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MRS Measurement of Glutamate and GABA Metabolism in Brain

Sponsor: National Institute of Mental Health (NIMH) • ClinicalTrials.gov ID: NCT00109174

Registry updated: 2026-10-13

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Description

This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of \[13\]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA).

Interventions

3T and 7T device (Device)
3T and 7T device

Eligibility criteria

* INCLUSION CRITERIA: * 18-65 years of age * Able to give written informed consent * Healthy based on medical history and physical exam * Enrolled in Protocol 01-M-0254 or Protocol 17-M-0181 EXCLUSION CRITERIA: * Any current Axis 1 diagnosis * Clinically significant laboratory abnormalities * Positive HIV test * Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan. * History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury * Prescription psychotropic medication, drug free less than 8 weeks (anticholinergics, benzodiazepine, fluoxetine, antipsychotics, and anticonvulsants) * Serious medical illness as determined from H\&P or laboratory testing including Diabetes * Inability to lie flat on camera bed for about two and a half hours * Pregnant or breastfeeding * Current substance use disorder based on DSM-5 * NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.

Conditions

Normal Physiology

Locations

National Institutes of Health Clinical Center — Bethesda, Maryland, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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