater than Common Terminology Criteria for Adverse Events (CTCAE) grade 1 at the time of starting study treatment, with the exception of alopecia and grade 2, prior platinum-therapy-related neuropathy * Patients with refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of osimertinib (AZD9291) are ineligible * Women must not be pregnant or breast-feeding because osimertinib (AZD9291) has been shown to cause fetal harm in animal models. All females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) * Women of childbearing potential (WOCBP) and sexually active males must use an accepted and effective method of contraception while receiving protocol treatment or abstain from sexual intercourse for the duration of their participation in the study. WOCBP must use birth control for two weeks prior to the start of the treatment and continue for 6 weeks after the last dose of the study drug. Sexually active male patients must use effective contraception from day 1 of treatment and continue for 4 months after the last dose of the study drug * Other anticancer agents and investigational agents should not be given while the subject is on study treatment * Supportive care and other medications that are considered necessary for the subject's wellbeing may be given at the discretion of the investigator * A guidance regarding potential interactions with concomitant medications is provided

Conditions

Advanced Lung Non-Small Cell Carcinoma Recurrent Lung Non-Small Cell Carcinoma Stage IIIB Lung Non-Small Cell Cancer AJCC v7 Stage IV Lung Non-Small Cell Cancer AJCC v7

Locations

  • Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
  • Anchorage Radiation Therapy Center — Anchorage, Alaska, United States
  • Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
  • Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
  • Alaska Women's Cancer Care — Anchorage, Alaska, United States
  • Anchorage Oncology Centre — Anchorage, Alaska, United States
  • Katmai Oncology Group — Anchorage, Alaska, United States
  • Providence Alaska Medical Center — Anchorage, Alaska, United States
  • Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
  • Mercy Hospital Fort Smith — Fort Smith, Arkansas, United States
  • CARTI Cancer Center — Little Rock, Arkansas, United States
  • Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
  • MedStar Georgetown University Hospital — Washington D.C., District of Columbia, United States
  • Holy Cross Hospital — Fort Lauderdale, Florida, United States
  • Emory University Hospital Midtown — Atlanta, Georgia, United States
  • Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia, United States
  • Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
  • Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho, United States
  • Saint Luke's Cancer Institute - Boise — Boise, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
  • Kootenai Health - Coeur d'Alene — Coeur d'Alene, Idaho, United States
  • Walter Knox Memorial Hospital — Emmett, Idaho, United States
  • Saint Luke's Cancer Institute - Fruitland — Fruitland, Idaho, United States
  • Idaho Urologic Institute-Meridian — Meridian, Idaho, United States
  • Saint Luke's Cancer Institute - Meridian — Meridian, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Nampa — Nampa, Idaho, United States
  • Saint Luke's Cancer Institute - Nampa — Nampa, Idaho, United States
  • Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
  • Kootenai Clinic Cancer Services - Sandpoint — Sandpoint, Idaho, United States
  • Saint Luke's Cancer Institute - Twin Falls — Twin Falls, Idaho, United States
  • OSF Saint Anthony's Health Center — Alton, Illinois, United States
  • Rush-Copley Medical Center — Aurora, Illinois, United States
  • Illinois CancerCare-Bloomington — Bloomington, Illinois, United States
  • Illinois CancerCare-Canton — Canton, Illinois, United States
  • Memorial Hospital of Carbondale — Carbondale, Illinois, United States
  • SIH Cancer Institute — Carterville, Illinois, United States
  • Illinois CancerCare-Carthage — Carthage, Illinois, United States
  • Centralia Oncology Clinic — Centralia, Illinois, United States
  • Saint Mary's Hospital — Centralia, Illinois, United States
  • Carle at The Riverfront — Danville, Illinois, United States
  • Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois, United States
  • Decatur Memorial Hospital — Decatur, Illinois, United States
  • Illinois CancerCare-Dixon — Dixon, Illinois, United States
  • Carle Physician Group-Effingham — Effingham, Illinois, United States
  • Crossroads Cancer Center — Effingham, Illinois, United States
  • Illinois CancerCare-Eureka — Eureka, Illinois, United States
  • NorthShore University HealthSystem-Evanston Hospital — Evanston, Illinois, United States
  • Illinois CancerCare-Galesburg — Galesburg, Illinois, United States
  • Western Illinois Cancer Treatment Center — Galesburg, Illinois, United States
  • NorthShore University HealthSystem-Glenbrook Hospital — Glenview, Illinois, United States
  • NorthShore University HealthSystem-Highland Park Hospital — Highland Park, Illinois, United States
  • Illinois CancerCare-Kewanee Clinic — Kewanee, Illinois, United States
  • Illinois CancerCare-Macomb — Macomb, Illinois, United States
  • Carle Physician Group-Mattoon/Charleston — Mattoon, Illinois, United States
  • SSM Health Good Samaritan — Mount Vernon, Illinois, United States
  • Cancer Care Center of O'Fallon — O'Fallon, Illinois, United States
  • HSHS Saint Elizabeth's Hospital — O'Fallon, Illinois, United States
  • Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois, United States
  • Illinois CancerCare-Pekin — Pekin, Illinois, United States
  • Illinois CancerCare-Peoria — Peoria, Illinois, United States
  • Methodist Medical Center of Illinois — Peoria, Illinois, United States
  • Illinois CancerCare-Peru — Peru, Illinois, United States
  • Valley Radiation Oncology — Peru, Illinois, United States
  • Illinois CancerCare-Princeton — Princeton, Illinois, United States
  • North Shore Medical Center — Skokie, Illinois, United States
  • Southern Illinois University School of Medicine — Springfield, Illinois, United States
  • Springfield Clinic — Springfield, Illinois, United States
  • Springfield Memorial Hospital — Springfield, Illinois, United States
  • Southwest Illinois Health Services LLP — Swansea, Illinois, United States
  • Carle Cancer Center — Urbana, Illinois, United States
  • The Carle Foundation Hospital — Urbana, Illinois, United States
  • Illinois CancerCare - Washington — Washington, Illinois, United States
  • Rush-Copley Healthcare Center — Yorkville, Illinois, United States
  • Midwestern Regional Medical Center — Zion, Illinois, United States
  • Reid Health — Richmond, Indiana, United States
  • Heartland Oncology and Hematology LLP — Council Bluffs, Iowa, United States
  • Methodist Jennie Edmundson Hospital — Council Bluffs, Iowa, United States
  • Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ — Council Bluffs, Iowa, United States
  • Iowa Methodist Medical Center — Des Moines, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Des Moines Clinic — Des Moines, Iowa, United States
  • Broadlawns Medical Center — Des Moines, Iowa, United States
  • Iowa Lutheran Hospital — Des Moines, Iowa, United States
  • UI Healthcare Mission Cancer and Blood - Fort Dodge — Fort Dodge, Iowa, United States
  • Methodist West Hospital — West Des Moines, Iowa, United States
  • Central Care Cancer Center - Garden City — Garden City, Kansas, United States
  • Central Care Cancer Center - Great Bend — Great Bend, Kansas, United States
  • Mercy Hospital Pittsburg — Pittsburg, Kansas, United States
  • Ochsner Health Center-Summa — Baton Rouge, Louisiana, United States
  • Medical Center of Baton Rouge — Baton Rouge, Louisiana, United States
  • Ochsner High Grove — Baton Rouge, Louisiana, United States
  • Ochsner Medical Center Jefferson — New Orleans, Louisiana, United States
  • MedStar Franklin Square Medical Center/Weinberg Cancer Institute — Baltimore, Maryland, United States
  • Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore, Maryland, United States
  • Massachusetts General Hospital Cancer Center — Boston, Massachusetts, United States
  • Brigham and Women's Hospital — Boston, Massachusetts, United States
  • Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
  • Dana-Farber Cancer Institute — Boston, Massachusetts, United States
  • Mercy Medical Center — Springfield, Massachusetts, United States
  • MyMichigan Medical Center Gratiot — Alma, Michigan, United States
  • MyMichigan Medical Center Alpena — Alpena, Michigan, United States
  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor — Ann Arbor, Michigan, United States
  • Bronson Battle Creek — Battle Creek, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology - Brighton — Brighton, Michigan, United States
  • Trinity Health Medical Center - Brighton — Brighton, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology - Canton — Canton, Michigan, United States
  • Trinity Health Medical Center - Canton — Canton, Michigan, United States
  • Caro Cancer Center — Caro, Michigan, United States
  • Chelsea Hospital — Chelsea, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital — Chelsea, Michigan, United States
  • Hematology Oncology Consultants-Clarkston — Clarkston, Michigan, United States
  • Newland Medical Associates-Clarkston — Clarkston, Michigan, United States
  • Trinity Health IHA Medical Group - Primary Care - Clarkston — Clarkston, Michigan, United States
  • Henry Ford Hospital — Detroit, Michigan, United States
  • Henry Ford Health Saint John Hospital — Detroit, Michigan, United States
  • Henry Ford River District Hospital — East China Township, Michigan, United States
  • Cancer Hematology Centers - Flint — Flint, Michigan, United States
  • Genesee Hematology Oncology PC — Flint, Michigan, United States
  • Genesys Hurley Cancer Institute — Flint, Michigan, United States
  • Hurley Medical Center — Flint, Michigan, United States
  • MyMichigan Medical Center Gladwin — Gladwin, Michigan, United States
  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital — Grand Rapids, Michigan, United States
  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital — Grand Rapids, Michigan, United States
  • Trinity Health Grand Rapids Hospital — Grand Rapids, Michigan, United States
  • Henry Ford Saint John Hospital - Academic — Grosse Pointe Woods, Michigan, United States
  • Henry Ford Saint John Hospital - Breast — Grosse Pointe Woods, Michigan, United States
  • Henry Ford Saint John Hospital - Van Elslander — Grosse Pointe Woods, Michigan, United States
  • Bronson Methodist Hospital — Kalamazoo, Michigan, United States
  • West Michigan Cancer Center — Kalamazoo, Michigan, United States
  • Beacon Kalamazoo Cancer Center — Kalamazoo, Michigan, United States
  • Beacon Kalamazoo — Kalamazoo, Michigan, United States
  • University of Michigan Health - Sparrow Lansing — Lansing, Michigan, United States
  • Hope Cancer Clinic — Livonia, Michigan, United States
  • Trinity Health Saint Mary Mercy Livonia Hospital — Livonia, Michigan, United States
  • Henry Ford Saint John Hospital - Macomb Medical — Macomb, Michigan, United States
  • Henry Ford Warren Hospital - Breast Macomb — Macomb, Michigan, United States
  • Saint Mary's Oncology/Hematology Associates of Marlette — Marlette, Michigan, United States
  • MyMichigan Medical Center Midland — Midland, Michigan, United States
  • MyMichigan Medical Center Mount Pleasant — Mount Pleasant, Michigan, United States
  • Trinity Health Muskegon Hospital — Muskegon, Michigan, United States
  • Corewell Health Lakeland Hospitals - Niles Hospital — Niles, Michigan, United States
  • Cancer and Hematology Centers of Western Michigan - Norton Shores — Norton Shores, Michigan, United States
  • Henry Ford Health Providence Novi Hospital — Novi, Michigan, United States
  • Hope Cancer Center — Pontiac, Michigan, United States
  • Michigan Healthcare Professionals Pontiac — Pontiac, Michigan, United States
  • Newland Medical Associates-Pontiac — Pontiac, Michigan, United States
  • Trinity Health Saint Joseph Mercy Oakland Hospital — Pontiac, Michigan, United States
  • Corewell Health Reed City Hospital — Reed City, Michigan, United States
  • Henry Ford Rochester Hospital — Rochester Hills, Michigan, United States
  • MyMichigan Medical Center Saginaw — Saginaw, Michigan, United States
  • Oncology Hematology Associates of Saginaw Valley PC — Saginaw, Michigan, United States
  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center — Saint Joseph, Michigan, United States
  • Corewell Health Lakeland Hospitals - Saint Joseph Hospital — Saint Joseph, Michigan, United States
  • Henry Ford Health Providence Southfield Hospital — Southfield, Michigan, United States
  • Bhadresh Nayak MD PC-Sterling Heights — Sterling Heights, Michigan, United States
  • MyMichigan Medical Center Tawas — Tawas City, Michigan, United States
  • Munson Medical Center — Traverse City, Michigan, United States
  • Advanced Breast Care Center PLLC — Warren, Michigan, United States
  • Henry Ford Health Warren Hospital — Warren, Michigan, United States
  • Henry Ford Madison Heights Hospital - Breast — Warren, Michigan, United States
  • Henry Ford Warren Hospital - GLCMS — Warren, Michigan, United States
  • Macomb Hematology Oncology PC — Warren, Michigan, United States
  • Saint Mary's Oncology/Hematology Associates of West Branch — West Branch, Michigan, United States
  • University of Michigan Health - West — Wyoming, Michigan, United States
  • Huron Gastroenterology PC — Ypsilanti, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus — Ypsilanti, Michigan, United States
  • Fairview Ridges Hospital — Burnsville, Minnesota, United States
  • Minnesota Oncology - Burnsville — Burnsville, Minnesota, United States
  • Cambridge Medical Center — Cambridge, Minnesota, United States
  • Minnesota Oncology Hematology PA-Chaska — Chaska, Minnesota, United States
  • Mercy Hospital — Coon Rapids, Minnesota, United States
  • Minnesota Oncology - Coon Rapids — Coon Rapids, Minnesota, United States
  • Fairview Southdale Hospital — Edina, Minnesota, United States
  • Minnesota Oncology - Edina — Edina, Minnesota, United States
  • Unity Hospital — Fridley, Minnesota, United States
  • Fairview Clinics and Surgery Center Maple Grove — Maple Grove, Minnesota, United States
  • HealthPartners Cancer Care - Park Nicollet Maple Grove — Maple Grove, Minnesota, United States
  • Minnesota Oncology - Maple Grove — Maple Grove, Minnesota, United States
  • Minnesota Oncology Hematology PA-Maplewood — Maplewood, Minnesota, United States
  • Saint John's Hospital - Healtheast — Maplewood, Minnesota, United States
  • Abbott-Northwestern Hospital — Minneapolis, Minnesota, United States
  • Health Partners Inc — Minneapolis, Minnesota, United States
  • Monticello Cancer Center — Monticello, Minnesota, United States
  • New Ulm Medical Center — New Ulm, Minnesota, United States
  • Fairview Northland Medical Center — Princeton, Minnesota, United States
  • North Memorial Medical Health Center — Robbinsdale, Minnesota, United States
  • Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
  • Regions Hospital — Saint Paul, Minnesota, United States
  • United Hospital — Saint Paul, Minnesota, United States
  • Saint Francis Regional Medical Center — Shakopee, Minnesota, United States
  • Lakeview Hospital — Stillwater, Minnesota, United States
  • Ridgeview Medical Center — Waconia, Minnesota, United States
  • Rice Memorial Hospital — Willmar, Minnesota, United States
  • Fairview Cancer Center - Woodbury — Woodbury, Minnesota, United States
  • Minnesota Oncology Hematology PA-Woodbury — Woodbury, Minnesota, United States
  • Fairview Lakes Medical Center — Wyoming, Minnesota, United States
  • Mercy Oncology and Hematology - Clayton-Clarkson — Ballwin, Missouri, United States
  • Central Care Cancer Center - Bolivar — Bolivar, Missouri, United States
  • Parkland Health Center-Bonne Terre — Bonne Terre, Missouri, United States
  • Cox Cancer Center Branson — Branson, Missouri, United States
  • Mercy Cancer Center - Cape Girardeau — Cape Girardeau, Missouri, United States
  • Saint Francis Medical Center — Cape Girardeau, Missouri, United States
  • Parkland Health Center - Farmington — Farmington, Missouri, United States
  • MU Health Care Goldschmidt Cancer Center — Jefferson City, Missouri, United States
  • Freeman Health System — Joplin, Missouri, United States
  • Mercy Hospital Joplin — Joplin, Missouri, United States
  • Lake Regional Hospital — Osage Beach, Missouri, United States
  • Mercy Clinic-Rolla-Cancer and Hematology — Rolla, Missouri, United States
  • Phelps Health Delbert Day Cancer Institute — Rolla, Missouri, United States
  • Heartland Regional Medical Center — Saint Joseph, Missouri, United States
  • Sainte Genevieve County Memorial Hospital — Sainte Genevieve, Missouri, United States
  • Mercy Hospital Springfield — Springfield, Missouri, United States
  • CoxHealth South Hospital — Springfield, Missouri, United States
  • Mercy Infusion Center - Chippewa — St Louis, Missouri, United States
  • Mercy Hospital South — St Louis, Missouri, United States
  • Missouri Baptist Medical Center — St Louis, Missouri, United States
  • Mercy Hospital Saint Louis — St Louis, Missouri, United States
  • Missouri Baptist Sullivan Hospital — Sullivan, Missouri, United States
  • Mercy Hospital Washington — Washington, Missouri, United States
  • Community Hospital of Anaconda — Anaconda, Montana, United States
  • Billings Clinic Cancer Center — Billings, Montana, United States
  • Bozeman Health Deaconess Hospital — Bozeman, Montana, United States
  • Benefis Sletten Cancer Institute — Great Falls, Montana, United States
  • Great Falls Clinic — Great Falls, Montana, United States
  • Hi-Line Sletten Cancer Center — Havre, Montana, United States
  • Benefis Helena Specialty Center — Helena, Montana, United States
  • Saint Peter's Community Hospital — Helena, Montana, United States
  • Logan Health Medical Center — Kalispell, Montana, United States
  • Saint Patrick Hospital - Community Hospital — Missoula, Montana, United States
  • Community Medical Center — Missoula, Montana, United States
  • Nebraska Cancer Specialists/Oncology Hematology West PC - MECC — Omaha, Nebraska, United States
  • Nebraska Methodist Hospital — Omaha, Nebraska, United States
  • Oncology Associates PC — Omaha, Nebraska, United States
  • Roswell Park Cancer Institute — Buffalo, New York, United States
  • Garnet Health Medical Center — Middletown, New York, United States
  • Dickstein Cancer Treatment Center — White Plains, New York, United States
  • Margaret R Pardee Memorial Hospital — Hendersonville, North Carolina, United States
  • FirstHealth of the Carolinas-Moore Regional Hospital — Pinehurst, North Carolina, United States
  • Indu and Raj Soin Medical Center — Beavercreek, Ohio, United States
  • Saint Elizabeth Boardman Hospital — Boardman, Ohio, United States
  • Dayton Physicians LLC-Miami Valley South — Centerville, Ohio, United States
  • Miami Valley Hospital South — Centerville, Ohio, United States
  • Oncology Hematology Care Inc-Kenwood — Cincinnati, Ohio, United States
  • MetroHealth Medical Center — Cleveland, Ohio, United States
  • Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
  • Good Samaritan Hospital - Dayton — Dayton, Ohio, United States
  • Miami Valley Hospital — Dayton, Ohio, United States
  • Dayton Physician LLC - Englewood — Dayton, Ohio, United States
  • Miami Valley Hospital North — Dayton, Ohio, United States
  • Armes Family Cancer Center — Findlay, Ohio, United States
  • Blanchard Valley Hospital — Findlay, Ohio, United States
  • Orion Cancer Care — Findlay, Ohio, United States
  • Atrium Medical Center-Middletown Regional Hospital — Franklin, Ohio, United States
  • Dayton Physicians LLC-Atrium — Franklin, Ohio, United States
  • Dayton Physicians LLC-Wayne — Greenville, Ohio, United States
  • Wayne Hospital — Greenville, Ohio, United States
  • Greater Dayton Cancer Center — Kettering, Ohio, United States
  • First Dayton Cancer Care — Kettering, Ohio, United States
  • Kettering Medical Center — Kettering, Ohio, United States
  • Springfield Regional Cancer Center — Springfield, Ohio, United States
  • Springfield Regional Medical Center — Springfield, Ohio, United States
  • Dayton Physicians LLC - Troy — Troy, Ohio, United States
  • Upper Valley Medical Center — Troy, Ohio, United States
  • Saint Joseph Warren Hospital — Warren, Ohio, United States
  • Saint Elizabeth Youngstown Hospital — Youngstown, Ohio, United States
  • University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
  • Mercy Hospital Oklahoma City — Oklahoma City, Oklahoma, United States
  • Saint Alphonsus Cancer Care Center-Baker City — Baker City, Oregon, United States
  • Saint Charles Health System — Bend, Oregon, United States
  • Clackamas Radiation Oncology Center — Clackamas, Oregon, United States
  • Providence Cancer Institute Clackamas Clinic — Clackamas, Oregon, United States
  • Bay Area Hospital — Coos Bay, Oregon, United States
  • Good Samaritan Hospital — Corvallis, Oregon, United States
  • Providence Newberg Medical Center — Newberg, Oregon, United States
  • Saint Alphonsus Cancer Care Center-Ontario — Ontario, Oregon, United States
  • Providence Willamette Falls Medical Center — Oregon City, Oregon, United States
  • Providence Portland Medical Center — Portland, Oregon, United States
  • Providence Saint Vincent Medical Center — Portland, Oregon, United States
  • Saint Charles Health System-Redmond — Redmond, Oregon, United States
  • Lehigh Valley Hospital-Cedar Crest — Allentown, Pennsylvania, United States
  • Lehigh Valley Hospital - Muhlenberg — Bethlehem, Pennsylvania, United States
  • Bryn Mawr Hospital — Bryn Mawr, Pennsylvania, United States
  • Main Line Health Center-Collegeville — Collegeville, Pennsylvania, United States
  • Pocono Medical Center — East Stroudsburg, Pennsylvania, United States
  • Main Line Health Center-Exton — Exton, Pennsylvania, United States
  • Lehigh Valley Hospital-Hazleton — Hazleton, Pennsylvania, United States
  • Riddle Memorial Hospital — Media, Pennsylvania, United States
  • Bryn Mawr Health Center — Newtown Square, Pennsylvania, United States
  • Paoli Memorial Hospital — Paoli, Pennsylvania, United States
  • Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
  • Temple University Hospital — Philadelphia, Pennsylvania, United States
  • Penn State Health Saint Joseph Medical Center — Reading, Pennsylvania, United States
  • Lankenau Medical Center — Wynnewood, Pennsylvania, United States
  • University of Virginia Cancer Center — Charlottesville, Virginia, United States
  • Providence Regional Cancer System-Aberdeen — Aberdeen, Washington, United States
  • PeaceHealth Saint Joseph Medical Center — Bellingham, Washington, United States
  • Providence Regional Cancer System-Centralia — Centralia, Washington, United States
  • Swedish Cancer Institute-Edmonds — Edmonds, Washington, United States
  • Providence Regional Cancer Partnership — Everett, Washington, United States
  • Swedish Cancer Institute-Issaquah — Issaquah, Washington, United States
  • Kadlec Clinic Hematology and Oncology — Kennewick, Washington, United States
  • Providence Regional Cancer System-Lacey — Lacey, Washington, United States
  • PeaceHealth Saint John Medical Center — Longview, Washington, United States
  • Pacific Gynecology Specialists — Seattle, Washington, United States
  • Swedish Medical Center-Ballard Campus — Seattle, Washington, United States
  • Fred Hutchinson Cancer Center — Seattle, Washington, United States
  • Kaiser Permanente Washington — Seattle, Washington, United States
  • Swedish Medical Center-Cherry Hill — Seattle, Washington, United States
  • Swedish Medical Center-First Hill — Seattle, Washington, United States
  • University of Washington Medical Center - Montlake — Seattle, Washington, United States
  • PeaceHealth United General Medical Center — Sedro-Woolley, Washington, United States
  • Providence Regional Cancer System-Shelton — Shelton, Washington, United States
  • PeaceHealth Southwest Medical Center — Vancouver, Washington, United States
  • Providence Saint Mary Regional Cancer Center — Walla Walla, Washington, United States
  • Providence Regional Cancer System-Yelm — Yelm, Washington, United States
  • Aurora Cancer Care-Southern Lakes VLCC — Burlington, Wisconsin, United States
  • Marshfield Clinic-Chippewa Center — Chippewa Falls, Wisconsin, United States
  • Aurora Saint Luke's South Shore — Cudahy, Wisconsin, United States
  • Marshfield Medical Center-EC Cancer Center — Eau Claire, Wisconsin, United States
  • Aurora Health Center-Fond du Lac — Fond du Lac, Wisconsin, United States
  • Aurora Health Care Germantown Health Center — Germantown, Wisconsin, United States
  • Aurora Cancer Care-Grafton — Grafton, Wisconsin, United States
  • Aurora BayCare Medical Center — Green Bay, Wisconsin, United States
  • Aurora Cancer Care-Kenosha South — Kenosha, Wisconsin, United States
  • Gundersen Lutheran Medical Center — La Crosse, Wisconsin, United States
  • Marshfield Medical Center - Ladysmith — Ladysmith, Wisconsin, United States
  • Aurora Bay Area Medical Group-Marinette — Marinette, Wisconsin, United States
  • Marshfield Medical Center-Marshfield — Marshfield, Wisconsin, United States
  • Aurora Cancer Care-Milwaukee — Milwaukee, Wisconsin, United States
  • Aurora Saint Luke's Medical Center — Milwaukee, Wisconsin, United States
  • Aurora Sinai Medical Center — Milwaukee, Wisconsin, United States
  • Marshfield Medical Center - Minocqua — Minocqua, Wisconsin, United States
  • Cancer Center of Western Wisconsin — New Richmond, Wisconsin, United States
  • Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin, United States
  • Aurora Cancer Care-Racine — Racine, Wisconsin, United States
  • Marshfield Medical Center-Rice Lake — Rice Lake, Wisconsin, United States
  • Vince Lombardi Cancer Clinic-Sheboygan — Sheboygan, Wisconsin, United States
  • Marshfield Medical Center-River Region at Stevens Point — Stevens Point, Wisconsin, United States
  • Aurora Medical Center in Summit — Summit, Wisconsin, United States
  • Vince Lombardi Cancer Clinic-Two Rivers — Two Rivers, Wisconsin, United States
  • Marshfield Clinic-Wausau Center — Wausau, Wisconsin, United States
  • Aurora Cancer Care-Milwaukee West — Wauwatosa, Wisconsin, United States
  • Aurora West Allis Medical Center — West Allis, Wisconsin, United States
  • Marshfield Medical Center - Weston — Weston, Wisconsin, United States
  • Marshfield Clinic - Wisconsin Rapids Center — Wisconsin Rapids, Wisconsin, United States
  • Memorial Hospital of Laramie County — Cheyenne, Wyoming, United States
  • Billings Clinic-Cody — Cody, Wyoming, United States
  • Welch Cancer Center — Sheridan, Wyoming, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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